扶土抑木导滞法治疗慢性迁延性肝炎30例观察

目的观察扶土抑木导滞法治疗“慢性迁延性肝炎”的临床疗效。方法将50例慢性迁延性肝炎患者随机分为两组。对照组20例口服肝泰乐、护肝片,肌苷,静脉滴注能量合刑治疗;治疗组30例配合中药汤剂治疗(基本方:太子参、苍白术、云苓、查肉、陈皮、贯众、白毛藤、茵陈、虎仗、大黄、柴胡、枳壳、郁金)。观察两组临床疗效及主要症状、体征、肝功等改善情况。结果治疗组显效25例,有效4例,无效1例,总有效率为96.6%;对照组显效9例,有效5例,无效6例,总有效率为70%。两组显效率,总有效率比较,差异均有显著意义。结论扶土抑木导滞法治疗慢性迁延性肝炎,能有效改善患者临床症状、体征、恢复肝功能有较好疗效。

张瑞图书法成就与其仕途关系研究

本文从张瑞图的仕途履历对其书法成就的助推与滞抑两个方面论述张的仕途与其书法成就的密不可分。同时指出其虽位列"阉党"名录,但针对他的"人品论"可以休矣,并由此提出在品评其书作时,须将其作品与其人"强行"分割开来的观点。

A traditional Chinese medicine Huaier triggers G1 cell cycle arrest and apoptosis through cyclins-CDKs-CKIs machinery in MOLT4 cells

Objective: The purpose of the study was to study the effect of Huaier, a traditional Chinese medicine, on the cell cycle adjustment in MOLT4 cells in vitro. Methods: We used MTT assay to test cell viability, flow cytometry to detect cell cycle and apoptosis and western blot to examine the expression of cell-cycle and apoptotic proteins in MOLT4 cells induced by Huaier. Results: Huaier could reduce the viability of MOLT4 cell by inducing G1 arrest and apoptosis. The induction of apoptosis after treatment with Huaier for 24 h was demonstrated in a dose- and time-dependent manner by flow cytometry analysis. G1 arrest induced by Huaier was modulated through the increased expression of Cdki proteins(p21cip/waf1 and p27kip1) with a simultaneous decrease in Cdk2, Cdk4, Cdk6, cyclin D1 and cyclin E expression. Huaier also induced Bax and Bcl-2 expression and activation of Caspase-3. Conclusion: It is firstly demonstrated that Huaier can inhibit proliferation of MOLT4 cells via G1 arrest and apoptosis. These results suggest that Huaier is a cell-cycle anti-cancer drug.

Analysis and suppression of hysteresis effect in semi-actively controlled MR-suspension

Magneto-rheological (MR) fluid-based dampers are currently being explored for their potential implementation in intelligent vehicle suspension designs. Due to inherent hysteretic force properties of the MR dampers, analyzing and suppressing the MR-damper hysteresis effects, therefore, impose a great challenge. A quarter-vehicle MR-suspension model is formulated in conjunction with proposed hysteretic and mean MR-damper models, and the passive and semi-actively controlled MR-suspension systems are focused to investigate the influence of MR-damper force hysteresis. The semi-actively controlled MR-suspension employs the “on-off” control law in response to direction of the damper velocity, so as to generate the asymmetric damping force property form the symmetric MR-damper design. The results show that the MR-damping hysteresis yields serious transients and oscillations in responses for the semi-actively controlled MR-suspension than the passive MR-suspension due to the current-switching discontinuity, and would thus deteriorate the suspension performance. The undesired strong transients and oscillations in responses can be effectively suppressed by employing the proposed smooth technique without phase shift for modulating the command current discontinuity.

Inappropriate use of digoxin in patients presenting with digoxin toxicity

Background Digoxin remains widely used today despite its narrow therapeutic index and toxicity. The objective of this study was to investigate the percentage of inappropriate use of digoxin and long-term outcomes of elderly patients hospitalized for digoxin toxicity. Methods The study included 99 consecutive patients hospitalized for digoxin toxicity. The other study criteria for the inappropriate use of digoxin was regarded if participants having depressed left ventricular systolic function （ejection fraction 〈 45%） who were not on optimal medical therapy including beta-blocker and angiotensin-converting-enzyme inhibitor therapy or if participants having permanent AF who were not on optimal beta-blocker therapy. Results Appropriate digoxin usage was confirmed in 33 of patients in spite of its narrow therapeutic index. A total of 16 of 99 patients died, with a mean follow-up time of 22.1 ± 10.3 months. Conclusions Contrary to popular belief, the rate of inappropriate digoxin usage remains high. On account of its narrow therapeutic index and toxicity, digoxin should be used more carefully according to the current evidence and guidelines.

Influence of Erbanxiao solution on inhibiting angiogenesis in stasis toxin stagnation of non-small cell lung cancer

OBJECTIVE： To investigate the effects and mecha- nisms of Erbanxiao solution in inhibiting tumor an- giogenesis. METHODS： We observed the effects and mecha- nisms of Chinese medicines on inhibiting tumor an- giogenesis and studied the theories and results of treatment. Sixty patients with lung cancer were ran- domized into two groups （n=30）. Patients in the control group were given compound Kushen injec- tion, and patients in the treatment group were giv- en Erbanxiao solution. The effect of Erbanxiao solu- tion on vascular endothelium growth factor （VEGF）, basic fibroblast growth factor （bFGF）, and tumor ne- crosis factor-α （TNF-α） was observed. RESULTS： The effective rate of the treatment group was 60% while the control group was 36%. There was a significant difference between the twogroups （P〈0.05）. VEGF, bFGF, and TNF-a levels of the two groups were significantly different before and after treatment （P〈0.01）. These Traditional Chi- nese Medicines significantly inhibited tumor angio- genesis, possibly by changing levels of VEGF, bFGF, and TNF-α. CONCLUSION： It is necessary to further explore the potential of Traditional Chinese Medicine in the treatment of angiogenesis in tumor patients.

Effect comparason of thermosensitive moxibustion and estazolam on anxiety and depression in the patients of insomnia differentiated as liver qi stagnation

Objective： To observe the effect of thermosensitive moxibustion on anxiety and depression in the patients of insomnia differentiated as liver qi stagnation.Methods： From January 2015 to January 2017, 60 patients of insomnia differentiated as liver qi stagnation were collected in Shijiazhuang Municipal Chinese Medicine Hospital. According to the random number table, the patients were randomized into a moxibustion group（30 cases） and an estazolam group（30 cases）. In the moxibustion group, the thermosensitive moxibustion was adopted alternatively to the bilateral yuan-source points of the liver and gallbladder meridians. In the estazolam group, estazolam, 1 mg was prescribed for oral administration before sleep every day. After 15-day treatments, the sleep quality, the severity of anxiety and depression and the therapeutic effects were observed before and after treatment in the two groups.Results： Before treatment, the differences were not significant in the scores of Pittsburgh sleep quality index（PSQI）, the self-rating anxiety scale（SAS） and the self-rating depression scale（SDS） between the two groups（all P〉0.05）. After treatment, the scores of PSQJ, SAS and SDS were all reduced remarkably as compared with those before treatment in the two groups（all P〈0.05）. PSQI score was（6.72 ±2.311）points in the moxibustion group and was（5.37 ±2.621） points in the estazolam group. SAS score was（31.76 ± 6.511） points in the moxibustion group and was（39.62 ± 4.371） points in the estazolam group.SDS score was（35.98 ±5.161） points in the moxibustion group and was（46.38 ±4.971） points in the estazolam group. After treatment, the scores of PSQI, SAS and SDS in the moxibustion group were reduced more remarkably as compared with the estazolam group, indicating the significant differences（all P 〈0.05）. After treatment, the scores of sleep efficacy and TCM symptoms were（72.65 ± 14.36） points and（69.36 ±4.28） points respectively in the moxibustion group, better than the estazolam group, indicating the significant differences（all P〈0.05）.Conclusion： The thermosensitive moxibustion at the yuan-source points of the liver and gallbladder meridians significantly improves the sleep quality, relieves the symptoms of anxiety and depression and enhances the therapeutic effects in the patients of insomnia differentiated as liver qi stagnation. Hence,this therapy deserves to be recommended in clinical practice.