This study systematically examined the dissolution behavior of furazolidone in 12 different pure solvents and in aqueous solutions containing ethylenediaminetetraacetic acid disodium salt(EDTA-2Na).The solubility data...This study systematically examined the dissolution behavior of furazolidone in 12 different pure solvents and in aqueous solutions containing ethylenediaminetetraacetic acid disodium salt(EDTA-2Na).The solubility data indicated that polar aprotic solvents demonstrated a marginally higher solubility of furazolidone compared to alcohols and water.Interestingly,a co-solvency effect was observed in the aqueous solutions of EDTA-2Na,where the solubility of furazolidone initially increased and then decreased with the gradual addition of EDTA-2Na,peaking at a mass fraction of 0.03(1.949×10^(–5)at 323.15 K).The analysis using the Kamlet-Abboud-Taft Linear Solvation Energy Relationship(KAT-LSER)model suggested that the dissolution of furazolidone in these systems was predominantly influenced by non-specific solute-solvent and solvent-solvent interactions.Furthermore,Hansen solubility parameter calculations revealed that N,N-dimethylformamide(DMF)and N,N-dimethylacetamide(DMAC)exhibited superior dissolution capabilities compared to other solvents.It was also found that the partial solubility parameters played a crucial role in determining the overall solubility behavior.展开更多
基金Innovation and Entrepreneurship Training Program for College Students in Shanxi Province (Grant No. 2021100)。
文摘This study systematically examined the dissolution behavior of furazolidone in 12 different pure solvents and in aqueous solutions containing ethylenediaminetetraacetic acid disodium salt(EDTA-2Na).The solubility data indicated that polar aprotic solvents demonstrated a marginally higher solubility of furazolidone compared to alcohols and water.Interestingly,a co-solvency effect was observed in the aqueous solutions of EDTA-2Na,where the solubility of furazolidone initially increased and then decreased with the gradual addition of EDTA-2Na,peaking at a mass fraction of 0.03(1.949×10^(–5)at 323.15 K).The analysis using the Kamlet-Abboud-Taft Linear Solvation Energy Relationship(KAT-LSER)model suggested that the dissolution of furazolidone in these systems was predominantly influenced by non-specific solute-solvent and solvent-solvent interactions.Furthermore,Hansen solubility parameter calculations revealed that N,N-dimethylformamide(DMF)and N,N-dimethylacetamide(DMAC)exhibited superior dissolution capabilities compared to other solvents.It was also found that the partial solubility parameters played a crucial role in determining the overall solubility behavior.
