本文介绍了GAMBRO AK 200 ULTRA S血透滤过机的工作原理,列举了2例故障案例,其故障提示分别为“UF SELF TEST FAILED,New test within 5 min”及“FLUID TUBES FOR LEAKAGE,Press LOW to confirm”。通过分析可能的故障原因,运用气泡跟...本文介绍了GAMBRO AK 200 ULTRA S血透滤过机的工作原理,列举了2例故障案例,其故障提示分别为“UF SELF TEST FAILED,New test within 5 min”及“FLUID TUBES FOR LEAKAGE,Press LOW to confirm”。通过分析可能的故障原因,运用气泡跟踪法及压力变化进行漏气检修,逐步排查,分别采取更换FOVA电磁阀阀膜及清理ZEVA电磁阀阀膜、更换旁路管采样口的措施排除故障。本文通过分析不同的故障类型,介绍不同的漏气检修方法,给维修工程师提供参考,并提示做好预防性维护,定期更换易损件,以此降低故障发生率。展开更多
GamBro AK 200 ULTRA S透析机是百特金宝公司生产的双泵透析机,以血液透析滤过功能为特色,兼备血液透析、血液滤过的功能。通常,操作人员在使用过程中的操作失误,会以报警提示的形式呈现,操作人员根据报警提示的引导,即可快速更正操作,...GamBro AK 200 ULTRA S透析机是百特金宝公司生产的双泵透析机,以血液透析滤过功能为特色,兼备血液透析、血液滤过的功能。通常,操作人员在使用过程中的操作失误,会以报警提示的形式呈现,操作人员根据报警提示的引导,即可快速更正操作,报警提示普遍与操作失误相关,然而,也有掩藏在“报警提示”表面下的特殊故障,本文对一例该类特殊故障的检修进行解析。展开更多
The face velocities of the high efficiency particulate air filters and the ultra low penetration airfilters in fan filter units (FFUs) have large relative standard deviation and turbulivity. It seriously affects the ...The face velocities of the high efficiency particulate air filters and the ultra low penetration airfilters in fan filter units (FFUs) have large relative standard deviation and turbulivity. It seriously affects the unidirectivity of the flow in the unidirectional flow clean zone and cleanroom. The cross contamination in this kind of unidirectional flow area is hardly controlled. It is significant to find optional method for keeping the face velocity uniformity of FFU and reducing the face velocity turbulivity of FFU, furthermore, to keep the cleanliness level under FFUs. The normal and easy method is to add flow rectifiers under filters. FFUs with various flow rectifiers have been tested. The uniformity and turbulivity of facevelocity under the FFU are presented in this paper. The influence of the facevelocity uniformity and turbulivity on the contamination boundary of the unidirectional flow is studiedas well.展开更多
A monitoring system is an important guarantee of safety in a production mine. However, not all monitoring substations pass the electrical fast transient/burst (EFT/B) immunity test and the explosion-proof test simul...A monitoring system is an important guarantee of safety in a production mine. However, not all monitoring substations pass the electrical fast transient/burst (EFT/B) immunity test and the explosion-proof test simultaneously. To enhance the immunity, the values of capacitance and inductance should be increased, which are actually limited by coal mine explosion-proof standards. Hence, for the first time, an active filter was applied in an electromagnetic interference (EMI) output filter. As a result, the interference within 30 MHz clearly weakened, but the frequency spectrum had a wide range. An EMI input filter and ferrite beads were adopted to restrain higher frequency interference. An output interference spectrogram of the substation was obtained with an analyzer. The results indicate that the improved complex filtering markedly help to control interference. With the support of improved complex filtering and other enhancing immunity means about I/O ports, the substation managed to pass both the EFT/B immunity test and the explosion-proof test synchronously. We conclude that improved complex filtering is of vital importance in enhancing the electromagnetic compatibilitv (EMC) of the coal mine monitoring system.展开更多
Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detect...Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results: In the 62 bladder cancers, the positive rate of PTEN was 53.2% (33/62). All 18 normal bladder tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades (P〈0.05). Conclusion: The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis.展开更多
AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±...AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage.展开更多
Based on the realization of moving-bed cake filtering, the concepts of static-bed filtering time and moving-bed fil- tering time in the helical-conveyor fine coal filtering centrifuge were proposed, and the mathematic...Based on the realization of moving-bed cake filtering, the concepts of static-bed filtering time and moving-bed fil- tering time in the helical-conveyor fine coal filtering centrifuge were proposed, and the mathematic relations between the time defined and the main factors related were studied in detail. The results show that the static-bed filtering time is the function of the spiral heads and the rotation rate deference between the spiral and the porous drum, while the moving-bed filtering time is the function of the cone angle of the porous drum, the radius of the porous drum, the spiral angle, and the rotation rate deference. The functions deduced are of great significance for fine coal filtering centrifuge's parameters determining and optimizing. It is shown that the filtering centrifuge with smaller spiral angle, smaller rotation rate deference, and smaller cone angle may do a better job for fine coal dewatering.展开更多
The mechanical dewatering of activated sludge is troublesome due to its high compressibility of solids. The dewatering can be enhanced dramatically by the use of electroosmosis,in which an electric field is applied to...The mechanical dewatering of activated sludge is troublesome due to its high compressibility of solids. The dewatering can be enhanced dramatically by the use of electroosmosis,in which an electric field is applied to the sludge cake.In this study,the influence of filter cloth on the cathode on the dewatering of activated sludge was investigated.It was found that thicker filter cloth led to lower water removal from the sludge cake,so a stainless steel cathode net with small pore size instead of filter cloth was applied,which improves the dewatering efficiency and reduces the electric power consumption.Moreover,water absorbent materials were helpful to remove the water from the sludge cake.For the electroosmotic dewatering at 7 kPa and 24 V·cm-1,the water content in the sludge cake decreased to 60%(by mass) with the average 0.075 kW·h·kg-1of water removed by using the cathode net.展开更多
OBJECTIVE To explore the expression and significance of the tumor metastatic suppressor gene the KAI1 and Ki67 antigen in bladder transitional cell carcinoma (BTCC). METHODS Two-stepped immuno-histochemical staining...OBJECTIVE To explore the expression and significance of the tumor metastatic suppressor gene the KAI1 and Ki67 antigen in bladder transitional cell carcinoma (BTCC). METHODS Two-stepped immuno-histochemical staining was used to detect the expression of the KAI1 protein and Ki67 antigen. The reverse transcription polymerase chain reaction (RT-PCR) was used to detect the KAI1 mRNA in 54 BTCC specimens and 32 normal bladder counterparts. 13-actin was the internal control. RESULTS The KAI1 protein was mainly expressed on cell membranes at cell-to-cell borders, with uniform and continuous staining in normal bladder transitional epithelium. However, the number of positive-staining cells was greatly decreased in BTCC epithelium, and with an increase in the stage and Grade and appearance of lymph node metastasis the staining was non-uniform and discontinuous. The Ki67 antigen was expressed in the nucleus, and with an increase in the stage and Grade and appearance of lymph node metastasis, the Ki67 expression increased. The Ki67 antigen was negatively related to the expression of KAI1 (P〈0.01).The expression level of KAI1 mRNA was much greater in normal bladder transitional epithelium compared to BTCC, moreover, with an increase in the Grade, infiltration depth and appearance of lymph node metastasis, the expression of KAI1 mRNA was reduced. CONCLUSION The expression of KAI1 protein may be used as a prognostic marker to indicate the degree of infiltration and metastasis. Measurement of KAI1 and Ki67 expression together may be helpful in evaluating the metastatic potential and prognosis of BTCC patients.展开更多
Building energy consumption accounts for nearly 40% of global energy consumption, HVAC (Heating, Ventilating, and Air Conditioning) systems are the major building energy consumers, and as one type of HVAC systems, t...Building energy consumption accounts for nearly 40% of global energy consumption, HVAC (Heating, Ventilating, and Air Conditioning) systems are the major building energy consumers, and as one type of HVAC systems, the heat pump air conditioning system, which is more energy-efficient compared to the traditional air conditioning system, is being more widely used to save energy. However, in northern China, extreme climatic conditions increase the cooling and heating load of the heat pump air conditioning system and accelerate the aging of the equipment, and the sensor may detect drifted parameters owing to climate change. This non-linear drifted parameter increases the false alarm rate of the fault detection and the need for unnecessary troubleshooting. In order to overcome the impact of the device aging and the drifted parameter, a Kalman filter and SPC (statistical process control) fault detection method are introduced in this paper. In this method, the model parameter and its standard variance can he estimated by Kalman filter based on the gray model and the real-time data of the air conditioning system. Further, by using SPC to construct the dynamic control limits, false alarm rate is reduced. And this paper mainly focuses on the cold machine failure in the component failure and its soft fault detection. This approach has been tested on a simulation model of the "Sino-German Energy Conservation Demonstration Center" building heat pump air-conditioning system in Shenyang, China, and the results show that the Kalman filter and SPC fault detection method is simple and highly efficient with a low false alarm rate, and it can deal with the difficulties caused by the extreme environment and the non-linear influence of the parameters, and what's more, it provides a good foundation for dynamic fault diagnosis and fault prediction analysis.展开更多
Numerical simulation has been carried out to investigate the major factors affecting the time of composite regeneration due to coupling cerium-based additive and microwave for diesel particulate f3ilter(DPF). Effect o...Numerical simulation has been carried out to investigate the major factors affecting the time of composite regeneration due to coupling cerium-based additive and microwave for diesel particulate f3ilter(DPF). Effect on the composite regeneration time from various factors such as mass flow rate of exhaust gas, temperature of exhaust gas, oxygen concentration of exhaust gas, microwave power and amount of cerium-based additive are investigated. And a mathematical model based on fuzzy least squares support vector machines has been developed to forecast the endpoint of the composite regeneration. The results show that the relative error of endpoint forecasting model of composite regeneration is less than 3.5%, and the oxygen concentration of exhaust gas has the biggest effect on the endpoint of composite regeneration, followed by the mass flow rate of exhaust gas, the microwave power, the temperature of exhaust gas and the amount of cerium-based additive.展开更多
文摘本文介绍了GAMBRO AK 200 ULTRA S血透滤过机的工作原理,列举了2例故障案例,其故障提示分别为“UF SELF TEST FAILED,New test within 5 min”及“FLUID TUBES FOR LEAKAGE,Press LOW to confirm”。通过分析可能的故障原因,运用气泡跟踪法及压力变化进行漏气检修,逐步排查,分别采取更换FOVA电磁阀阀膜及清理ZEVA电磁阀阀膜、更换旁路管采样口的措施排除故障。本文通过分析不同的故障类型,介绍不同的漏气检修方法,给维修工程师提供参考,并提示做好预防性维护,定期更换易损件,以此降低故障发生率。
文摘GamBro AK 200 ULTRA S透析机是百特金宝公司生产的双泵透析机,以血液透析滤过功能为特色,兼备血液透析、血液滤过的功能。通常,操作人员在使用过程中的操作失误,会以报警提示的形式呈现,操作人员根据报警提示的引导,即可快速更正操作,报警提示普遍与操作失误相关,然而,也有掩藏在“报警提示”表面下的特殊故障,本文对一例该类特殊故障的检修进行解析。
文摘The face velocities of the high efficiency particulate air filters and the ultra low penetration airfilters in fan filter units (FFUs) have large relative standard deviation and turbulivity. It seriously affects the unidirectivity of the flow in the unidirectional flow clean zone and cleanroom. The cross contamination in this kind of unidirectional flow area is hardly controlled. It is significant to find optional method for keeping the face velocity uniformity of FFU and reducing the face velocity turbulivity of FFU, furthermore, to keep the cleanliness level under FFUs. The normal and easy method is to add flow rectifiers under filters. FFUs with various flow rectifiers have been tested. The uniformity and turbulivity of facevelocity under the FFU are presented in this paper. The influence of the facevelocity uniformity and turbulivity on the contamination boundary of the unidirectional flow is studiedas well.
基金Project 50674093 supported by the National Natural Science Foundation of China
文摘A monitoring system is an important guarantee of safety in a production mine. However, not all monitoring substations pass the electrical fast transient/burst (EFT/B) immunity test and the explosion-proof test simultaneously. To enhance the immunity, the values of capacitance and inductance should be increased, which are actually limited by coal mine explosion-proof standards. Hence, for the first time, an active filter was applied in an electromagnetic interference (EMI) output filter. As a result, the interference within 30 MHz clearly weakened, but the frequency spectrum had a wide range. An EMI input filter and ferrite beads were adopted to restrain higher frequency interference. An output interference spectrogram of the substation was obtained with an analyzer. The results indicate that the improved complex filtering markedly help to control interference. With the support of improved complex filtering and other enhancing immunity means about I/O ports, the substation managed to pass both the EFT/B immunity test and the explosion-proof test synchronously. We conclude that improved complex filtering is of vital importance in enhancing the electromagnetic compatibilitv (EMC) of the coal mine monitoring system.
文摘Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carcinoma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results: In the 62 bladder cancers, the positive rate of PTEN was 53.2% (33/62). All 18 normal bladder tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades (P〈0.05). Conclusion: The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis.
文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage.
基金Supported by the National Nature Science Foundation of China (51174204)
文摘Based on the realization of moving-bed cake filtering, the concepts of static-bed filtering time and moving-bed fil- tering time in the helical-conveyor fine coal filtering centrifuge were proposed, and the mathematic relations between the time defined and the main factors related were studied in detail. The results show that the static-bed filtering time is the function of the spiral heads and the rotation rate deference between the spiral and the porous drum, while the moving-bed filtering time is the function of the cone angle of the porous drum, the radius of the porous drum, the spiral angle, and the rotation rate deference. The functions deduced are of great significance for fine coal filtering centrifuge's parameters determining and optimizing. It is shown that the filtering centrifuge with smaller spiral angle, smaller rotation rate deference, and smaller cone angle may do a better job for fine coal dewatering.
基金Supported by Tianjin Application Basis and Advanced Technology Studied Plans(09JCYBJC08200)
文摘The mechanical dewatering of activated sludge is troublesome due to its high compressibility of solids. The dewatering can be enhanced dramatically by the use of electroosmosis,in which an electric field is applied to the sludge cake.In this study,the influence of filter cloth on the cathode on the dewatering of activated sludge was investigated.It was found that thicker filter cloth led to lower water removal from the sludge cake,so a stainless steel cathode net with small pore size instead of filter cloth was applied,which improves the dewatering efficiency and reduces the electric power consumption.Moreover,water absorbent materials were helpful to remove the water from the sludge cake.For the electroosmotic dewatering at 7 kPa and 24 V·cm-1,the water content in the sludge cake decreased to 60%(by mass) with the average 0.075 kW·h·kg-1of water removed by using the cathode net.
文摘OBJECTIVE To explore the expression and significance of the tumor metastatic suppressor gene the KAI1 and Ki67 antigen in bladder transitional cell carcinoma (BTCC). METHODS Two-stepped immuno-histochemical staining was used to detect the expression of the KAI1 protein and Ki67 antigen. The reverse transcription polymerase chain reaction (RT-PCR) was used to detect the KAI1 mRNA in 54 BTCC specimens and 32 normal bladder counterparts. 13-actin was the internal control. RESULTS The KAI1 protein was mainly expressed on cell membranes at cell-to-cell borders, with uniform and continuous staining in normal bladder transitional epithelium. However, the number of positive-staining cells was greatly decreased in BTCC epithelium, and with an increase in the stage and Grade and appearance of lymph node metastasis the staining was non-uniform and discontinuous. The Ki67 antigen was expressed in the nucleus, and with an increase in the stage and Grade and appearance of lymph node metastasis, the Ki67 expression increased. The Ki67 antigen was negatively related to the expression of KAI1 (P〈0.01).The expression level of KAI1 mRNA was much greater in normal bladder transitional epithelium compared to BTCC, moreover, with an increase in the Grade, infiltration depth and appearance of lymph node metastasis, the expression of KAI1 mRNA was reduced. CONCLUSION The expression of KAI1 protein may be used as a prognostic marker to indicate the degree of infiltration and metastasis. Measurement of KAI1 and Ki67 expression together may be helpful in evaluating the metastatic potential and prognosis of BTCC patients.
基金Supported by the National Natural Science Foundation Committee of China(61503259)China Postdoctoral Science Foundation Funded Project(2017M611261)+1 种基金Chinese Scholarship Council(201608210107)Hanyu Plan of Shenyang Jianzhu University(XKHY2-64)
文摘Building energy consumption accounts for nearly 40% of global energy consumption, HVAC (Heating, Ventilating, and Air Conditioning) systems are the major building energy consumers, and as one type of HVAC systems, the heat pump air conditioning system, which is more energy-efficient compared to the traditional air conditioning system, is being more widely used to save energy. However, in northern China, extreme climatic conditions increase the cooling and heating load of the heat pump air conditioning system and accelerate the aging of the equipment, and the sensor may detect drifted parameters owing to climate change. This non-linear drifted parameter increases the false alarm rate of the fault detection and the need for unnecessary troubleshooting. In order to overcome the impact of the device aging and the drifted parameter, a Kalman filter and SPC (statistical process control) fault detection method are introduced in this paper. In this method, the model parameter and its standard variance can he estimated by Kalman filter based on the gray model and the real-time data of the air conditioning system. Further, by using SPC to construct the dynamic control limits, false alarm rate is reduced. And this paper mainly focuses on the cold machine failure in the component failure and its soft fault detection. This approach has been tested on a simulation model of the "Sino-German Energy Conservation Demonstration Center" building heat pump air-conditioning system in Shenyang, China, and the results show that the Kalman filter and SPC fault detection method is simple and highly efficient with a low false alarm rate, and it can deal with the difficulties caused by the extreme environment and the non-linear influence of the parameters, and what's more, it provides a good foundation for dynamic fault diagnosis and fault prediction analysis.
基金Projects(51176045,51276056)supported by the National Natural Science Foundation of ChinaProject(201208430262)supported by the National Studying Abroad Foundation Project of China
文摘Numerical simulation has been carried out to investigate the major factors affecting the time of composite regeneration due to coupling cerium-based additive and microwave for diesel particulate f3ilter(DPF). Effect on the composite regeneration time from various factors such as mass flow rate of exhaust gas, temperature of exhaust gas, oxygen concentration of exhaust gas, microwave power and amount of cerium-based additive are investigated. And a mathematical model based on fuzzy least squares support vector machines has been developed to forecast the endpoint of the composite regeneration. The results show that the relative error of endpoint forecasting model of composite regeneration is less than 3.5%, and the oxygen concentration of exhaust gas has the biggest effect on the endpoint of composite regeneration, followed by the mass flow rate of exhaust gas, the microwave power, the temperature of exhaust gas and the amount of cerium-based additive.