Objective: Optimization of combining electroencephalography (EEG), short latency somatosensory evoked potentials (SLSEP) and transcranial Doppler (TCD) techniques to diagnose brain death. Methods: One hundred and elev...Objective: Optimization of combining electroencephalography (EEG), short latency somatosensory evoked potentials (SLSEP) and transcranial Doppler (TCD) techniques to diagnose brain death. Methods: One hundred and eleven patients (69 males, 42 females) from the major hospitals of Zhejiang Province were examined with portable EEG, SLSEP and TCD devices. Re-examinations occurred ≤12 h later. Results: The first examination revealed that the combination of SLSEP and EEG led to more sensitive diagnoses than the combination of SLSEP and TCD. Re-examination confirmed this and also revealed that the combination of TCD and EEG was the most sensitive. Conclusion: The results show that using multiple techniques to diagnose brain death is superior to using single method, and that the combination of SLSEP and EEG is better than other combinations.展开更多
AIM: To study the toxicity of bicyclol to animals. METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats ...AIM: To study the toxicity of bicyclol to animals. METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats were orally administered bicyclol at a dose of 5 g/kg body weight. Death and clinical symptoms of animals were recorded within 7 d. Sub-acute toxicity test was carried out in rats that were treated with various doses of bicyclol (150, 300, 600 mg/kg) once daily for 14 d. Animal behaviors, blood biochemical markers, blood and urine pictures were examined. Chronic toxicity test was conducted in 80 Wistar rats of both sexes. The animals were orally administered with various doses of bicyclol [150, 300, 600 mg/kg, 100-400 folds corresponding to the proposed therapeutic dose (1.5 mg/(kg·d)) of bicyclol for patients] once daily for 6 mo except for Sunday. The control group was given the same volume of 0.2% sodium carboxyl methylcellulose (Na-CMC). Twenty-one beagle dogs received bicyclol (25, 75, 225 mg/kg, 16.6, 50, 150 folds corresponding to the proposed therapeutic dose of bicyclol for patients) once a day for 6 mo except for Sunday. The body weight, food intake, urine and feces, blood picture, blood biochemical markers, and pathological examination of main organs were determined. Mutagenicity and teratogenicity were determined. Mutagenicity assay included Ames's test, chromosome aberration test in CHL cells and micronucleus test in mice. For the teratogenicity assay, pregnant Wistar rats weighing 200-250 g were treated with 0.2,1.0 g/kg bicyclol once daily from the 7th d of gestation for 10 d. RESULTS: The oral LD50 of bicyclol was over 5 g/kg in mice and rats. No noticeable alterations in subacute and chronic toxicity of rats and dogs were demonstrated. No mutagenicity and teratogenicity of bicyclol were found. CONCLUSION: Bicyclol has no detectable chronic toxicity as well as mutagenicity and teratogenicity in animals.展开更多
Helicobacter pylori(H pylori),a gastric pathogen,is a major cause of chronic gastritis and peptic ulcer disease,and is an important risk factor for the development of gastric malignancies.Culture of the bacterium from...Helicobacter pylori(H pylori),a gastric pathogen,is a major cause of chronic gastritis and peptic ulcer disease,and is an important risk factor for the development of gastric malignancies.Culture of the bacterium from gastric biopsy is essential for the determination of drug resistance of H pylori.However,the isolation rates of H pylori from infected individuals vary from 23.5%to 97% due to a number of factors such as biopsy preparation,cultural environment,medium and the method adopted.In the present case,we found that a prolonged incubation period of up to 19 d allowed successful isolation of H pylori from a patient who received triple therapy that failed to eradicate the bacterium.展开更多
Assessing and accounting for material consumption and environmental impact are necessary to measure environmental externalities of the aluminum industry and to construct an ecological civilization.In this research,lif...Assessing and accounting for material consumption and environmental impact are necessary to measure environmental externalities of the aluminum industry and to construct an ecological civilization.In this research,life cycle assessment(LCA)theory was used to assess the environmental impact of primary aluminum based on the lime soda Bayer process and different power generation modes,and the sources and distributions of the four selected impact categories were analyzed.The results show that,(1)Negative environmental impact of aluminum industry generally occurs from alumina extraction,carbon anode fabrication and electrolysis,particularly electrolysis and alumina extraction.Primary energy demand(PED),water use(WU),global warming potential(GWP)and freshwater eutrophication potential(FEP)are main environmental impact categories.(2)The environmental load with thermal power is higher than that with hydropower,e.g.,for the former,the greenhouse gas emission coefficient of 21800 kg CO2 eq/t(Al)will be generated,while for the latter,4910 kg CO2 eq/t(Al)will be generated.(3)Both power mode methods reflect the energy structure,whereas direct emissions reflect the technical level,indicating the potential for large energy savings and emission reductions,and some policies,related to clean power,energy efficiency and technological progress,should be made for emission reduction.展开更多
Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV ...Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.展开更多
Systolic implementation of multiplication over GF(2m) is usually very efficient in area-time complexity,but its latency is usually very large.Thus,two low latency systolic multipliers over GF(2m) based on general irre...Systolic implementation of multiplication over GF(2m) is usually very efficient in area-time complexity,but its latency is usually very large.Thus,two low latency systolic multipliers over GF(2m) based on general irreducible polynomials and irreducible pentanomials are presented.First,a signal flow graph(SFG) is used to represent the algorithm for multiplication over GF(2m).Then,the two low latency systolic structures for multiplications over GF(2m) based on general irreducible polynomials and pentanomials are presented from the SFG by suitable cut-set retiming,respectively.Analysis indicates that the proposed two low latency designs involve at least one-third less area-delay product when compared with the existing designs,To the authors' knowledge,the time-complexity of the structures is the lowest found in literature for systolic GF(2m) multipliers based on general irreducible polynomials and pentanomials.The proposed low latency designs are regular and modular,and therefore they are suitable for many time critical applications.展开更多
Violation of food and drug safety and other hazard crimes have the features of long latency and multiple factors. Traditional criminal law causality theory is no controversy to determine causality of criminal responsi...Violation of food and drug safety and other hazard crimes have the features of long latency and multiple factors. Traditional criminal law causality theory is no controversy to determine causality of criminal responsibility, thus it is necessary to introduce the epidemiology causality theory-it is a kind of causality theory based on epidemic diseases, and it is the high degree of probability in the determination of causality in criminal laws so as to solve the traditional attribution problem, but the theory also exists applicable restriction conditions in judicial practice.展开更多
Objective To assess the effects of sleep deprivation (SD) on the whole night polysomnography (PSG) in healthy young men. Methods The whole night PSG was recorded by using Neurofax-1518K (Nihon Kohden, Japan) system be...Objective To assess the effects of sleep deprivation (SD) on the whole night polysomnography (PSG) in healthy young men. Methods The whole night PSG was recorded by using Neurofax-1518K (Nihon Kohden, Japan) system before and after 38 h of SD among 15 healthy male subjects. Results Compared with PSG before SD, post-SD PSG showed significantly shortened sleep latency (before SD: 19.7±9.3, after SD: 5.6±7.3, P<0.05), decreased stage 1 (S1) non-rapid eye movement (NREM) sleep [before SD: (9.2±1.9)%, after SD: (4.0±1.4)%, P<0.05], and increased stage 4 (S4) NREM sleep [before SD: (10.3±3.7)%, after SD: (26.2±4.3)%, P<0.01]. Conclusion During post-SD sleep, the proportion of S4 NREM sleep was increased as compensation in healthy male. In addition, SD was proved to affect electrophysiological brain activities in normal people.展开更多
This paper is an exploratory study which investigates the introduction and implementation of management accounting changes in Australia. The study first examines the introduction of relatively new management accountin...This paper is an exploratory study which investigates the introduction and implementation of management accounting changes in Australia. The study first examines the introduction of relatively new management accounting techniques in professional journals, conferences, workshops, and professional development programs over a four-year period in Australia. These are among the main sources of transferring information on cost and management accounting changes to potential users in Australia. The purpose of such a study is to get a clear picture of the scope and extent of recently developed cost and management accounting techniques introduced to practitioners in Australia. By identifying the major management accounting changes and developments faced by organizations, the study then investigates the extent of implementations of such changes in practice. The study further explores the hindering and facilitating factors contributing to the implementation of new management accounting changes in organizations.展开更多
The location and late Quaternary activity of the Central-North Segment of the Taihang Mountains Piedmont fault zone have been studied by shallow seismic survey and combined drill exploration.Our results show that the ...The location and late Quaternary activity of the Central-North Segment of the Taihang Mountains Piedmont fault zone have been studied by shallow seismic survey and combined drill exploration.Our results show that the Baoding-Shijiazhuang fault and the Xushui fault were active in the late Pleistocene,but the south Xushui fault has been inactive since the late Pleistocene.The maximum magnitude of potential earthquake of the faults is 6.0.展开更多
文摘Objective: Optimization of combining electroencephalography (EEG), short latency somatosensory evoked potentials (SLSEP) and transcranial Doppler (TCD) techniques to diagnose brain death. Methods: One hundred and eleven patients (69 males, 42 females) from the major hospitals of Zhejiang Province were examined with portable EEG, SLSEP and TCD devices. Re-examinations occurred ≤12 h later. Results: The first examination revealed that the combination of SLSEP and EEG led to more sensitive diagnoses than the combination of SLSEP and TCD. Re-examination confirmed this and also revealed that the combination of TCD and EEG was the most sensitive. Conclusion: The results show that using multiple techniques to diagnose brain death is superior to using single method, and that the combination of SLSEP and EEG is better than other combinations.
基金Supported by the Grant From Ministry of Sciences and Technology of China, No.96-901-01 -45
文摘AIM: To study the toxicity of bicyclol to animals. METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats were orally administered bicyclol at a dose of 5 g/kg body weight. Death and clinical symptoms of animals were recorded within 7 d. Sub-acute toxicity test was carried out in rats that were treated with various doses of bicyclol (150, 300, 600 mg/kg) once daily for 14 d. Animal behaviors, blood biochemical markers, blood and urine pictures were examined. Chronic toxicity test was conducted in 80 Wistar rats of both sexes. The animals were orally administered with various doses of bicyclol [150, 300, 600 mg/kg, 100-400 folds corresponding to the proposed therapeutic dose (1.5 mg/(kg·d)) of bicyclol for patients] once daily for 6 mo except for Sunday. The control group was given the same volume of 0.2% sodium carboxyl methylcellulose (Na-CMC). Twenty-one beagle dogs received bicyclol (25, 75, 225 mg/kg, 16.6, 50, 150 folds corresponding to the proposed therapeutic dose of bicyclol for patients) once a day for 6 mo except for Sunday. The body weight, food intake, urine and feces, blood picture, blood biochemical markers, and pathological examination of main organs were determined. Mutagenicity and teratogenicity were determined. Mutagenicity assay included Ames's test, chromosome aberration test in CHL cells and micronucleus test in mice. For the teratogenicity assay, pregnant Wistar rats weighing 200-250 g were treated with 0.2,1.0 g/kg bicyclol once daily from the 7th d of gestation for 10 d. RESULTS: The oral LD50 of bicyclol was over 5 g/kg in mice and rats. No noticeable alterations in subacute and chronic toxicity of rats and dogs were demonstrated. No mutagenicity and teratogenicity of bicyclol were found. CONCLUSION: Bicyclol has no detectable chronic toxicity as well as mutagenicity and teratogenicity in animals.
基金Supported by The Grant"Research of the Helicobacter pylori gene engineering vaccine"from Hi-tech research and development(863)program of China,Grant No.2001AA21516102National Science and Technology Infrastructure Program,Grant No.2007BAI04B02
文摘Helicobacter pylori(H pylori),a gastric pathogen,is a major cause of chronic gastritis and peptic ulcer disease,and is an important risk factor for the development of gastric malignancies.Culture of the bacterium from gastric biopsy is essential for the determination of drug resistance of H pylori.However,the isolation rates of H pylori from infected individuals vary from 23.5%to 97% due to a number of factors such as biopsy preparation,cultural environment,medium and the method adopted.In the present case,we found that a prolonged incubation period of up to 19 d allowed successful isolation of H pylori from a patient who received triple therapy that failed to eradicate the bacterium.
基金Projects(71633006,71403298) supported by the National Natural Science Foundation of ChinaProjects(14YJCZH045,15YJCZH019) supported by the Ministry of Education of Humanities and Social Science,China
文摘Assessing and accounting for material consumption and environmental impact are necessary to measure environmental externalities of the aluminum industry and to construct an ecological civilization.In this research,life cycle assessment(LCA)theory was used to assess the environmental impact of primary aluminum based on the lime soda Bayer process and different power generation modes,and the sources and distributions of the four selected impact categories were analyzed.The results show that,(1)Negative environmental impact of aluminum industry generally occurs from alumina extraction,carbon anode fabrication and electrolysis,particularly electrolysis and alumina extraction.Primary energy demand(PED),water use(WU),global warming potential(GWP)and freshwater eutrophication potential(FEP)are main environmental impact categories.(2)The environmental load with thermal power is higher than that with hydropower,e.g.,for the former,the greenhouse gas emission coefficient of 21800 kg CO2 eq/t(Al)will be generated,while for the latter,4910 kg CO2 eq/t(Al)will be generated.(3)Both power mode methods reflect the energy structure,whereas direct emissions reflect the technical level,indicating the potential for large energy savings and emission reductions,and some policies,related to clean power,energy efficiency and technological progress,should be made for emission reduction.
基金supported by the Japan Society for the Promotion of Science KAKENHI 17K08348 and 21K06619(Wei Li).
文摘Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.
基金Project(61174132) supported by the National Natural Science Foundation of ChinaProject(09JJ6098) supported by the Natural Science Foundation of Hunan Province,China
文摘Systolic implementation of multiplication over GF(2m) is usually very efficient in area-time complexity,but its latency is usually very large.Thus,two low latency systolic multipliers over GF(2m) based on general irreducible polynomials and irreducible pentanomials are presented.First,a signal flow graph(SFG) is used to represent the algorithm for multiplication over GF(2m).Then,the two low latency systolic structures for multiplications over GF(2m) based on general irreducible polynomials and pentanomials are presented from the SFG by suitable cut-set retiming,respectively.Analysis indicates that the proposed two low latency designs involve at least one-third less area-delay product when compared with the existing designs,To the authors' knowledge,the time-complexity of the structures is the lowest found in literature for systolic GF(2m) multipliers based on general irreducible polynomials and pentanomials.The proposed low latency designs are regular and modular,and therefore they are suitable for many time critical applications.
文摘Violation of food and drug safety and other hazard crimes have the features of long latency and multiple factors. Traditional criminal law causality theory is no controversy to determine causality of criminal responsibility, thus it is necessary to introduce the epidemiology causality theory-it is a kind of causality theory based on epidemic diseases, and it is the high degree of probability in the determination of causality in criminal laws so as to solve the traditional attribution problem, but the theory also exists applicable restriction conditions in judicial practice.
基金Supported by National High Technology Research and Development Program of China (863 Program, No.2007AA02Z420 and No.2008AA02Z412)Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals (No.SHDC12006105)+1 种基金Foundation of the National Natural Science Foundation of China (No.30770772)the Municipal Committee of Shanghai Science and Technology (No.09411968200)
文摘Objective To assess the effects of sleep deprivation (SD) on the whole night polysomnography (PSG) in healthy young men. Methods The whole night PSG was recorded by using Neurofax-1518K (Nihon Kohden, Japan) system before and after 38 h of SD among 15 healthy male subjects. Results Compared with PSG before SD, post-SD PSG showed significantly shortened sleep latency (before SD: 19.7±9.3, after SD: 5.6±7.3, P<0.05), decreased stage 1 (S1) non-rapid eye movement (NREM) sleep [before SD: (9.2±1.9)%, after SD: (4.0±1.4)%, P<0.05], and increased stage 4 (S4) NREM sleep [before SD: (10.3±3.7)%, after SD: (26.2±4.3)%, P<0.01]. Conclusion During post-SD sleep, the proportion of S4 NREM sleep was increased as compensation in healthy male. In addition, SD was proved to affect electrophysiological brain activities in normal people.
文摘This paper is an exploratory study which investigates the introduction and implementation of management accounting changes in Australia. The study first examines the introduction of relatively new management accounting techniques in professional journals, conferences, workshops, and professional development programs over a four-year period in Australia. These are among the main sources of transferring information on cost and management accounting changes to potential users in Australia. The purpose of such a study is to get a clear picture of the scope and extent of recently developed cost and management accounting techniques introduced to practitioners in Australia. By identifying the major management accounting changes and developments faced by organizations, the study then investigates the extent of implementations of such changes in practice. The study further explores the hindering and facilitating factors contributing to the implementation of new management accounting changes in organizations.
基金sponsored by Active Faults Seismic Hazard Assessment in Key Earthquake Monitoring and Defensive Region of China
文摘The location and late Quaternary activity of the Central-North Segment of the Taihang Mountains Piedmont fault zone have been studied by shallow seismic survey and combined drill exploration.Our results show that the Baoding-Shijiazhuang fault and the Xushui fault were active in the late Pleistocene,but the south Xushui fault has been inactive since the late Pleistocene.The maximum magnitude of potential earthquake of the faults is 6.0.