思密达治疗溃疡性结肠炎腹泻的机制和疗效

目的探讨思密达治疗溃疡性结肠炎腹泻的机制和疗效。方法选取来我院进行治疗的溃疡性结肠炎腹泻患者80例，男48例，女32例，年龄10～25岁，平均年龄为（28．7±11．2）岁。将80例患者按照随机原则进行分组，治疗组与对照组各40例。治疗组40例患者给予口服思密迟进行治疗，对照组40例患者给予口服柳氮磺砒啶进行治疗，治疗组和对照组患者均进行持续2周时间的治疗。观察对比两组患者的腹泻症状改善情况、临床总有效率以及不良反应情况。结果思密达能够直接对损伤的肠黏膜进行修复，这是其治疗溃疡性结肠炎腹泻的主要机制。两组患者经过临床治疗之后，治疗组忠者的腹泻症状改善时间显著短于对照组患者，比较差异具有统计学意义（P〈0．05）；治疗组患者的临床总有效率为82．5％，对照组患者的临床总有效率92．5％，比较差异具有统计学意义（P〈0．05）；治疗组患者不良反应发生率为5％，对照组患者不良反应发生率为15％，比较差异具有统计学意义（P〈0．05）。结论思密达通过有效修复损伤肠黏膜的机制，能够对溃疡性结肠炎腹泻起到良好的疗效，且安全无毒副作用。

思密达治疗溃疡性结肠炎腹泻疗效观察

目的:观察分析思密达治疗溃疡性结肠炎腹泻的临床效果。方法:选取溃疡性结肠炎患者共142例,随机将患者分为观察组和对照组两组,其中观察组患者采用思密达为主要治疗药物,共70例;对照组则采用柳氮磺砒啶作为主要治疗药物。结果:观察组的治疗有效率为91.4%,对照组的治疗有效率为79.2%,两组对比差异有统计学意义(P<0.05);而对照组患者的脓血便和腹泻症状消失时间明显要长于观察组患者,两组对比差异有统计学意义(P<0.05)。结论:思密达能够有效治疗溃疡性结肠炎腹泻,并且有效缩短症状持续时间,减少病原菌对肠道黏膜的损伤,改善黏膜情况。

思密达治疗溃疡性结肠炎腹泻的机制和疗效

目的探讨在治疗溃疡性结肠炎过程中使用思密达的疗效。方法从2013年5月—2015年10月来该院治疗溃疡性结肠炎腹泻的患者中方便选出92例,将其分为两个小组。对其中一组患者采用柳氮磺吡啶治疗,作为对比组;对另外一组则采用思密达治疗,作为研究组。分别记录两组患者治疗效果、粪便异常恢复时间和排便次数恢复时间。结果研究组治疗总有效率为95.65%(44/46),明显高于对比组80.43%(37/46),同时研究组患者粪便异常恢复时间、排便次数恢复时间均明显短于对比组。两组数据差异具有统计学意义(P<0.05)。结论思密达可以有效提高溃疡性结肠炎腹泻患者的治疗效果,并缩短其恢复时间。

思密达治疗溃疡性结肠炎腹泻的应用效果及作用机制分析

目的:探究思密达治疗溃疡性结肠炎腹泻的临床效果。方法:选择2014年6月-2015年6月来我院就诊的108例溃疡性结肠炎患者临床资料为研究对象,将其分成两组,对照组使用柳氮磺砒啶进行治疗,观察组患者使用思密达进行治疗,半个月后,对比两组患者的治疗有效率和临床症状改善情况。结果:和对照组相比,观察组患者临床症状改善情况明显较好,组间数据存在统计学意义,p<0.05.从治疗效果上来分析,对照组患者治疗总有效率为87.04%,观察组为96.30%,p<0.05。结论:在治疗溃疡性结肠炎腹泻疾病方面,思密达能够全面改善患者临床症状,令其取得满意治疗效果,因此值得在进一步推广使用。

Observation on the effects of different partitioned moxibustion in treating ulcerative colitis

Objective：To observe the clinical effect and syndrome scores improvements of herbal cake-partitioned moxibustion（HPM） and ginger-partitioned moxibustion（GPM） in treating ulcerative colitis（UC）.Methods：A total of 65 eligible cases were randomly divided into a HPM group（n=32） and a GPM group（n=33） according to their visiting order.Bilateral Tianshu（ST 25） and Dachangshu（BL 25） were selected for the HPM or the GPM treatment once daily,12 d as a treatment course with a 3-day interval,6 courses in all.The clinical effect,syndrome scale and Mayo scale were evaluated and compared between the two groups.Results：Of the 65 cases enrolled,2 cases dropped out in the HPM group and 3 cases dropped out in the GPM group,30 cases of each group finished the treatment courses.The total effective rate is 93.3% in HPM group and 86.7% in the GPM group,there was no statistically significant difference in the total effective rate between the two groups（P〉0.05）;there were statistically significant differences between the two groups in score evaluation of lasting time of abdominal pain and frequency of diarrhea,HPM is prior to GPM（P=0.032,P=0.044）.There are no statistical significant differences between the two groups in scores evaluation of general symptom,three main symptoms,quality of life（QOL）,frequency and severity of abdominal pain,times,and pattern of diarrhea（all P〉0.05）.There was a statistical significant difference in the improvement of Mayo score between the two groups,and HPM was superior to GPM（P=0.048）.Conclusion：HPM and GPM are both promising ways to treat UC,and the total effect is quite similar.HPM is superior to GPM in the improvement of lasting time of abdominal pain and frequency of diarrhea,and also the Mayo score.

Clinical Research of Ulcerative Colitis Treated with Herbal Cake-partitioned Moxibustion

Objective： To observe the effects of herbal cake-partitioned moxibustion and bran-partition moxibustion in improving symptoms of ulcerative colitis （UC） and the TNF-α and its receptor of colon mucosa. Method： 67 UC cases were randomly allocated into herbal cake-partition moxibustion group of 35 cases and bran-partitioned moxibustion group of 32 cases, to compare the improvement and detect the TNF-α and its receptor with immunohistochemical method in both groups. Result： Herbal cake-partitioned moxibustion is prior to bran-partitioned moxibustion in improving of diarrhea, flatus, lassitude, tenesmus and lumbar soreness; The expression of TNF-α,TNF-αR1, and TNF-αR2 are significantly decreased after treatment in herbal cake-partitioned moxibustion group, while in bran-partitioned moxibustion group only TNF-αR1 expression is significant decreased after treatment. Conclusion： Moxibustion can well improve the syndromes of UC, Herbal cake-partitioned Moxibustion is prior to bran-partitioned moxibustion in the improvement of diarrhea and flatus; Herbal cake-partitioned moxibustion could down-regnlate the expression of TNF-α,TNF-αR1, and TNF-αR2, while bran-partitioned moxibustion could only down-regulate the expression of TNF-αR1.