A new roll shifting strategy with varying stroke and varying step was investigated,Two characteristic parameters including cat ear height and gap contour smoothness were introduced to assess the effect of shifting str...A new roll shifting strategy with varying stroke and varying step was investigated,Two characteristic parameters including cat ear height and gap contour smoothness were introduced to assess the effect of shifting strategy on roll wear,and the relation between characteristic parameters and shifting strategy was established.Both varying stroke and varying step can reduce cat ear height and gap contour smoothness,so the shifting strategy with varying stroke and varying step is better than the one with either varying stroke or varying step,Based on the effect of shifting control parameters on characteristic parameters of roll wear,the selection principle of these shifting control parameters was gained.A case study was conducted to validate the proposed roll shifting strategy,reducing uncontrollable quartic loading gap contour,improving strip profile and extending rolling length of a rolling campaign.展开更多
Circulating leukocytes in trafficking to the inflammatory sites, will be first tether to, and then roll on the vascular surface. This event is mediated through specific interaction of P-selectin and P-selectin glycopr...Circulating leukocytes in trafficking to the inflammatory sites, will be first tether to, and then roll on the vascular surface. This event is mediated through specific interaction of P-selectin and P-selectin glycoprotein ligand-1 （PSGL-1）, and regulated by hemodynamics. Poor data were reported in understanding P-selectin-mediated rolling. With the flow chamber technique, we herein observed HL-60 cell rolling on P-selectin with or without 3% Ficoll at various wall shear stresses from 0.05 to 0.4 dyn/cm：. The results demonstrated that force rather than transport regulated the rolling, similar to rolling on L- and E-selectin. The rolling was accelerated quickly by an increasing force below the optimal shear threshold of 0.15 dyn/cm2 first and then followed by a slowly decelerating phase starting at the optimum, showing a catch-slip transition and serving as a mechanism for the rolling. The catch-slip transition was completely reflected to the tether lifetime and other rolling parameters, such as the mean and fractional stop time. The narrow catch bond regime stabilized the rolling quickly, through steeply increasing frac- tional stop time to a plateau of about 0.85. Data presented here suggest that the low shear stress threshold serves as a mecha- nism for most cell rolling events through P-selectin.展开更多
基金Project(50974039) supported by the National Natural Science Foundation of China
文摘A new roll shifting strategy with varying stroke and varying step was investigated,Two characteristic parameters including cat ear height and gap contour smoothness were introduced to assess the effect of shifting strategy on roll wear,and the relation between characteristic parameters and shifting strategy was established.Both varying stroke and varying step can reduce cat ear height and gap contour smoothness,so the shifting strategy with varying stroke and varying step is better than the one with either varying stroke or varying step,Based on the effect of shifting control parameters on characteristic parameters of roll wear,the selection principle of these shifting control parameters was gained.A case study was conducted to validate the proposed roll shifting strategy,reducing uncontrollable quartic loading gap contour,improving strip profile and extending rolling length of a rolling campaign.
基金supported by the National Natural Science Foundation of China(Grant Nos.11272125,11072080,31170887 and 31200705)Guangdong Natural Science Foundation(Grant No.S2011010005451)Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20110172110030)
文摘Circulating leukocytes in trafficking to the inflammatory sites, will be first tether to, and then roll on the vascular surface. This event is mediated through specific interaction of P-selectin and P-selectin glycoprotein ligand-1 （PSGL-1）, and regulated by hemodynamics. Poor data were reported in understanding P-selectin-mediated rolling. With the flow chamber technique, we herein observed HL-60 cell rolling on P-selectin with or without 3% Ficoll at various wall shear stresses from 0.05 to 0.4 dyn/cm：. The results demonstrated that force rather than transport regulated the rolling, similar to rolling on L- and E-selectin. The rolling was accelerated quickly by an increasing force below the optimal shear threshold of 0.15 dyn/cm2 first and then followed by a slowly decelerating phase starting at the optimum, showing a catch-slip transition and serving as a mechanism for the rolling. The catch-slip transition was completely reflected to the tether lifetime and other rolling parameters, such as the mean and fractional stop time. The narrow catch bond regime stabilized the rolling quickly, through steeply increasing frac- tional stop time to a plateau of about 0.85. Data presented here suggest that the low shear stress threshold serves as a mecha- nism for most cell rolling events through P-selectin.
