目的探讨烟酸皮肤潮红反应在抑郁症患者与健康对照者之间的差异,及其用于抑郁症诊断的价值。方法纳入未用药抑郁症急性发作患者21例及年龄、性别匹配的健康对照28名,收集一般人口学与临床资料,均采用8个浓度梯度(10^(-5)mol/L、10^(-4)m...目的探讨烟酸皮肤潮红反应在抑郁症患者与健康对照者之间的差异,及其用于抑郁症诊断的价值。方法纳入未用药抑郁症急性发作患者21例及年龄、性别匹配的健康对照28名,收集一般人口学与临床资料,均采用8个浓度梯度(10^(-5)mol/L、10^(-4)mol/L、10^(-3.5)mol/L、10^(-3)mol/L、10^(-2.5)mol/L、10^(-2)mol/L、10^(-1.5)mol/L、10^(-1)mol/L)烟酸溶液刺激双前臂皮肤,应用激光多普勒血流仪采集血流灌注量等信号以评价受试者的皮肤潮红情况。结果抑郁症患者在不同浓度(10^(-2.5)mol/L、10^(-2)mol/L、10^(-1.5)mol/L、10^(-1)mol/L)烟酸溶液刺激下,其皮肤血流量与对照相比升高有统计学意义(P<0.01)。患者烟酸敏感性(the logarithm of median effect concentration,logEC50)与抑郁严重程度呈反比(r=-0.57,P=0.01)。由烟酸皮肤潮红反应引起的最大反应血流量(maximal blood flow,MBF)可有效区分抑郁症组和对照组(AUC=0.90,P<0.01)。结论抑郁症患者存在烟酸皮肤潮红反应亢进,烟酸皮肤潮红反应可能有助于抑郁症的诊断。展开更多
Flushing has been associated with medications, rosacea, menopause, carcinoid syndrome, pheochromocytoma, polycythemia, and mastocytosis, although it can occur without known cause. There are no known specific treatment...Flushing has been associated with medications, rosacea, menopause, carcinoid syndrome, pheochromocytoma, polycythemia, and mastocytosis, although it can occur without known cause. There are no known specific treatments available, but β - blockers have suppressed flushing reactions in some patients, particularly when associated with anxiety. The medical histories and clinical characteristics of 9 patients with either idiopathic flushing or flushing associated with rosacea were reviewed. Eight patients experienced subjective improvement with propranolol therapy.展开更多
文摘目的探讨烟酸皮肤潮红反应在抑郁症患者与健康对照者之间的差异,及其用于抑郁症诊断的价值。方法纳入未用药抑郁症急性发作患者21例及年龄、性别匹配的健康对照28名,收集一般人口学与临床资料,均采用8个浓度梯度(10^(-5)mol/L、10^(-4)mol/L、10^(-3.5)mol/L、10^(-3)mol/L、10^(-2.5)mol/L、10^(-2)mol/L、10^(-1.5)mol/L、10^(-1)mol/L)烟酸溶液刺激双前臂皮肤,应用激光多普勒血流仪采集血流灌注量等信号以评价受试者的皮肤潮红情况。结果抑郁症患者在不同浓度(10^(-2.5)mol/L、10^(-2)mol/L、10^(-1.5)mol/L、10^(-1)mol/L)烟酸溶液刺激下,其皮肤血流量与对照相比升高有统计学意义(P<0.01)。患者烟酸敏感性(the logarithm of median effect concentration,logEC50)与抑郁严重程度呈反比(r=-0.57,P=0.01)。由烟酸皮肤潮红反应引起的最大反应血流量(maximal blood flow,MBF)可有效区分抑郁症组和对照组(AUC=0.90,P<0.01)。结论抑郁症患者存在烟酸皮肤潮红反应亢进,烟酸皮肤潮红反应可能有助于抑郁症的诊断。
文摘Flushing has been associated with medications, rosacea, menopause, carcinoid syndrome, pheochromocytoma, polycythemia, and mastocytosis, although it can occur without known cause. There are no known specific treatments available, but β - blockers have suppressed flushing reactions in some patients, particularly when associated with anxiety. The medical histories and clinical characteristics of 9 patients with either idiopathic flushing or flushing associated with rosacea were reviewed. Eight patients experienced subjective improvement with propranolol therapy.
