Aim To develop pluronic F127 （PF127） based formulations of penciclovir （PCV） aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of ...Aim To develop pluronic F127 （PF127） based formulations of penciclovir （PCV） aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of HPMC K4M or carbopol 934P and pluronic F127. Optimized formulations were examined through measuring gelation temperature, rheology speciality, drug release behavior, pharmacokinetics and ocular irritation. Results The gelation temperature was reduced by adding HPMC K4M or carbopol 934P, and the viscosity was enhanced slightly. Either HPMC K4M or carbopol 934P delayed the release of PCV from in situ gel. PCV was released by non-Fickian diffusion. The study of ocular irritation for different PCV formulations did not show any irritation or damage for the cornea. PCV bioavailability from combination of carbopol 934P and pluronic F127 gels was higher than that obtained from any other gels. Conclusion Pluronic F127 formulations of PCV can be used as liquid for administration by instilling into the eye. Facilitated by the appropriate eye temperature, the formulations were transformed to gel phase. On the basis of in vitro and in vivo results, PCV formulations containing HPMC K4M or carbopol 934P and low concentration of pluronic F127 （12%） showed potential for use as a drug delivery system with improved ocular bioavailability.展开更多
The mechanism of gas discharge in refrigeration temperature range is still not clear. N2, CF4, 20% CF4＋N2 and 50%CF4＋50%N2 binary gas mixtures were tested under the conditions of –153–25 ℃ and 50–2000 Pa. The ex...The mechanism of gas discharge in refrigeration temperature range is still not clear. N2, CF4, 20% CF4＋N2 and 50%CF4＋50%N2 binary gas mixtures were tested under the conditions of –153–25 ℃ and 50–2000 Pa. The experimental results show that the minimum of Paschen curves of all test samples shifts to low pressure, from 500 Pa to 200 Pa. The value of Paschen curve minimum of N2 shows remarkable fluctuation. This fluctuation is explained by molecule agglomeration and electronic mean energy. The fluctuation decreases with the increasing mixing ratio of CF4. What’s more, the value of Paschen curve minimum of CF4 decreases with temperature. This phenomenon is ascribed to attach-radiation and secondary process.展开更多
In order to get the dynamic mechanical properties of deep rock mass suffered both high temperature and high pressure,impact loading experiments on granite subjected to temperature and axial pressure were carried out. ...In order to get the dynamic mechanical properties of deep rock mass suffered both high temperature and high pressure,impact loading experiments on granite subjected to temperature and axial pressure were carried out. Furthermore, the internalstructure characteristics of granite under different temperatures were observed by scanning electron microscopy (SEM). The results show that the longitudinal wave velocity assumes a downward trend which shows a rapid drop before falling slowly as the temperature increases. The uniaxial compressive strength of the specimen decreases significantly at temperatures of 25?100 °C compared to that at temperatures of 100?300 °C. The peak strain rises rapidly before the dividing point of 100 °C, but increases slowly after the dividing point. The internal structure of the rock changes substantially as the temperature increases, such as the extension and transfixion of primary and newborn cracks. In addition, the thermal damage under axial pressure is greater than that described by the longitudinal wave velocity and the phenomenon shows obviously when the temperature increases.展开更多
A number of recent studies have examined trends in extreme temperature indices using a linear regression model based on ordinary least-squares. In this study, quantile regression was, for the first time, applied to ex...A number of recent studies have examined trends in extreme temperature indices using a linear regression model based on ordinary least-squares. In this study, quantile regression was, for the first time, applied to examine the trends not only in the mean but also in all parts of the distribution of several extreme temperature indices in China for the period 1960–2008. For China as a whole, the slopes in almost all the quantiles of the distribution showed a notable increase in the numbers of warm days and warm nights, and a significant decrease in the number of cool nights. These changes became much faster as the quantile increased. However, although the number of cool days exhibited a significant decrease in the mean trend estimated by classical linear regression, there was no obvious trend in the upper and lower quantiles. This finding suggests that examining the trends in different parts of the distribution of the time-series is of great importance. The spatial distribution of the trend in the 90 th quantile indicated that there was a pronounced increase in the numbers of warm days and warm nights, and a decrease in the number of cool nights for most of China, but especially in the northern and western parts of China, while there was no significant change for the number of cool days at almost all the stations.展开更多
In this study,the reversal of monthly East Asian winter air temperature(EAWT) in 2020/21 and its predictability were investigated.The reversal of monthly EAWT in 2020/21 was characterized by colder temperatures in ear...In this study,the reversal of monthly East Asian winter air temperature(EAWT) in 2020/21 and its predictability were investigated.The reversal of monthly EAWT in 2020/21 was characterized by colder temperatures in early winter(December 2020 to mid-January 2021) and warmer temperatures in late winter(mid-January to February 2021).Results show that the reversal in the intensity of the Siberian high(SH) also occurred between early and late winter in 2020/21.In early winter,as the Barents-Laptev sea ice in the previous September(i.e., in2020) reached a minimum for the period 1981-2020,the SH was strengthaned via a reduction of the meridional gradient between the Arctic and East Asia.In late winter,as a sudden stratospheric warming occurred on 5 January 2021,the stratospheric polar vortex weakened,with the weakest center shifting to North America in January.Subsequently,the negative Arctic Oscillation-like structure shifted towards North America in the middle and lower troposphere,which weakened the SH in late winter.Furthermore,the predictability of the reversal in EAWT in 2020/21 was validated based on monthly and daily predictions from NCEP-CFSv2(National Centers for Environment Prediction-Climate Forecast System,version 2).The results showed that the model was unable to reproduce the monthly reversal of EAWT.However,it was able to forecast the reversal date(18 January 2021)of EAWT at lead times of 1-20 days on the daily scale.展开更多
As an experimental technique, it’s desired that the temperature in specimen is uniform in high temperature split Hopkinson pressure bar (SHPB) experiments. However, the temperature in specimen decreases and the tempe...As an experimental technique, it’s desired that the temperature in specimen is uniform in high temperature split Hopkinson pressure bar (SHPB) experiments. However, the temperature in specimen decreases and the temperature of bars increases when specimen starts to contact with bars, which induces the nonuniform temperature distribution in specimen, and may result in inac-curacy of experimental results. In this paper, the temperature distributions of specimen and bars in high temperature SHPB experiments were investigated while the specimen was heated alone. Firstly, the temperature history of specimen was measured at different initial temperatures by ex-periments, then simulation was carried out. Simulation results were consistent with experimental results by adjusting the thermal contact coefficient between specimen and bars. By this way, the thermal contact coefficient and simulation results were validated, and the proper cold contact times of specimen and bars in high temperature SHPB experiments were discussed. Finally, the results were compared with those in references.展开更多
Considering the contribution of both the outer and inner horizons, the Hamilton-Jacobi method is applied to a Kerr-Newman black hole and a negative temperature of the inner horizon is obtained. Under the negative temp...Considering the contribution of both the outer and inner horizons, the Hamilton-Jacobi method is applied to a Kerr-Newman black hole and a negative temperature of the inner horizon is obtained. Under the negative temperature inside the black hole, the thermodynamics of the two horizons is studied, and the new Bekenstein-Smarr formula is given. The entropies of the inner and outer horizons are all positive. The new entropy expression of the black hole satisfies the Nernst Theorem and can be regarded as the Planck absolute entropy.展开更多
The South China Sea(SCS) is one of the most active areas of internal waves.We undertook a program of physical oceanography in the northern South China Sea from June to July of 2009,and conducted a 1-day observation fr...The South China Sea(SCS) is one of the most active areas of internal waves.We undertook a program of physical oceanography in the northern South China Sea from June to July of 2009,and conducted a 1-day observation from 15:40 of June 24 to 16:40 of June 25 using a chain of instruments,including temperature sensors,pressure sensors and temperature-pressure meters at a site(117.5°E,21°N) northeast of the Dongsha Islands.We measured fluctuating tidal and subtidal properties with the thermistor-chain and a ship-mounted Acoustic Doppler Current Profiler,and observed a large-amplitude nonlinear internal wave passing the site followed by a number of small ones.To further investigate this phenomenon,we collected the tidal constituents from the TPXO7.1 dataset to evaluate the tidal characteristics at and around the recording site,from which we knew that the amplitude of the nonlinear internal wave was about 120 m and the period about 20 min.The horizontal and vertical velocities induced by the soliton were approximately 2 m/s and 0.5 m/s,respectively.This soliton occurred 2-3 days after a spring tide.展开更多
Effects of extratropical solar penetration on the North Atlantic Ocean circulation and climate are investigated using a coupled ocean-atmosphere model.In this model,solar penetration generates basinwide cooling and wa...Effects of extratropical solar penetration on the North Atlantic Ocean circulation and climate are investigated using a coupled ocean-atmosphere model.In this model,solar penetration generates basinwide cooling and warming in summer and winter,respectively.Associated with SST changes,annual mean surface wind stress is intensified in both the subtropical and subpolar North Atlantic,which leads to acceleration of both subtropical and subpolar gyres.Owing to warming in the subtropics and significant saltiness in the subpolar region,potential density decreases(increases) in the subtropical(subpolar)North Atlantic.The north-south meridional density gradient is thereby enlarged,accelerating the Atlantic meridional overturning circulation(AMOC).In addition,solar penetration reduces stratification in the upper ocean and favors stronger vertical convection,which also contributes to acceleration of the AMOC.展开更多
Internal solitary waves （ISWs） are frequently observed in the area between Dongsha Island （DI） and Taiwan Island. However, there have been few in-situ observations southwest of DI. To improve our knowledge of ISWs...Internal solitary waves （ISWs） are frequently observed in the area between Dongsha Island （DI） and Taiwan Island. However, there have been few in-situ observations southwest of DI. To improve our knowledge of ISWs in this area, we observed the ISWs over the continental shelf （115.4°E, 20.3°N） from Aug. 29 to Oct. 10, 2011 with temperature sensors and an acoustic Doppler current profiler （ADCP）. The observations showed that the a fully developed ISW produced a current whose maximum westward velocity was 0.92 rrds and maximum northward velocity was 0.47 m/s. During the 41-day observation period the ISWs appeared for three periods with about 7-day gaps between each period. During each day, two types of ISWs were observed. The first type of wave arrived regularly diurnally at the same time each day, with a similar pattern to that of the type-a wave identified by Ramp et al. （2004）. The second type arrived about 12 h after the first type and was delayed about 1 hour each day; this wave type was related to the type-b wave. Thus, our observations confirmed that both type-a and type-b waves can reach the area southwest of the DI. Moreover, the waves observed by the mooring propagated toward the directions of 270°-315° clockwise from true north, indicating obvious refraction from uneven topography around DI.展开更多
In this work, we constrain the spectral index nt of the primordial gravitational wave power spectrum in a universe with sterile neutrinos by using the Planck temperature data, the WMAP 9-year polarization data, the ba...In this work, we constrain the spectral index nt of the primordial gravitational wave power spectrum in a universe with sterile neutrinos by using the Planck temperature data, the WMAP 9-year polarization data, the baryon acoustic oscillation data, and the BICEP2 data. We call this model the ACDM＋r＋vs＋nt model. The additional massive sterile neutrino species can significantly relieve the tension between the Planck and BICEP2 data, and thus can reduce the possible effects of this tension on the fit results of nt. To constrain the parameters of sterile neutrino, we also utilize the Hubble constant direct measurement data, the Planck Sunyaev-Zeldovich cluster counts data, the Planck CMB lensing data, and the cosmic shear data. We find that due to the fact that the BICEP2 data are most sensitive to the multipole （ - 150 corresponding to k - 0.01 Mpc^-1, there exists a strong anticorrelation between nt and r0.0o2 in the BICEP2 data, and this further results in a strongly blue-tilt spectrum. However, a slightly red-tilt tensor power spectrum is also allowed by the BICEP2 data in the region with larger value of r0.00z. By using the full data sets, we obtain mvisterile ^eff = 0.48 -0.13^＋0.11 eV, Near = 3.73 -0.37^＋0.34, and nt = 0.96 -0.63^ ＋0.48 for the ACDM＋r＋vs＋nt model.展开更多
文摘Aim To develop pluronic F127 （PF127） based formulations of penciclovir （PCV） aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of HPMC K4M or carbopol 934P and pluronic F127. Optimized formulations were examined through measuring gelation temperature, rheology speciality, drug release behavior, pharmacokinetics and ocular irritation. Results The gelation temperature was reduced by adding HPMC K4M or carbopol 934P, and the viscosity was enhanced slightly. Either HPMC K4M or carbopol 934P delayed the release of PCV from in situ gel. PCV was released by non-Fickian diffusion. The study of ocular irritation for different PCV formulations did not show any irritation or damage for the cornea. PCV bioavailability from combination of carbopol 934P and pluronic F127 gels was higher than that obtained from any other gels. Conclusion Pluronic F127 formulations of PCV can be used as liquid for administration by instilling into the eye. Facilitated by the appropriate eye temperature, the formulations were transformed to gel phase. On the basis of in vitro and in vivo results, PCV formulations containing HPMC K4M or carbopol 934P and low concentration of pluronic F127 （12%） showed potential for use as a drug delivery system with improved ocular bioavailability.
基金Project(51277063) supported by the National Natural Science Foundation of ChinaProject(51407013) supported in part by the National Natural Science Foundation of China
文摘The mechanism of gas discharge in refrigeration temperature range is still not clear. N2, CF4, 20% CF4＋N2 and 50%CF4＋50%N2 binary gas mixtures were tested under the conditions of –153–25 ℃ and 50–2000 Pa. The experimental results show that the minimum of Paschen curves of all test samples shifts to low pressure, from 500 Pa to 200 Pa. The value of Paschen curve minimum of N2 shows remarkable fluctuation. This fluctuation is explained by molecule agglomeration and electronic mean energy. The fluctuation decreases with the increasing mixing ratio of CF4. What’s more, the value of Paschen curve minimum of CF4 decreases with temperature. This phenomenon is ascribed to attach-radiation and secondary process.
基金Project(51304241)supported by the Youth Project of National Natural Science Foundation of ChinaProject(2014M552164)supported by Chinese Postdoctoral Science FoundationProject(20130162120015)supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China
文摘In order to get the dynamic mechanical properties of deep rock mass suffered both high temperature and high pressure,impact loading experiments on granite subjected to temperature and axial pressure were carried out. Furthermore, the internalstructure characteristics of granite under different temperatures were observed by scanning electron microscopy (SEM). The results show that the longitudinal wave velocity assumes a downward trend which shows a rapid drop before falling slowly as the temperature increases. The uniaxial compressive strength of the specimen decreases significantly at temperatures of 25?100 °C compared to that at temperatures of 100?300 °C. The peak strain rises rapidly before the dividing point of 100 °C, but increases slowly after the dividing point. The internal structure of the rock changes substantially as the temperature increases, such as the extension and transfixion of primary and newborn cracks. In addition, the thermal damage under axial pressure is greater than that described by the longitudinal wave velocity and the phenomenon shows obviously when the temperature increases.
基金sponsored by the National Basic Research Program of China (973 Program, Grant No. 2012CB956203)the Knowledge Innovation Project of the Chinese Academy of Sciences (Grant No. KZCX2-EW-202)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA05090100)
文摘A number of recent studies have examined trends in extreme temperature indices using a linear regression model based on ordinary least-squares. In this study, quantile regression was, for the first time, applied to examine the trends not only in the mean but also in all parts of the distribution of several extreme temperature indices in China for the period 1960–2008. For China as a whole, the slopes in almost all the quantiles of the distribution showed a notable increase in the numbers of warm days and warm nights, and a significant decrease in the number of cool nights. These changes became much faster as the quantile increased. However, although the number of cool days exhibited a significant decrease in the mean trend estimated by classical linear regression, there was no obvious trend in the upper and lower quantiles. This finding suggests that examining the trends in different parts of the distribution of the time-series is of great importance. The spatial distribution of the trend in the 90 th quantile indicated that there was a pronounced increase in the numbers of warm days and warm nights, and a decrease in the number of cool nights for most of China, but especially in the northern and western parts of China, while there was no significant change for the number of cool days at almost all the stations.
基金jointly supported by the National Natural Science Foundation of China [grant numbers 42088101 and 41730964]the Innovation Group Project of the Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) [grant number 311021001]。
文摘In this study,the reversal of monthly East Asian winter air temperature(EAWT) in 2020/21 and its predictability were investigated.The reversal of monthly EAWT in 2020/21 was characterized by colder temperatures in early winter(December 2020 to mid-January 2021) and warmer temperatures in late winter(mid-January to February 2021).Results show that the reversal in the intensity of the Siberian high(SH) also occurred between early and late winter in 2020/21.In early winter,as the Barents-Laptev sea ice in the previous September(i.e., in2020) reached a minimum for the period 1981-2020,the SH was strengthaned via a reduction of the meridional gradient between the Arctic and East Asia.In late winter,as a sudden stratospheric warming occurred on 5 January 2021,the stratospheric polar vortex weakened,with the weakest center shifting to North America in January.Subsequently,the negative Arctic Oscillation-like structure shifted towards North America in the middle and lower troposphere,which weakened the SH in late winter.Furthermore,the predictability of the reversal in EAWT in 2020/21 was validated based on monthly and daily predictions from NCEP-CFSv2(National Centers for Environment Prediction-Climate Forecast System,version 2).The results showed that the model was unable to reproduce the monthly reversal of EAWT.However,it was able to forecast the reversal date(18 January 2021)of EAWT at lead times of 1-20 days on the daily scale.
文摘As an experimental technique, it’s desired that the temperature in specimen is uniform in high temperature split Hopkinson pressure bar (SHPB) experiments. However, the temperature in specimen decreases and the temperature of bars increases when specimen starts to contact with bars, which induces the nonuniform temperature distribution in specimen, and may result in inac-curacy of experimental results. In this paper, the temperature distributions of specimen and bars in high temperature SHPB experiments were investigated while the specimen was heated alone. Firstly, the temperature history of specimen was measured at different initial temperatures by ex-periments, then simulation was carried out. Simulation results were consistent with experimental results by adjusting the thermal contact coefficient between specimen and bars. By this way, the thermal contact coefficient and simulation results were validated, and the proper cold contact times of specimen and bars in high temperature SHPB experiments were discussed. Finally, the results were compared with those in references.
基金Supported by National Natural Science Foundation of China under Grant Nos.10773002,10875012the National Basic Research Program of China under Grant No.2003CB716302
文摘Considering the contribution of both the outer and inner horizons, the Hamilton-Jacobi method is applied to a Kerr-Newman black hole and a negative temperature of the inner horizon is obtained. Under the negative temperature inside the black hole, the thermodynamics of the two horizons is studied, and the new Bekenstein-Smarr formula is given. The entropies of the inner and outer horizons are all positive. The new entropy expression of the black hole satisfies the Nernst Theorem and can be regarded as the Planck absolute entropy.
基金Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (Nos.KZCX1-YW-12,KZCX2-YW-201)the National High Technology Research and Development Program of China (863 Program) (No.2008AA09A402)
文摘The South China Sea(SCS) is one of the most active areas of internal waves.We undertook a program of physical oceanography in the northern South China Sea from June to July of 2009,and conducted a 1-day observation from 15:40 of June 24 to 16:40 of June 25 using a chain of instruments,including temperature sensors,pressure sensors and temperature-pressure meters at a site(117.5°E,21°N) northeast of the Dongsha Islands.We measured fluctuating tidal and subtidal properties with the thermistor-chain and a ship-mounted Acoustic Doppler Current Profiler,and observed a large-amplitude nonlinear internal wave passing the site followed by a number of small ones.To further investigate this phenomenon,we collected the tidal constituents from the TPXO7.1 dataset to evaluate the tidal characteristics at and around the recording site,from which we knew that the amplitude of the nonlinear internal wave was about 120 m and the period about 20 min.The horizontal and vertical velocities induced by the soliton were approximately 2 m/s and 0.5 m/s,respectively.This soliton occurred 2-3 days after a spring tide.
基金Supported by the Key Project of National Natural Science Foundation of China(No.41130859)the Innovation Team Project(No.40921004)
文摘Effects of extratropical solar penetration on the North Atlantic Ocean circulation and climate are investigated using a coupled ocean-atmosphere model.In this model,solar penetration generates basinwide cooling and warming in summer and winter,respectively.Associated with SST changes,annual mean surface wind stress is intensified in both the subtropical and subpolar North Atlantic,which leads to acceleration of both subtropical and subpolar gyres.Owing to warming in the subtropics and significant saltiness in the subpolar region,potential density decreases(increases) in the subtropical(subpolar)North Atlantic.The north-south meridional density gradient is thereby enlarged,accelerating the Atlantic meridional overturning circulation(AMOC).In addition,solar penetration reduces stratification in the upper ocean and favors stronger vertical convection,which also contributes to acceleration of the AMOC.
基金Supported by the National Natural Science Foundation of China(Nos.41030855,U1133001,41376027)National High Technology Research and Development Program of China(863 Program)(No.2013AA09A502)
文摘Internal solitary waves （ISWs） are frequently observed in the area between Dongsha Island （DI） and Taiwan Island. However, there have been few in-situ observations southwest of DI. To improve our knowledge of ISWs in this area, we observed the ISWs over the continental shelf （115.4°E, 20.3°N） from Aug. 29 to Oct. 10, 2011 with temperature sensors and an acoustic Doppler current profiler （ADCP）. The observations showed that the a fully developed ISW produced a current whose maximum westward velocity was 0.92 rrds and maximum northward velocity was 0.47 m/s. During the 41-day observation period the ISWs appeared for three periods with about 7-day gaps between each period. During each day, two types of ISWs were observed. The first type of wave arrived regularly diurnally at the same time each day, with a similar pattern to that of the type-a wave identified by Ramp et al. （2004）. The second type arrived about 12 h after the first type and was delayed about 1 hour each day; this wave type was related to the type-b wave. Thus, our observations confirmed that both type-a and type-b waves can reach the area southwest of the DI. Moreover, the waves observed by the mooring propagated toward the directions of 270°-315° clockwise from true north, indicating obvious refraction from uneven topography around DI.
基金supported by the National Natural Science Foundation of China (Grant No. 11175042)the National Ministry of Education of China (Grant No. N120505003)
文摘In this work, we constrain the spectral index nt of the primordial gravitational wave power spectrum in a universe with sterile neutrinos by using the Planck temperature data, the WMAP 9-year polarization data, the baryon acoustic oscillation data, and the BICEP2 data. We call this model the ACDM＋r＋vs＋nt model. The additional massive sterile neutrino species can significantly relieve the tension between the Planck and BICEP2 data, and thus can reduce the possible effects of this tension on the fit results of nt. To constrain the parameters of sterile neutrino, we also utilize the Hubble constant direct measurement data, the Planck Sunyaev-Zeldovich cluster counts data, the Planck CMB lensing data, and the cosmic shear data. We find that due to the fact that the BICEP2 data are most sensitive to the multipole （ - 150 corresponding to k - 0.01 Mpc^-1, there exists a strong anticorrelation between nt and r0.0o2 in the BICEP2 data, and this further results in a strongly blue-tilt spectrum. However, a slightly red-tilt tensor power spectrum is also allowed by the BICEP2 data in the region with larger value of r0.00z. By using the full data sets, we obtain mvisterile ^eff = 0.48 -0.13^＋0.11 eV, Near = 3.73 -0.37^＋0.34, and nt = 0.96 -0.63^ ＋0.48 for the ACDM＋r＋vs＋nt model.
