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甘草酸二铵联用红花注射液对大鼠溃疡性结肠炎炎症的影响 被引量:2
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作者 原皓 王鹤鸣 韩雪 《世界华人消化杂志》 CAS 北大核心 2013年第31期3338-3343,共6页
目的:建立2,4,6-三硝基苯磺酸(2,4,6-trinitrobenzene sulfonic acid,TNBS)诱导的溃疡性结肠炎(ulcerative colitis,UC)大鼠模型,对比甘草酸二铵(diammonium glycyrrhizinate,DG)联合红花注射液(safflower solution,SS)与单用DG的疗效... 目的:建立2,4,6-三硝基苯磺酸(2,4,6-trinitrobenzene sulfonic acid,TNBS)诱导的溃疡性结肠炎(ulcerative colitis,UC)大鼠模型,对比甘草酸二铵(diammonium glycyrrhizinate,DG)联合红花注射液(safflower solution,SS)与单用DG的疗效及对促炎因子白介素-8(interleukin-8,IL-8)表达的影响,从而探讨抗炎药DG联合改善微循环的SS治疗UC的价值.方法:40只健康SD大鼠随机分为正常对照组、实验组(DG+SS)、DG组和模型组,每组10只.实验组、模型组、DG组大鼠用2,4,6-三硝基苯磺酸(TNBS)灌肠复制溃疡性结肠炎模型,实验组每天给予40 mg/kg DG加400 mg/kg SS腹腔注射干预治疗,DG组每天给予40 mg/kg DG治疗,正常对照组及模型对照组给予等容积生理盐水腹腔注射.10 d后观察大鼠疾病活动指数(disease activity index,DAI)及结肠组织学变化,并用免疫组织化学方法检测大鼠结肠IL-8的表达.结果:正常对照组、实验组(DG+SS)、模型组和DG组的DAI评分分别为1.4±0.3、2.4±0.2、3.8±0.4和7.6±0.9;组织学损伤评分分别为1.5±0.4、2.4±0.4、3.7±0.6和6.3±1.1;IL-8阳性率分别为15.7%±3.7%、20.8%±4.7%、34.7%±4.9%和56.4%±6.9%.与模型组相比,实验组与DG组的DAI和组织学表现显著改善,IL-8的表达显著降低(P<0.01),而实验组又比DG组效果好(P<0.05),经one-way ANOVA及SNK-q检验,差异有统计学意义.结论:DG联合SS对大鼠UC的疗效及对促炎因子IL-8表达的抑制作用均好于DG单独的作用,提示抗炎联合改善微循环是一种较单用抗炎药物治疗UC的更有效的方法,更有效地抑制IL-8的生成及改善微循环是其可能的机制之一. 展开更多
关键词 甘草酸二铵 红花注射液 溃疡结肠炎炎症 治疗
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常见小肠炎症性溃疡性疾病的X线研究
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作者 张谦 李世忠 《中原医刊》 2000年第3期11-12,共2页
关键词 小肠炎症溃疡疾病 X线诊断 症状
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小肠炎症溃疡性疾病影像诊断及临床分析(附18例报告)
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作者 刘培智 徐进 《吉林医学信息》 1999年第8期16-16,共1页
关键词 小肠炎症溃疡疾病 影像诊断 临床分析
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辨证分型治疗溃疡性结肠炎肠黏膜组织炎症随机平行对照研究 被引量:1
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作者 郑剑波 《实用中医内科杂志》 2015年第2期117-119,共3页
[目的]观察辨证分型治疗溃疡性结肠炎肠黏膜组织炎症疗效。[方法]使用随机平行对照方法,将90例门诊及住院患者按病志号抽签法简单随机分为两组。对照组45例柳氮磺吡啶,2g/次,3次/d。治疗组45例辨证分型:脾胃虚寒(党参24g,茯苓20g,白术1... [目的]观察辨证分型治疗溃疡性结肠炎肠黏膜组织炎症疗效。[方法]使用随机平行对照方法,将90例门诊及住院患者按病志号抽签法简单随机分为两组。对照组45例柳氮磺吡啶,2g/次,3次/d。治疗组45例辨证分型:脾胃虚寒(党参24g,茯苓20g,白术14g,山药、川楝子、白芍、陈皮、补骨脂、扁豆各12g,山楂10g,肉桂9g,吴茱萸、五味子、甘草炙各6g,鸡内金5g);湿热蕴结(葛根、金银花各24g,薏苡仁30g,白芍、陈皮、连翘各14g,木香12g,厚朴10g,生甘草6g);肝郁脾虚(党参24g,白芍、白术、当归各14g,柴胡、乌梅、陈皮、防风各12g,干姜10g,甘草、吴茱萸各6g);脾肾阳虚(党参20g,当归14g,肉豆蔻、吴茱萸、诃子、白术、白芍、木香各12g,肉桂9g,补骨脂12g,甘草、五味子各6g);均1剂/d,水煎200m L,早晚口服。连续治疗3d为1疗程。观测临床症状、腹痛、腹泻、肠黏膜、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组痊愈43例,有效2例,无效0例,总有效率100.00%。对照组痊愈28例,有效9例,无效8例,总有效率82.22%。治疗组疗效优于对照组(P<0.05)。[结论]辨证分型治疗溃疡性结肠炎肠黏膜组织炎症效果显著,无严重不良反应,值得推广。 展开更多
关键词 溃疡结肠炎肠黏膜组织炎症 辨证分型 脾胃虚寒 肝郁脾虚 湿热蕴结 脾肾阳虚 腹痛 腹泻 肠黏膜 中医药疗法 随机平行对照研究
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自拟肠康煎治疗阳虚湿热型溃疡性结肠炎65例
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作者 刘国军 《国医论坛》 2009年第6期18-,共1页
溃疡性结肠炎(UC)是结肠慢性非特异性溃疡性炎症,原因未明,多数学者认为可能是自身免疫病,感染与精神因素可诱发本病,以腹痛、腹泻、黏液脓血便等临床表现为特征,常反复发作,缠绵难愈.目前西医治疗多选用水杨酸类药物、类固醇激素以及... 溃疡性结肠炎(UC)是结肠慢性非特异性溃疡性炎症,原因未明,多数学者认为可能是自身免疫病,感染与精神因素可诱发本病,以腹痛、腹泻、黏液脓血便等临床表现为特征,常反复发作,缠绵难愈.目前西医治疗多选用水杨酸类药物、类固醇激素以及免疫抑制剂等,疗效不尽人意.近年来笔者运用自拟方肠康煎口服、灌肠治疗UC(阳虚湿热型)65例,并设对照组60例进行对比观察,取得了满意疗效,现报道如下. 展开更多
关键词 西医治疗 阳虚 湿热型 溃疡结肠炎 水杨酸类药物 非特异 自身免疫病 现报道如下 免疫抑制剂 类固醇激素 溃疡性炎症 临床表现 疗效 精神因素 灌肠治疗 反复发作 对比观察 自拟方 脓血便 对照组
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MES、UCEIS联合DUBLIN评分在溃疡性结肠炎疾病管理中的应用 被引量:1
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作者 顾林 赵睿 +4 位作者 马振增 邓敏 郑海伦 燕善军 秦丹 《皖南医学院学报》 CAS 2023年第4期364-367,共4页
目的:评价溃疡性结肠炎(UC)内镜评分系统在疾病管理中的临床应用价值。方法:回顾性分析2016年11月~2022年11月住院的203例UC患者,另随机选取206名同期健康体检者。统计两组基线特征,分析内镜评分与临床参数之间的关系。结果:UC患者的炎... 目的:评价溃疡性结肠炎(UC)内镜评分系统在疾病管理中的临床应用价值。方法:回顾性分析2016年11月~2022年11月住院的203例UC患者,另随机选取206名同期健康体检者。统计两组基线特征,分析内镜评分与临床参数之间的关系。结果:UC患者的炎症指标较健康体检者升高,差异有统计学意义。评估疾病严重程度方面,Mayo内镜评分(MES)和溃疡性结肠炎内镜严重程度指数(UCEIS)更具有优势(H=187.491、156.567,P<0.001)。UCEIS和溃疡性结肠炎管腔炎症负荷严重程度评分(DUBLIN)在评估UC患者的疾病炎症负荷方面优于MES,UCEIS预测治疗反应和升级治疗方面效能较高。结论:DUBLIN评分方法简单,操作便捷,更适合在日常临床实践中应用;UCEIS可以更好地预测是否需升级治疗,适合为UC患者制定个性化的治疗方案。 展开更多
关键词 溃疡结肠炎 Mayo内镜评分 溃疡结肠炎内镜严重程度指数 溃疡结肠炎管腔炎症负荷严重程度评分
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肉羊常见病的诊疗技术(二)
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作者 刘敏 《农业知识(瓜果菜)》 2008年第1期10-11,共2页
4.蓝舌病。是由蓝舌病毒引起的一种传染病,绵羊易感性最大,山羊也能患此病。该病的特征是发热,白细胞减少,病羊口腔、鼻腔和胃肠黏膜出现溃疡性炎症。
关键词 蓝舌病毒 舌病 溃疡性炎症 多头蚴病 伪结核病 捻转血矛线虫病 丙硫咪唑 口腔黏膜充血 幼羊 蹄冠
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反刍动物蓝舌病的诊断及防控措施 被引量:1
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作者 林淑娟 《中国动物保健》 2017年第3期51-52,共2页
蓝舌病是由蓝舌病病毒(Blue tongue vires,BTV)引起的反刍动物的一种急热性传染病。临床特征主要表现为病畜口鼻、胃肠道黏膜出现溃疡性炎症变化。该病可导致胎儿畸形、幼畜发育不良甚至死亡,给反刍养殖造成了巨大的经济损失。基于此... 蓝舌病是由蓝舌病病毒(Blue tongue vires,BTV)引起的反刍动物的一种急热性传染病。临床特征主要表现为病畜口鼻、胃肠道黏膜出现溃疡性炎症变化。该病可导致胎儿畸形、幼畜发育不良甚至死亡,给反刍养殖造成了巨大的经济损失。基于此,笔者结合实践经验,阐述了反刍动物蓝舌病的诊断和防控措施。 展开更多
关键词 舌病 蓝舌病病毒 溃疡性炎症 传染病 胃肠道黏膜 胎儿畸形 库蠓 tongue 发育不良 呼肠孤病毒科
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羔羊痢疾的症状及防治措施
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作者 李太春 《中兽医学杂志》 2016年第5期60-60,共1页
羔羊痢疾是由B型魏氏梭菌引起初生羔羊的一种急性毒血症,其特征为剧烈腹泻和小肠发生出血性、溃疡性炎症。死亡率很高,对养羊业的危害很大。1流行病学本病主要危害1周龄以内的羔羊,其中2-3日龄羔羊发病最多,随着日龄的增长,易感性逐渐降... 羔羊痢疾是由B型魏氏梭菌引起初生羔羊的一种急性毒血症,其特征为剧烈腹泻和小肠发生出血性、溃疡性炎症。死亡率很高,对养羊业的危害很大。1流行病学本病主要危害1周龄以内的羔羊,其中2-3日龄羔羊发病最多,随着日龄的增长,易感性逐渐降低,7日龄以上的羔羊很少发病。?羔羊及带菌母羊是重要的传染源,其传播途径是病菌从污染的饲料、饮水等经消化道感染。 展开更多
关键词 羔羊痢疾 羔羊发病 初生羔羊 溃疡性炎症 消化道感染 剧烈腹泻 魏氏梭菌 毒血症 病主 菌母
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家兔常见皮肤病的防治
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作者 宋富华 《兽医导刊》 2015年第9期70-72,共3页
(一)脚皮炎家兔脚底部出现破皮、损伤、炎症、化脓性感染等症状的一种疾病。1.病因。主要是由于家兔长期呆于兔笼内,脚底部皮肤被笼底的粗糙不平或尖锐异物刺伤、刮伤,继发细菌感染后发生化脓性或溃疡性炎症。还有的种兔因体型大,长... (一)脚皮炎家兔脚底部出现破皮、损伤、炎症、化脓性感染等症状的一种疾病。1.病因。主要是由于家兔长期呆于兔笼内,脚底部皮肤被笼底的粗糙不平或尖锐异物刺伤、刮伤,继发细菌感染后发生化脓性或溃疡性炎症。还有的种兔因体型大,长期在无竹笼底板的铁丝上站立,因铁丝较细,使脚底单位面积承载重量过大,长期这样引起兔脚底皮肤出现压迫性炎症。2.症状。脚趾部脚皮炎(图1)病兔表现出患肢疼痛,不愿着地, 展开更多
关键词 溃疡性炎症 承载重量 常见皮肤病 继发细菌感染 种兔 趾部 压迫 单位面积 化脓感染 综合防制措施
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夏秋绵羊蓝舌病的防治
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作者 郑延平 《现代农业科学》 1994年第8期31-31,共1页
蓝舌病是反刍动物的一种病毒性传染病,绵羊最易感染发生,以口腔、鼻腔和胃肠道粘膜的溃疡性炎症为主要特征。此病主要是由于蚊虫的传播而发生的。所以本病主要发生在夏秋季节的6~10月间。 症状 本病潜伏期一般为6至9天,常见的有急性型... 蓝舌病是反刍动物的一种病毒性传染病,绵羊最易感染发生,以口腔、鼻腔和胃肠道粘膜的溃疡性炎症为主要特征。此病主要是由于蚊虫的传播而发生的。所以本病主要发生在夏秋季节的6~10月间。 症状 本病潜伏期一般为6至9天,常见的有急性型和亚急性型。慢性型的则很少有。 展开更多
关键词 蓝舌病 绵羊 溃疡性炎症 病毒传染病 口腔 主要特征 体外寄生虫 肠道粘膜 反刍动物
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Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis 被引量:9
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作者 Hiroyuki Hanai 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第47期7568-7577,共10页
Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that afflict millions of individuals throug... Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that afflict millions of individuals throughout the world with symptoms which impair function and quality of life. The etiology of IBD is inadequately understood and therefore, drug therapy has been empirical instead of being based on sound understanding of IBD pathogenesis. This is a major factor for poor drug efficacy and drug related side effects that often add to the disease complexity. The development of biologicals notably infliximab to intercept tumor necrosis factor (TNF)-α reflects some progress, albeit major concern about their side effects and lack of long-term safety and efficacy profiles. However, IBD seems to be perpetuated by inflammatory cytokines like TNF-α, interleukin (IL)-Iβ, IL-6 and IL-8 for which activated peripheral granulocytes and monocytes/macrophages (GH) are major sources. Further, in IBD, peripheral GHs are elevated with activation behavior, increased survival time and are found in vast numbers within the inflamed intestinal mucosa; they are suspected to be major factors in the immunopathogenesis of IBD. Hence, peripheral blood GMs should be appropriate targets of therapy. The Adacolumn is a medical device developed for selective depletion of GH by receptor-mediated adsorption (GHA). Clinical data show GMA, in patients with steroid dependent or steroid refractory UC, is associated with up to 85% efficacy and tapering or discontinuation of steroids, while in steroid nai've patients (the best responders), GHA spares patients from exposure to steroids. Likewise, GMA at appropriate intervals in patients at a high risk of clinical relapse suppresses relapse thus sparing the patients from the morbidity associated with IBD relapse. Further, GHA appears to reduce the number of patients being submitted to colectomy or exposure to unsafe immunosupressants. First UC episode, steroid naivety and short disease duration appear good predictors of response to GMA and based on the available data, GMA seems to have an excellent safety profile. 展开更多
关键词 Inflammatory bowel disease Ulcerative colitis Crohn's disease Selective leukocytapheresis Aclacolumn Intedeukin 10 Intefleukin-1 receptor antagonist
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Nutritional status and nutritional therapy in inflammatory bowel diseases 被引量:47
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作者 Corina Hartman Rami Eliakim Raanan Shamir 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第21期2570-2578,共9页
Underweight and specific nutrient deficiencies are frequent in adult patients with inflammatory bowel disease(IBD).In addition,a significant number of children with IBD,especially Crohn's disease(CD) have impaired... Underweight and specific nutrient deficiencies are frequent in adult patients with inflammatory bowel disease(IBD).In addition,a significant number of children with IBD,especially Crohn's disease(CD) have impaired linear growth.Nutrition has an important role in the management of IBD.In adults with CD,enteral nutrition(EN) is effective in inducing clinical remission of IBD,although it is less efficient than corticosteroids.Exclusive EN is an established primary therapy for pediatric CD.Limited data suggests that EN is as efficient as corticosteroids for induction of remission.Additional advantages of nutritional therapy are control of inflammation,mucosal healing,positive benefits to growth and overall nutritional status with minimal adverse effects.The available evidence suggests that supplementary EN may be effective also for maintenance of remission in CD.More studies are needed to confirm these findings.However,EN supplementation could be considered as an alternative or as an adjunct to maintenance drug therapy in CD.EN does not have a primary therapeutic role in ulcerative colitis.Specific compositions of enteral dietselemental diets or diets containing specific components-were not shown to have any advantage over standard polymeric diets and their place in the treatment of CD or UC need further evaluation.Recent theories suggest that diet may be implicated in the etiology of IBD,however there are no proven dietary approaches to reduce the risk of developing IBD. 展开更多
关键词 Inflammatory bowel disease Crohn'sdisease Ulcerative colitis ADULTS CHILDREN MALNUTRITION Growth disorders Nutrition therapy
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Evidence for the role of gastric mucosa at the secretion of soluble triggering receptor expressed on myeloid cells(strem-1) in peptic ulcer disease 被引量:11
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作者 Vassilios Koussoulas Spyridon Vassiliou +5 位作者 Ekaterini Spyridaki Maria Demonakou Ilia Vaki Charalambos Barbatzas Helen Giamarellou Evangelos J Giamarellos-Bourboulis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第34期4610-4614,共5页
AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer.METHODS: Seventy two patients were enrolled; 35 with duodenal, 22 with gastric ulcer and 26 with chronic gastritis. Patients... AIM: To investigate the role of gastric mucosa at the secretion of sTREM-1 in peptic ulcer.METHODS: Seventy two patients were enrolled; 35 with duodenal, 22 with gastric ulcer and 26 with chronic gastritis. Patients were endoscoped and gastric juice was aspirated. Patients with duodenal and gastric ulcer underwent a second endoscopy post-treatment. Biopsies were incubated in the absence/presence of endotoxins or gastric juice. Supernatants were collected and sTREM-2 and TNF~ were measured by enzyme immunoabsorbent assays. Scoring of gastritis was performed before and after treatment according to updated Sydney score.RESULTS: Patients with duodenal and gastric ulcer and those with chronic gastritis had similar scores of gastritis, sTREM-1 was higher in supernatants of tissue samples of H pylori-positive than of H pylori-negative patients with gastric ulcer. Median (± SE) sTREM-1 was found increased in supernatants of patients with gastric ulcer before treatment (203.21 ± 88.91 pg/1000 cells) compared to supernatants either from the same patients post-treatment (8.23 ± 5.79 pg/1000 cells) or from patients with chronic gastritis (6.21 ± 0.71 pg/1000 cells) (P 〈 0.001 and 〈 0.001, respectively). Similar differences for sTREM-1 were recorded among LPS-stimulated tissue samples of patients (P = 0.001). Similar differences were not found for TNFα. Positive correlations were found between sTREM-1 of supernatants from patients with both duodenal and gastric ulcer before treatment and the degree of infiltration of neutrophils and monocytes.CONCLUSION: sTREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer, sTREM-1 was released at the presence of H pylori from the inflamed gastric mucosa in the field of gastric ulcer. 展开更多
关键词 STREM-1 Chronic gastritis Gastric ulcer Duodenal ulcer
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Haemostatic system in inflammatory bowel diseases:New players in gut inflammation 被引量:18
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作者 Franco Scaldaferri Stefano Lancellotti +1 位作者 Marco Pizzoferrato Raimondo De Cristofaro 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第5期594-608,共15页
Inflammation and coagulation constantly influence each other and are constantly in balance.Emerging evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important... Inflammation and coagulation constantly influence each other and are constantly in balance.Emerging evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities occur.The aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level.Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed. 展开更多
关键词 Activated protein C COAGULATION Crohn'sdisease INFLAMMATION Inflammatory bowel disease PLATELETS Ulcerative colitis
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Effect of smoking on inflammatory bowel disease: Is it disease or organ specific? 被引量:7
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作者 A Karban R Eliakim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第15期2150-2152,共3页
Smoking is an important environmental factor in inflammatory bowel disease (IBD) with differing effects in ulcerative colitis (UC) and Crohn's disease (CD). Never smoking and formerly smoking increase the risk ... Smoking is an important environmental factor in inflammatory bowel disease (IBD) with differing effects in ulcerative colitis (UC) and Crohn's disease (CD). Never smoking and formerly smoking increase the risk of UC, whereas smoking exacerbates the course of CD. The potential mechanisms involved in this dual relationship are yet unknown. A reasonable assumption is that smoking has different effects on the small and large intestine. This assumption is based on animal and human studies that show that the effects of smoking/nicotine on CD and UC depend on the site of inflammation and not on the type of disease. 展开更多
关键词 NICOTINE SMOKING Crohn's disease Ulcerative Colitis Small bowel COLON
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Immunopathogenesis of inflammatory bowel disease 被引量:46
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作者 David Q Shih Stephan R Targan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第3期390-400,共11页
Crohn's disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that ... Crohn's disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn's disease and T-helpero2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. 展开更多
关键词 Crohn's disease Ulcerative colitis Innate andadaptive immune system
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Recent trends in the surgical management of inflammatory bowel disease 被引量:10
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作者 Robert E Roses John L Rombeau 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第3期408-412,共5页
Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have... Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have occurred in surgery. Advances in CD include an emphasis upon conservatism as exemplified by more limited resections, strictureplasties, and laparoscopic resections. The use of probiotics in selected patients has improved the outcome in patients with pouchitis following restorative proctocolectomy for UC. It is anticipated that ongoing discoveries in the molecular basis of IBD will in turn identify those patients who will best respond to surgery. 展开更多
关键词 Crohn's disease Ulcerative colitis Ileal pouchanal anastomosis Laparoscopic colectomy
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Ileal pouch surgery for ulcerative colitis 被引量:10
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作者 Simon P Bach Neil J Mortensen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第24期3288-3300,共13页
Ulcerative colitis (UC) is a relapsing and remitting disease characterised by chronic mucosal and submucosal inflammation of the colon and rectum. Treatment may vary depending upon the extent and severity of inflammat... Ulcerative colitis (UC) is a relapsing and remitting disease characterised by chronic mucosal and submucosal inflammation of the colon and rectum. Treatment may vary depending upon the extent and severity of inflammation. Broadly speaking medical treatments aim to induce and then maintain remission. Surgery is indicated for inflammatory disease that is refractory to medical treatment or in cases of neoplastic transformation. Approximately 25% of patients with UC ultimately require colectomy. Ileal pouch-anal anastomosis (IPAA) has become the standard of care for patients with ulcerative colitis who ultimately require colectomy. This review will examine indications for IPAA, patient selection, technical aspects of surgery, management of complications and long term outcome following this procedure. 展开更多
关键词 Ulcerative colitis Ileal Pouch Ileal pouch anal anastomosis
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Recent results of laparoscopic surgery in inflammatory bowel disease 被引量:7
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作者 Hermann Kessler Jonas Mudter Werner Hohenberger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第9期1116-1125,共10页
Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical... Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional approach.Inflammatory alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed laparoscopically.The current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is presented.CD limited to the terminal ileum has become a common indication for laparoscopic surgical therapy.In severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative time.Studies comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic approach.Even complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low morbidity.In UC, restorative proctocolectomy is the standard procedure in elective surgery.The demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various studies.An increased body mass index and acute inflammation of the bowel may be relative contraindications.Short and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic surgery.Multiple studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under investigation.Technical considerations are playing an important role for the complexity of both diseases. 展开更多
关键词 Crohn’s disease Ulcerative colitis LAPAROSCOPIC COLORECTAL SURGERY
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