With the widespread application and fast development of gas and oil pipeline network in China, the pipeline inspection technology has been used more extensively. The magnetic flux leakage (MFL) method has establishe...With the widespread application and fast development of gas and oil pipeline network in China, the pipeline inspection technology has been used more extensively. The magnetic flux leakage (MFL) method has established itself as the most widely used in-line inspection technique for the evaluation of gas and oil pipelines. The MFL data obtained from seamless pipeline inspection is usually contaminated by the seamless pipe noise (SPN). SPN can in some cases completely mask MFL signals from certain type of defects, and therefore considerably reduces the detectability of the defect signals. In this paper, a new de-noising algorithm called wavelet domain adaptive filtering is proposed for removing the SPN contained in the MFL data. The new algorithm results from combining the wavelet transform with the adaptive filtering technique. Results from application of the proposed algorithm to the MFL data from field tests show that the proposed algorithm has good performance and considerably improves the detectability of the defect signals in the MFL data.展开更多
In this paper,we propose a hybrid power model that includes the power consumption of not only the registers but also part of the combinational logic.By doing knownkey analysis with this hybrid model,power side-channel...In this paper,we propose a hybrid power model that includes the power consumption of not only the registers but also part of the combinational logic.By doing knownkey analysis with this hybrid model,power side-channel leakage caused by correct keys can be detected.In experiment,PRINTcipher and DES algorithms were chosen as analysis targets and combinational logic s-box unit was selected to build power template.The analysis results showed the signal-to-noise ratio(SNR) power consumption increase of more than 20%after considering s-box's power consumption so that the information of keys can be obtained with just half number of power traces.In addition,the side channel-leakage detection capability of our method also shows better effectiveness that can identify the correct keys.展开更多
Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive ...Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline,an idea that underlies the'amyloid hypothesis'of AD etiology in both the familal(FAD) and sporadic forms of the disease.Genetic mutations causing FAD also result in the dysregulation of neuronal calcium(Ca2+) handling and may contribute to AD pathogenesis,an idea termed the'calcium hypothesis'of AD.Mutations in presenilin proteins account for majority of FAD cases.Presenilins function as catalytic subunit ofγ-secretase involved in generation of Aβ peptide Recently,we discovered that presenilns function as low-conductance,passive ER Ca2+ leak channels,independent of γ-secretase activity.We further discovered that many FAD mutations in presenilins result in loss of ER Ca2+ leak function activity and Ca2+ overload in the ER.These results provided potential explanation for abnormal Ca2+ signaling observed in FAD cells with mutations in presenilns.Our latest work on studies of ER Ca2+ leak channel function of presenilins and implications of these findings for understanding AD pathogenesis are discussed in this article.展开更多
The near casing flow fields inside the rotor passage of a 1.5 stage axial compressor with different blade-loading levels and tip gap sizes were measured by using stereoscopic particle image velocimetry(SPIV). Based on...The near casing flow fields inside the rotor passage of a 1.5 stage axial compressor with different blade-loading levels and tip gap sizes were measured by using stereoscopic particle image velocimetry(SPIV). Based on a carefully defined blockage extracting method, the variations of blockage parameter inside the blade passage were analyzed. It was found that the variation of blockage parameter appeared as a non-monotonic behavior inside the blade passage in most cases. This non-monotonic behavior became much more remarkable as the blade loading increases or mass flow rate decreases.The variations of the blockage parameter inside the blade passage had close relation to the evolutionary procedures of the tip leakage vortex(TLV). The destabilization of the TLV caused a rapid increasing of the blockage parameter. After the TLV lost the features of a concentrated streamwise vortex,the blockage parameter usually got a peak value. And then, because of the intense turbulent mixing between the TLV low momentum flow and its surrounding flows, the flow deficit inside the TLV recovered.展开更多
To get an insight into the occurrence and the mechanism of flow unsteadiness in the tip region of centrifugal compressor impellers, the flow in Krain’s impeller is investigated by using both steady and unsteady RAN...To get an insight into the occurrence and the mechanism of flow unsteadiness in the tip region of centrifugal compressor impellers, the flow in Krain’s impeller is investigated by using both steady and unsteady RANS solver techniques. It is found that the flow unsteadiness on the pressure side is much stronger than that on the suction side. The periodical frequency of the unsteady flow is around half of the blade passing frequency. The originating mechanism of the flow unsteadiness is illustrated with the time-dependent tip leakage flow and blade loading at the tip region. Due to the blockage caused by the joint effects of broken-downed tip leakage vortex, separated fluids and tip leakage flow at downstream, a low pressure region is formed on the pressure side, consequently the blade loadings is altered. In turn, the changed blade loadings will alter the intensity of tip leakage flow. Such alternative behavior finally results in the periodic process. By comparing the calculated flow field in the cases of single-passage and four-passage models, it is confirmed that the investigated flow unsteadiness is confined in each single passage, as no phase differences are found in the model of four passages. This is different from the situation in axial compressor when the rotating instability is encountered. The flow unsteadiness only occurs at the working conditions with small mass flow rates, and the oscillation intensity will be enhanced with the decrease of mass flow rate. When the mass flow rate is too small, the flow unsteadiness in a single passage may trigger rotating stall, as the disturbance propagates in the circumferential direction.展开更多
文摘With the widespread application and fast development of gas and oil pipeline network in China, the pipeline inspection technology has been used more extensively. The magnetic flux leakage (MFL) method has established itself as the most widely used in-line inspection technique for the evaluation of gas and oil pipelines. The MFL data obtained from seamless pipeline inspection is usually contaminated by the seamless pipe noise (SPN). SPN can in some cases completely mask MFL signals from certain type of defects, and therefore considerably reduces the detectability of the defect signals. In this paper, a new de-noising algorithm called wavelet domain adaptive filtering is proposed for removing the SPN contained in the MFL data. The new algorithm results from combining the wavelet transform with the adaptive filtering technique. Results from application of the proposed algorithm to the MFL data from field tests show that the proposed algorithm has good performance and considerably improves the detectability of the defect signals in the MFL data.
基金supported by Major State Basic Research Development Program(No. 2013CB338004)National Natural Science Foundation of China(No.61402286, 61472250,61472249,61202372)+1 种基金National Science and Technology Major Project of the Ministry of Science and Technology of China (No.2014ZX01032401-001)Plan of Action for the Innovation of Science and Technology of Shanghai Municipal Science and Technology Commission(No.14511100300)
文摘In this paper,we propose a hybrid power model that includes the power consumption of not only the registers but also part of the combinational logic.By doing knownkey analysis with this hybrid model,power side-channel leakage caused by correct keys can be detected.In experiment,PRINTcipher and DES algorithms were chosen as analysis targets and combinational logic s-box unit was selected to build power template.The analysis results showed the signal-to-noise ratio(SNR) power consumption increase of more than 20%after considering s-box's power consumption so that the information of keys can be obtained with just half number of power traces.In addition,the side channel-leakage detection capability of our method also shows better effectiveness that can identify the correct keys.
基金supported by the McKnight Neuroscience of Brain Disorders Award and NIH grant R01AG030746
文摘Alzheimer disease(AD) is the most common neurodegenerative disorder worldwide and is at present,incurable.The accumulation of toxic amyloid-beta(Aβ) peptide aggregates in AD brain is thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline,an idea that underlies the'amyloid hypothesis'of AD etiology in both the familal(FAD) and sporadic forms of the disease.Genetic mutations causing FAD also result in the dysregulation of neuronal calcium(Ca2+) handling and may contribute to AD pathogenesis,an idea termed the'calcium hypothesis'of AD.Mutations in presenilin proteins account for majority of FAD cases.Presenilins function as catalytic subunit ofγ-secretase involved in generation of Aβ peptide Recently,we discovered that presenilns function as low-conductance,passive ER Ca2+ leak channels,independent of γ-secretase activity.We further discovered that many FAD mutations in presenilins result in loss of ER Ca2+ leak function activity and Ca2+ overload in the ER.These results provided potential explanation for abnormal Ca2+ signaling observed in FAD cells with mutations in presenilns.Our latest work on studies of ER Ca2+ leak channel function of presenilins and implications of these findings for understanding AD pathogenesis are discussed in this article.
基金funded by the National Natural Science Foundation of China,Grant No.51006007,51136003 and 50976009
文摘The near casing flow fields inside the rotor passage of a 1.5 stage axial compressor with different blade-loading levels and tip gap sizes were measured by using stereoscopic particle image velocimetry(SPIV). Based on a carefully defined blockage extracting method, the variations of blockage parameter inside the blade passage were analyzed. It was found that the variation of blockage parameter appeared as a non-monotonic behavior inside the blade passage in most cases. This non-monotonic behavior became much more remarkable as the blade loading increases or mass flow rate decreases.The variations of the blockage parameter inside the blade passage had close relation to the evolutionary procedures of the tip leakage vortex(TLV). The destabilization of the TLV caused a rapid increasing of the blockage parameter. After the TLV lost the features of a concentrated streamwise vortex,the blockage parameter usually got a peak value. And then, because of the intense turbulent mixing between the TLV low momentum flow and its surrounding flows, the flow deficit inside the TLV recovered.
基金supported by the National Natural Science Foundation of China (Grant Nos. 51236006, 51576153)
文摘To get an insight into the occurrence and the mechanism of flow unsteadiness in the tip region of centrifugal compressor impellers, the flow in Krain’s impeller is investigated by using both steady and unsteady RANS solver techniques. It is found that the flow unsteadiness on the pressure side is much stronger than that on the suction side. The periodical frequency of the unsteady flow is around half of the blade passing frequency. The originating mechanism of the flow unsteadiness is illustrated with the time-dependent tip leakage flow and blade loading at the tip region. Due to the blockage caused by the joint effects of broken-downed tip leakage vortex, separated fluids and tip leakage flow at downstream, a low pressure region is formed on the pressure side, consequently the blade loadings is altered. In turn, the changed blade loadings will alter the intensity of tip leakage flow. Such alternative behavior finally results in the periodic process. By comparing the calculated flow field in the cases of single-passage and four-passage models, it is confirmed that the investigated flow unsteadiness is confined in each single passage, as no phase differences are found in the model of four passages. This is different from the situation in axial compressor when the rotating instability is encountered. The flow unsteadiness only occurs at the working conditions with small mass flow rates, and the oscillation intensity will be enhanced with the decrease of mass flow rate. When the mass flow rate is too small, the flow unsteadiness in a single passage may trigger rotating stall, as the disturbance propagates in the circumferential direction.