Frailty is a state of late life decline and vulnerability, typified by physical weakness and decreased physiologic reserve. The epidemiology and pathophysiology of frailty share features with those of cardiovascular d...Frailty is a state of late life decline and vulnerability, typified by physical weakness and decreased physiologic reserve. The epidemiology and pathophysiology of frailty share features with those of cardiovascular disease. Gait speed can be used as a measure of frailty and is a powerful predictor of mortality. Advancing age is a potent risk factor for cardiovascular disease and has been associated with an increased risk of adverse outcomes. Older adults comprise approximately half of cardiac surgery patients, and account for nearly 80% of the major complications and deaths following surgery. The ability of traditional risk models to predict mortality and major morbidity in older patients being considered for cardiac surgery may improve if frailty, as measured by gait speed, is included in their assessment. It is possible that in the future frailty assessment may assist in choosing among therapies （e.g., surgical vs. percutaneous aortic valve replacement for patients with aortic stenosis）.展开更多
In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(...In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(Tolerable Average Use Delay)is defined,it quantifies the performance of an adaptation scheme in tolerating the delay of channel estimates.Then,the research on TAUD shows that the delay tolerating performance declines with the increase in average power,the scheme working with more modulation modes can tolerate a longer delay,and such improvement will be more significant with the increase of average power.Finally,it shows that,as the delay tolerating performance determines the maximum block length,it has a great effect on the maximum spectral efficiency.The criterion for determining the block length appropriate for the target BER is described and a simple method of calculating the maximum block length is presented.展开更多
Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulat...Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.展开更多
In this paper,we derive an estimate on the potential functions of complete noncompact gradient shrinking solitons of Ricci-harmonic flow,and show that complete noncompact gradient shrinking Ricci-harmonic solitons hav...In this paper,we derive an estimate on the potential functions of complete noncompact gradient shrinking solitons of Ricci-harmonic flow,and show that complete noncompact gradient shrinking Ricci-harmonic solitons have Euclidean volume growth at most.展开更多
The authors prove that the total descendant potential functions of the theory of Fan-Jarvis-Ruan-Witten for D4 with symmetry group J and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4...The authors prove that the total descendant potential functions of the theory of Fan-Jarvis-Ruan-Witten for D4 with symmetry group J and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4 Kac-Wakimoto/Drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-Jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（ADE） singularities.展开更多
The integrable nonlocal Lakshmanan–Porsezian–Daniel(LPD) equation which has the higher-order terms(dispersions and nonlinear effects) is first introduced. We demonstrate the integrability of the nonlocal LPD equatio...The integrable nonlocal Lakshmanan–Porsezian–Daniel(LPD) equation which has the higher-order terms(dispersions and nonlinear effects) is first introduced. We demonstrate the integrability of the nonlocal LPD equation,provide its Lax pair, and present its rational soliton solutions and self-potential function by using the degenerate Darboux transformation. From the numerical plots of solutions, the compression effects of the real refractive index profile and the gain-or-loss distribution produced by δ are discussed.展开更多
A vector space structure is proposed for the set of finite games with fixed nmnbers of players and strategies for each players. Two statical equivalences are used to reduce tile dimension of finite games. Under the ve...A vector space structure is proposed for the set of finite games with fixed nmnbers of players and strategies for each players. Two statical equivalences are used to reduce tile dimension of finite games. Under the vector space structure the subspaces of exact and weighted potential games are investigated. Formulas are provided to calculate them. Then the finite evolutionary games （EGs） are considered. Strategy profile dynamics is obtained using different strategy updating rules （SURs）. Certain SURs, which assure the convergence of trajectories to pure Nash equilibriums, are investigated. Using the vector space structure, the projection of finite games to the subspace of exact （or weighted） potential games is considered, and a simple formula is given to calculate the projection. The convergence of near potential games to an c-equilibrium is studied. Further more, the Lyapunov function of EGs is defined and its application to the convergence of EGs is presented. Finally, the near potential function for an EG is defined, and it is proved that if the near potential function of an EG is a Lyapunov function, the EG will converge to a pure Nash equilibrium. Some examples are presented to illustrate the results.展开更多
The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry...The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC.In recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions.Here,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.展开更多
文摘Frailty is a state of late life decline and vulnerability, typified by physical weakness and decreased physiologic reserve. The epidemiology and pathophysiology of frailty share features with those of cardiovascular disease. Gait speed can be used as a measure of frailty and is a powerful predictor of mortality. Advancing age is a potent risk factor for cardiovascular disease and has been associated with an increased risk of adverse outcomes. Older adults comprise approximately half of cardiac surgery patients, and account for nearly 80% of the major complications and deaths following surgery. The ability of traditional risk models to predict mortality and major morbidity in older patients being considered for cardiac surgery may improve if frailty, as measured by gait speed, is included in their assessment. It is possible that in the future frailty assessment may assist in choosing among therapies （e.g., surgical vs. percutaneous aortic valve replacement for patients with aortic stenosis）.
基金supported by National Natural Science Foundation of China(No.61071087)Chun Lei 2009BWZ037 from SDUST,China
文摘In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(Tolerable Average Use Delay)is defined,it quantifies the performance of an adaptation scheme in tolerating the delay of channel estimates.Then,the research on TAUD shows that the delay tolerating performance declines with the increase in average power,the scheme working with more modulation modes can tolerate a longer delay,and such improvement will be more significant with the increase of average power.Finally,it shows that,as the delay tolerating performance determines the maximum block length,it has a great effect on the maximum spectral efficiency.The criterion for determining the block length appropriate for the target BER is described and a simple method of calculating the maximum block length is presented.
文摘Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No. 2011JC021)
文摘In this paper,we derive an estimate on the potential functions of complete noncompact gradient shrinking solitons of Ricci-harmonic flow,and show that complete noncompact gradient shrinking Ricci-harmonic solitons have Euclidean volume growth at most.
基金supported by the National Natural Science Foundation of China(Nos.1132510111271028)+1 种基金the National Security Agency of USA(No.H98230-10-1-0181)the Doctoral Fund of the Ministry of Education of China(No.20120001110060)
文摘The authors prove that the total descendant potential functions of the theory of Fan-Jarvis-Ruan-Witten for D4 with symmetry group J and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4 Kac-Wakimoto/Drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-Jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（ADE） singularities.
基金Supported by the National Natural Science Foundation of China under Grant No.11271210the K.C.Wong Magna Fund in Ningbo University
文摘The integrable nonlocal Lakshmanan–Porsezian–Daniel(LPD) equation which has the higher-order terms(dispersions and nonlinear effects) is first introduced. We demonstrate the integrability of the nonlocal LPD equation,provide its Lax pair, and present its rational soliton solutions and self-potential function by using the degenerate Darboux transformation. From the numerical plots of solutions, the compression effects of the real refractive index profile and the gain-or-loss distribution produced by δ are discussed.
基金supported partly by the National Natural Science Foundation of China under Grant Nos.61273013,61333001,61104065,and 61374168
文摘A vector space structure is proposed for the set of finite games with fixed nmnbers of players and strategies for each players. Two statical equivalences are used to reduce tile dimension of finite games. Under the vector space structure the subspaces of exact and weighted potential games are investigated. Formulas are provided to calculate them. Then the finite evolutionary games （EGs） are considered. Strategy profile dynamics is obtained using different strategy updating rules （SURs）. Certain SURs, which assure the convergence of trajectories to pure Nash equilibriums, are investigated. Using the vector space structure, the projection of finite games to the subspace of exact （or weighted） potential games is considered, and a simple formula is given to calculate the projection. The convergence of near potential games to an c-equilibrium is studied. Further more, the Lyapunov function of EGs is defined and its application to the convergence of EGs is presented. Finally, the near potential function for an EG is defined, and it is proved that if the near potential function of an EG is a Lyapunov function, the EG will converge to a pure Nash equilibrium. Some examples are presented to illustrate the results.
基金supported by the National Institutes of Health(Grant No. 5R01HL097111)to Mohamed Trebak
文摘The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC.In recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions.Here,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.
