CT引导下经皮芯针活检检测骨病变的影响因素分析

目的探讨CT引导下经皮芯针活检（coreneedlebiopsy，CNB）检测骨病变的影响因素。方法回顾性分析笔者医院进行CT引导下经皮CNB检测骨病变的患者124例，对患者年龄、性别、病变部位、病变类型、组织样本大小和病变直径进行单因素分析；对单因素分析结果中有意义的病变类型和病变直径这两个因素进行Logistic多因素分析用该方法检测骨病变的影响因素。结果单因素分析结果显示病变类型和病变直径是CT引导下经皮CNB检测骨病变的两个影响因素。溶骨性骨病变（检出率94．5％）较硬化性骨病变（检出率94．5％）更易被检出（P〈0．05），其被检出的可能性约为硬化性骨病变的10倍（OR=10．37，95％CI：4．21～35．69）；骨病变直径≥3cm（检出率95．1％）较病变直径〈3cm（检出率79．2％）更易被检出（P〈0．05），其被检出的可能性约为病变直径〈3cm的5倍（OR=5．02，95％CI：1．78—18．29）。结论骨病变类型和病变直径是CT引导下经皮CNB检测骨病变的影响因素，溶骨性骨病变和病变直径≥3cm具有较高的检出率。

Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors.Here,we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine(CQ)-loaded polydopamine nanoparticles(PPA/CQ)for efficient treatment of bone tumors via breaking the vicious cycle.The nanoparticles were efficiently accumulated to the bone tissues,especially the osteolytic lesions around tumors.CQ released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor(TNF)receptor-associated receptor 3 to attenuate the osteolysis in bone tumors.On the other hand,CQ blocked the autophagy in cancer cells,resulting in improved photothermal killing of cancer cells.Finally,the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis.This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.