2-Amino-5-methylbenzoic acid（1） was acylated with acyl chlorides,then heated（together） with（acetic） anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one（3a3b）,while compound 1 was （reacted） with p...2-Amino-5-methylbenzoic acid（1） was acylated with acyl chlorides,then heated（together） with（acetic） anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one（3a3b）,while compound 1 was （reacted） with propanoic anhydride or trifluoroacetic anhydride to give 2-ethyl or 2-trifluoromethyl-6-methylbenzoxazin-4-one（3c3d） directly. Then,2-substituted 6-methylbenzoxazin-4-ones（3a3d） were heated together with formamide to afford 2-substituted 6-methyl-4（3H）-quinazolinones（4a4d）,which were（converted） into the title compounds（5a5d） via brominating with N-bromosuccinimide in the presence of （PhCOO）2.The structures of all the intermediates and final products were confirmed with ESI-MS,1H NMR and elemental analysis.展开更多
A flow injection chemiluminescence method for the determination of Cefepime hydrochloride is descrbed.The method is based on the chemiluminesence emitted during the oxidation of Cefepime hydrochloride by N-bromosuccin...A flow injection chemiluminescence method for the determination of Cefepime hydrochloride is descrbed.The method is based on the chemiluminesence emitted during the oxidation of Cefepime hydrochloride by N-bromosuccinimide（NBS）in alkaline medium in the presence of fluorescein as energy transfer.The chemiluminescence intensity is proportional to cefepime hydrochloride concentration over the range 0.05mg·L-110mg·L-1.The detection limit is 29μg.L-1and the relative standard deviation is 4.3% for 5mg·L-1cefepime hydrochloride（n=11）.This method had been successfully applied to determination of cefepime hydrochloride in injections.展开更多
文摘2-Amino-5-methylbenzoic acid（1） was acylated with acyl chlorides,then heated（together） with（acetic） anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one（3a3b）,while compound 1 was （reacted） with propanoic anhydride or trifluoroacetic anhydride to give 2-ethyl or 2-trifluoromethyl-6-methylbenzoxazin-4-one（3c3d） directly. Then,2-substituted 6-methylbenzoxazin-4-ones（3a3d） were heated together with formamide to afford 2-substituted 6-methyl-4（3H）-quinazolinones（4a4d）,which were（converted） into the title compounds（5a5d） via brominating with N-bromosuccinimide in the presence of （PhCOO）2.The structures of all the intermediates and final products were confirmed with ESI-MS,1H NMR and elemental analysis.
文摘A flow injection chemiluminescence method for the determination of Cefepime hydrochloride is descrbed.The method is based on the chemiluminesence emitted during the oxidation of Cefepime hydrochloride by N-bromosuccinimide（NBS）in alkaline medium in the presence of fluorescein as energy transfer.The chemiluminescence intensity is proportional to cefepime hydrochloride concentration over the range 0.05mg·L-110mg·L-1.The detection limit is 29μg.L-1and the relative standard deviation is 4.3% for 5mg·L-1cefepime hydrochloride（n=11）.This method had been successfully applied to determination of cefepime hydrochloride in injections.
