[目的]探讨血清磷脂酶A2组ⅡA (phospholipase A2 groupⅡA,PLA2G2A)和凝血因子Ⅸ(coagulation factorⅨ,F9)对耐多药肺结核病(multidrug-resistant tuberculosis,MDR-TB)气阴两虚(deficiency of Qi and Yin,DQY)证的潜在诊断价值。[方...[目的]探讨血清磷脂酶A2组ⅡA (phospholipase A2 groupⅡA,PLA2G2A)和凝血因子Ⅸ(coagulation factorⅨ,F9)对耐多药肺结核病(multidrug-resistant tuberculosis,MDR-TB)气阴两虚(deficiency of Qi and Yin,DQY)证的潜在诊断价值。[方法]选择MDR-TB肺阴虚(pulmonary Yin deficiency,PYD)证、MDR-TB阴虚火旺(hyperactivity of fire due to Yin deficiency,HFYD)证、MDR-TB DQY证患者和健康对照(healthy control,HC)者各15例,以ELISA检测每组PLA2G2A和F9的蛋白浓度,并利用受试者工作特征(receiver operating characteristic, ROC)曲线分析PLA2G2A和F9作为MDR-TB DQY证潜在生物学标志物的临床价值。[结果]MDR-TB证候分布以DQY证患者数最多,其次是HFYD证,再者是DQY证,而阴阳两虚(deficiency of Yin and Yang, DYY)证患者数最少。DQY证组PLA2G2A的蛋白浓度均明显高于PYD证组、HFYD证组和HC组,差异有统计学意义(P<0.05);DQY证组F9的蛋白浓度明显低于HFYD证组,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清PLA2G2A有鉴别诊断MDR-TB DQY证的作用。[结论]血清PLA2G2A和F9在诊断MDR-TB DQY证方面具备一定临床价值,血清PLA2G2A可作为MDR-TB DQY证的潜在生物学标志物。展开更多
文摘[目的]探讨血清磷脂酶A2组ⅡA (phospholipase A2 groupⅡA,PLA2G2A)和凝血因子Ⅸ(coagulation factorⅨ,F9)对耐多药肺结核病(multidrug-resistant tuberculosis,MDR-TB)气阴两虚(deficiency of Qi and Yin,DQY)证的潜在诊断价值。[方法]选择MDR-TB肺阴虚(pulmonary Yin deficiency,PYD)证、MDR-TB阴虚火旺(hyperactivity of fire due to Yin deficiency,HFYD)证、MDR-TB DQY证患者和健康对照(healthy control,HC)者各15例,以ELISA检测每组PLA2G2A和F9的蛋白浓度,并利用受试者工作特征(receiver operating characteristic, ROC)曲线分析PLA2G2A和F9作为MDR-TB DQY证潜在生物学标志物的临床价值。[结果]MDR-TB证候分布以DQY证患者数最多,其次是HFYD证,再者是DQY证,而阴阳两虚(deficiency of Yin and Yang, DYY)证患者数最少。DQY证组PLA2G2A的蛋白浓度均明显高于PYD证组、HFYD证组和HC组,差异有统计学意义(P<0.05);DQY证组F9的蛋白浓度明显低于HFYD证组,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清PLA2G2A有鉴别诊断MDR-TB DQY证的作用。[结论]血清PLA2G2A和F9在诊断MDR-TB DQY证方面具备一定临床价值,血清PLA2G2A可作为MDR-TB DQY证的潜在生物学标志物。
