Kaposi's sarcoma-associated herpesvirus(KSHV) is a double stranded DNA virus.It was found to be related to Kaposi's sarcoma(KS),primary effusion lymphoma(PEL) and multicentric Castleman's disease(MCD),whic...Kaposi's sarcoma-associated herpesvirus(KSHV) is a double stranded DNA virus.It was found to be related to Kaposi's sarcoma(KS),primary effusion lymphoma(PEL) and multicentric Castleman's disease(MCD),which cause severe illness in AIDS patients.As a member of human herpesvirus family,KSHV displays two distinct phases in its life cycle,the default latent and lytic replication phase.Following primary infection,the virus can quickly establish latent infection in the host.However,it is still not fully understood up to date how KSHV establishes and maintains viral latency in the host cells.KSHV mainly infects endothelial cells in the host,promoting proliferation and angiogenesis.Abundant angiogenesis is the key feature of KS and is the critical factor for KS progression.The mechanism of KSHV mediated pathogenesis is also largely unknown.In this review,we summarize the recent progress in the mechanisms of KSHV latency and pathogenesis,with particular views from our work.展开更多
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.81425017)the Key Project of National Natural Science Foundation of China(Grant No.81230037)+2 种基金the National Basic Research Program of China(Grant No.2011CB504800)supported by the National Natural Science Foundation of China(Grant No.81201279)CAS Youth Innovation Promotion Association
文摘Kaposi's sarcoma-associated herpesvirus(KSHV) is a double stranded DNA virus.It was found to be related to Kaposi's sarcoma(KS),primary effusion lymphoma(PEL) and multicentric Castleman's disease(MCD),which cause severe illness in AIDS patients.As a member of human herpesvirus family,KSHV displays two distinct phases in its life cycle,the default latent and lytic replication phase.Following primary infection,the virus can quickly establish latent infection in the host.However,it is still not fully understood up to date how KSHV establishes and maintains viral latency in the host cells.KSHV mainly infects endothelial cells in the host,promoting proliferation and angiogenesis.Abundant angiogenesis is the key feature of KS and is the critical factor for KS progression.The mechanism of KSHV mediated pathogenesis is also largely unknown.In this review,we summarize the recent progress in the mechanisms of KSHV latency and pathogenesis,with particular views from our work.
