In order to improve the bias stability of the micro-electro mechanical system(MEMS) gyroscope and reduce the impact on the bias from environmental temperature,a digital signal processing method is described for impr...In order to improve the bias stability of the micro-electro mechanical system(MEMS) gyroscope and reduce the impact on the bias from environmental temperature,a digital signal processing method is described for improving the accuracy of the drive phase in the gyroscope drive mode.Through the principle of bias signal generation,it can be concluded that the deviation of the drive phase is the main factor affecting the bias stability.To fulfill the purpose of precise drive phase control,a digital signal processing circuit based on the field-programmable gate array(FPGA) with the phase-lock closed-loop control method is described and a demodulation method for phase error suppression is given.Compared with the analog circuit,the bias drift is largely reduced in the new digital circuit and the bias stability is improved from 60 to 19 °/h.The new digital control method can greatly increase the drive phase accuracy,and thus improve the bias stability.展开更多
A novel simulation program with an integrated circuit emphasis(SPICE) model developed for trench-gate metal-oxide-semiconductor field-effect transistor(M OSFET)devices is proposed. The drift region resistance was ...A novel simulation program with an integrated circuit emphasis(SPICE) model developed for trench-gate metal-oxide-semiconductor field-effect transistor(M OSFET)devices is proposed. The drift region resistance was modeled according to the physical characteristics and the specific structure of the trench-gate MOSFET device. For the accurate simulation of dynamic characteristics, three important capacitances, gate-to-drain capacitance Cgd, gate-to-source capacitance Cgsand drain-to-source capacitance Cds, were modeled, respectively, in the proposed model. Furthermore,the self-heating effect, temperature effect and breakdown characteristic were taken into account; the self-heating model and breakdown model were built in the proposed model; and the temperature parameters of the model were revised. The proposed model is verified by experimental results, and the errors between measured data and simulation results of the novel model are less than 5%. Therefore, the model can give an accurate description for both the static and dynamic characteristics of the trench-gate MOSFET device.展开更多
A novel floating osmotic pump controlled release system (FOP) and traditional matrix sustained release tablets (MT) of dipyridamole (DIP) were characterized in terms of pharmacokinetics, drug release, and in vit...A novel floating osmotic pump controlled release system (FOP) and traditional matrix sustained release tablets (MT) of dipyridamole (DIP) were characterized in terms of pharmacokinetics, drug release, and in vitro-in vivo correlation. In vivo study was performed by a three-crossover study in six beagle dogs relative to the conventional tablet (CT). A HPLC method for the determination of DIP in the plasma was developed. Cumulative percent of absorption fraction was compared to that of in vitro cumulative release. Both FOP and MT displayed obvious extended release characteristic in vivo while FOP showed a better extended release behavior. The bioavailability of FOP was higher than that of MT and a zero-order release linear correlation of DIP between fraction absorbed in vivo and fraction dissolved in vitro was established for FOP while not for MT. The results indicated the existence of an absorption window in upper part of the GI track of DIP, which meant that floating system could be excellent for the drug delivery. In addition, the in vitro model was a good choice for depicting in vivo absorption and for optimization of the formulation of FOP if it is needed to be bio-equivalent to MT.展开更多
In this paper, we discuss the problem of extreme value for Brownian motion with positive drift. We obtain the joint distribution of the maximum excursion and the minimum excursion.
The mobilities of holes in thin,spin-casting films of poly( N -vinylcarbazole)(PVK) based on silicium are measured using a time-of-flight (TOF) technique.The drift of hole mobility is strongly dependent on the elect...The mobilities of holes in thin,spin-casting films of poly( N -vinylcarbazole)(PVK) based on silicium are measured using a time-of-flight (TOF) technique.The drift of hole mobility is strongly dependent on the electric field and temperature.At room temperature and an electric field of 2×10 5 V·cm -1 ,the effective mobility of hole is 7.14×10 -6 cm 2·V -1 ·s -1 ,in a 200 nm thick sample.展开更多
The remanufacturing system is remolding the manufacturing industry by bringing scrapped products back to such a condition that reintegrated performance is just as good as new.The remanufacturing environment is feature...The remanufacturing system is remolding the manufacturing industry by bringing scrapped products back to such a condition that reintegrated performance is just as good as new.The remanufacturing environment is featured by a far deeper level of uncertainty than new manufacturing,such as probabilistic routing files,and highly variable processing time.The stochastic disturbances result in the production bottlenecks,which constrain the productivity of the job shop.The uncertainties in the remanufacturing process cause the bottlenecks to shift when the workshop is processing.Considering this outstanding problem,many researchers try to optimize the production process to mitigate dynamic bottlenecks toward a balanced state.This paper proposes a data-driven method to predict bottlenecks in the remanufacturing system with multi-variant uncertainties.Firstly,discrete event simulation technology is applied to establish a simulation model of the remanufacturing production line and calculate the bottleneck index to identify bottlenecks.Secondly,a data-driven method,auto-regressive moving average(ARMA)model is employed to predict the bottlenecks in the system based on real-time data captured by the Arena software.Finally,the proposed prediction method is verified on real data from the automobile engine remanufacturing production line.展开更多
Tracking moving target from image or video sequence is a hot research topic in computer vision. An algorithm based on LogGabor wavelet and Mean-shift has been proposed for moving target tracking under fixed camera set...Tracking moving target from image or video sequence is a hot research topic in computer vision. An algorithm based on LogGabor wavelet and Mean-shift has been proposed for moving target tracking under fixed camera setting and complicated environment. Phase coherency of LogGabor wavelet facilitates to extract the edge of moving target and check noise. According to the edge detection,the starting location of Mean-shift can be estimated using the target center coordinate. Eventually,a real-time moving target can be extracted by doing iterative matching pursuit,and experimental results proved the effectiveness of the method proposed.展开更多
To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODSThe thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel diseas...To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODSThe thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy recipients.RESULTSComplete blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the time of sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer (NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells (Tregs) or naïve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iNKT and MAIT cells than healthy controls.CONCLUSIONThiopurine use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients.展开更多
We study the effect of potential and thermal gradient induced non-equilibrium magnetization in quasi1-d itinerant magnets.A semi-phenomenological theory is employed in conjunction with the drift-diffusion model forthi...We study the effect of potential and thermal gradient induced non-equilibrium magnetization in quasi1-d itinerant magnets.A semi-phenomenological theory is employed in conjunction with the drift-diffusion model forthis study.Using the methods of non-equilibrium thermodynamics,we derive the transport currents correspondingto charge,heat,and magnetization flows in the presence of non-equilibrium magnetization textures.It is shown howtime-dependent magnetic textures give rise to charge and thermal currents even in the absence of external potential andthermal gradients through spin pumping.The presence of dynamical textures also affect the thermodynamic parametersof the system.As an application,we consider the case of a helimagnet.展开更多
A key step of constructing active appearance model is requiring a set of appropriate training shapes with well-defined correspondences.In this paper,we introduce a novel point correspondence method(FB-CPD),which can i...A key step of constructing active appearance model is requiring a set of appropriate training shapes with well-defined correspondences.In this paper,we introduce a novel point correspondence method(FB-CPD),which can improve the accuracy of coherent point drift(CPD) by using the information of image feature.The objective function of the proposed method is defined by both of geometric spatial information and image feature information,and the origin Gaussian mixture model in CPD is modified according to the image feature of points.FB-CPD is tested on the 3D prostate and liver point sets through the simulation experiments.The registration error can be reduced efficiently by FB-CPD.Moreover,the active appearance model constructed by FB-CPD can obtain fine segmentation in 3D CT prostate image.Compared with the original CPD,the overlap ratio of voxels was improved from 88.7% to 90.2% by FB-CPD.展开更多
A robust interference canceller for Multi-Carrier Code Division Multiple Access(MC-CDMA) using Orthogonal Frequency Division Multiplexing (OFDM) in Rayleigh fading isproposed. This interference canceller is robust in ...A robust interference canceller for Multi-Carrier Code Division Multiple Access(MC-CDMA) using Orthogonal Frequency Division Multiplexing (OFDM) in Rayleigh fading isproposed. This interference canceller is robust in the sense that it cancels Inter-Carriers Inter-ference (ICI) and is suitable for use in dispersive channels. To come up the effects of the signaldispersion, Doppler shifts and delay spreads on the performance of MC-CDMA systems over mo-bile fading channels, this interference canceller exploits the merit of the orthogonal signaling andpilot signals to evaluate the channel parameters. This interface canceller is well suited to work initerative turbo interference cancellation.展开更多
基金The National Natural Science Foundation of China (No.60974116)the Research Fund of Aeronautics Science (No. 20090869007)Specialized Research Fund for the Doctoral Program of Higher Education(No. 200802861063)
文摘In order to improve the bias stability of the micro-electro mechanical system(MEMS) gyroscope and reduce the impact on the bias from environmental temperature,a digital signal processing method is described for improving the accuracy of the drive phase in the gyroscope drive mode.Through the principle of bias signal generation,it can be concluded that the deviation of the drive phase is the main factor affecting the bias stability.To fulfill the purpose of precise drive phase control,a digital signal processing circuit based on the field-programmable gate array(FPGA) with the phase-lock closed-loop control method is described and a demodulation method for phase error suppression is given.Compared with the analog circuit,the bias drift is largely reduced in the new digital circuit and the bias stability is improved from 60 to 19 °/h.The new digital control method can greatly increase the drive phase accuracy,and thus improve the bias stability.
基金The National Natural Science Foundation of China(No.61604038)China Postdoctoral Science Foundation(No.2015M580376)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20160691)Jiangsu Postdoctoral Science Foundation(No.1501010A)
文摘A novel simulation program with an integrated circuit emphasis(SPICE) model developed for trench-gate metal-oxide-semiconductor field-effect transistor(M OSFET)devices is proposed. The drift region resistance was modeled according to the physical characteristics and the specific structure of the trench-gate MOSFET device. For the accurate simulation of dynamic characteristics, three important capacitances, gate-to-drain capacitance Cgd, gate-to-source capacitance Cgsand drain-to-source capacitance Cds, were modeled, respectively, in the proposed model. Furthermore,the self-heating effect, temperature effect and breakdown characteristic were taken into account; the self-heating model and breakdown model were built in the proposed model; and the temperature parameters of the model were revised. The proposed model is verified by experimental results, and the errors between measured data and simulation results of the novel model are less than 5%. Therefore, the model can give an accurate description for both the static and dynamic characteristics of the trench-gate MOSFET device.
文摘A novel floating osmotic pump controlled release system (FOP) and traditional matrix sustained release tablets (MT) of dipyridamole (DIP) were characterized in terms of pharmacokinetics, drug release, and in vitro-in vivo correlation. In vivo study was performed by a three-crossover study in six beagle dogs relative to the conventional tablet (CT). A HPLC method for the determination of DIP in the plasma was developed. Cumulative percent of absorption fraction was compared to that of in vitro cumulative release. Both FOP and MT displayed obvious extended release characteristic in vivo while FOP showed a better extended release behavior. The bioavailability of FOP was higher than that of MT and a zero-order release linear correlation of DIP between fraction absorbed in vivo and fraction dissolved in vitro was established for FOP while not for MT. The results indicated the existence of an absorption window in upper part of the GI track of DIP, which meant that floating system could be excellent for the drug delivery. In addition, the in vitro model was a good choice for depicting in vivo absorption and for optimization of the formulation of FOP if it is needed to be bio-equivalent to MT.
基金Supported by the National Natural Foundation of China(10271062,10411076)Supported by the Research Fund for the Doctorial Program of Qufu Normal University(20050701)
文摘In this paper, we discuss the problem of extreme value for Brownian motion with positive drift. We obtain the joint distribution of the maximum excursion and the minimum excursion.
文摘The mobilities of holes in thin,spin-casting films of poly( N -vinylcarbazole)(PVK) based on silicium are measured using a time-of-flight (TOF) technique.The drift of hole mobility is strongly dependent on the electric field and temperature.At room temperature and an electric field of 2×10 5 V·cm -1 ,the effective mobility of hole is 7.14×10 -6 cm 2·V -1 ·s -1 ,in a 200 nm thick sample.
基金Projects(51975099,51775086)supported by the Natural Science Foundation of China。
文摘The remanufacturing system is remolding the manufacturing industry by bringing scrapped products back to such a condition that reintegrated performance is just as good as new.The remanufacturing environment is featured by a far deeper level of uncertainty than new manufacturing,such as probabilistic routing files,and highly variable processing time.The stochastic disturbances result in the production bottlenecks,which constrain the productivity of the job shop.The uncertainties in the remanufacturing process cause the bottlenecks to shift when the workshop is processing.Considering this outstanding problem,many researchers try to optimize the production process to mitigate dynamic bottlenecks toward a balanced state.This paper proposes a data-driven method to predict bottlenecks in the remanufacturing system with multi-variant uncertainties.Firstly,discrete event simulation technology is applied to establish a simulation model of the remanufacturing production line and calculate the bottleneck index to identify bottlenecks.Secondly,a data-driven method,auto-regressive moving average(ARMA)model is employed to predict the bottlenecks in the system based on real-time data captured by the Arena software.Finally,the proposed prediction method is verified on real data from the automobile engine remanufacturing production line.
文摘Tracking moving target from image or video sequence is a hot research topic in computer vision. An algorithm based on LogGabor wavelet and Mean-shift has been proposed for moving target tracking under fixed camera setting and complicated environment. Phase coherency of LogGabor wavelet facilitates to extract the edge of moving target and check noise. According to the edge detection,the starting location of Mean-shift can be estimated using the target center coordinate. Eventually,a real-time moving target can be extracted by doing iterative matching pursuit,and experimental results proved the effectiveness of the method proposed.
基金Supported by Virginia Mason Medical Center,Digestive Disease Institute Research Grant Award,No.0506812-2011
文摘To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODSThe thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy recipients.RESULTSComplete blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the time of sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer (NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells (Tregs) or naïve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iNKT and MAIT cells than healthy controls.CONCLUSIONThiopurine use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients.
文摘We study the effect of potential and thermal gradient induced non-equilibrium magnetization in quasi1-d itinerant magnets.A semi-phenomenological theory is employed in conjunction with the drift-diffusion model forthis study.Using the methods of non-equilibrium thermodynamics,we derive the transport currents correspondingto charge,heat,and magnetization flows in the presence of non-equilibrium magnetization textures.It is shown howtime-dependent magnetic textures give rise to charge and thermal currents even in the absence of external potential andthermal gradients through spin pumping.The presence of dynamical textures also affect the thermodynamic parametersof the system.As an application,we consider the case of a helimagnet.
基金National Basic Research Program of China(973 Program)grant number:2010CB732505+1 种基金National Natural Science Foundation of Chinagrant number:30900380
文摘A key step of constructing active appearance model is requiring a set of appropriate training shapes with well-defined correspondences.In this paper,we introduce a novel point correspondence method(FB-CPD),which can improve the accuracy of coherent point drift(CPD) by using the information of image feature.The objective function of the proposed method is defined by both of geometric spatial information and image feature information,and the origin Gaussian mixture model in CPD is modified according to the image feature of points.FB-CPD is tested on the 3D prostate and liver point sets through the simulation experiments.The registration error can be reduced efficiently by FB-CPD.Moreover,the active appearance model constructed by FB-CPD can obtain fine segmentation in 3D CT prostate image.Compared with the original CPD,the overlap ratio of voxels was improved from 88.7% to 90.2% by FB-CPD.
基金the National Natural Science Foundation of China(No.60172048)
文摘A robust interference canceller for Multi-Carrier Code Division Multiple Access(MC-CDMA) using Orthogonal Frequency Division Multiplexing (OFDM) in Rayleigh fading isproposed. This interference canceller is robust in the sense that it cancels Inter-Carriers Inter-ference (ICI) and is suitable for use in dispersive channels. To come up the effects of the signaldispersion, Doppler shifts and delay spreads on the performance of MC-CDMA systems over mo-bile fading channels, this interference canceller exploits the merit of the orthogonal signaling andpilot signals to evaluate the channel parameters. This interface canceller is well suited to work initerative turbo interference cancellation.