Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulat...Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.展开更多
A harmonic vortex beam is a typical vector beam with a helical wavefront at harmonic frequencies(e.g.,second and third harmonics). It provides an additional degree of freedom beyond spin-and orbitalangular momentum, w...A harmonic vortex beam is a typical vector beam with a helical wavefront at harmonic frequencies(e.g.,second and third harmonics). It provides an additional degree of freedom beyond spin-and orbitalangular momentum, which may greatly increase the capacity for communicating and encoding information. However, conventional harmonic vortex beam generators suffer from complex designs and a low nonlinear conversion efficiency. Here, we propose and experimentally demonstrate the generation of a large second-harmonic(SH) vortex beam with quasi-nonlinear spin–orbit interaction(SOI). Highquality SH vortex beams with large topological charges up to 28 are realized experimentally. This indicated that the quasi-angular-momentum of a plasmonic spiral phase plate at the excitation wavelength(topological charge, q) could be imprinted on the harmonic signals from the attached WS2 monolayer. The generated harmonic vortex beam has a topological charge of l_(n)= 2 nq(n is the harmonic order). The results may open new avenues for generating harmonic optical vortices for optical communications and enables novel multi-functional hybrid metasurface devices to manipulate harmonic beams.展开更多
文摘Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differ- entiation, survival, and adhesion, β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
基金This work was supported by the National Natural Science Foundation of China(91850113,11774115 and 11904271)the National Basic Research Program of China(2014CB921301)the Basic and Applied Basic Research Major Program of Guangdong Province(2019B030302003)。
文摘A harmonic vortex beam is a typical vector beam with a helical wavefront at harmonic frequencies(e.g.,second and third harmonics). It provides an additional degree of freedom beyond spin-and orbitalangular momentum, which may greatly increase the capacity for communicating and encoding information. However, conventional harmonic vortex beam generators suffer from complex designs and a low nonlinear conversion efficiency. Here, we propose and experimentally demonstrate the generation of a large second-harmonic(SH) vortex beam with quasi-nonlinear spin–orbit interaction(SOI). Highquality SH vortex beams with large topological charges up to 28 are realized experimentally. This indicated that the quasi-angular-momentum of a plasmonic spiral phase plate at the excitation wavelength(topological charge, q) could be imprinted on the harmonic signals from the attached WS2 monolayer. The generated harmonic vortex beam has a topological charge of l_(n)= 2 nq(n is the harmonic order). The results may open new avenues for generating harmonic optical vortices for optical communications and enables novel multi-functional hybrid metasurface devices to manipulate harmonic beams.
