业已开发了一种用激光直接描绘淀积W薄膜的技术。它是一种在电路制成之后,可以方便而又灵活地修正GaAsMMIC的方法。用一个微米级定位精度的聚焦氩离子激光束诱导的气相化学反应,在GaAs衬底上淀积电阻率为30μΩ·cm的W微带线。淀积...业已开发了一种用激光直接描绘淀积W薄膜的技术。它是一种在电路制成之后,可以方便而又灵活地修正GaAsMMIC的方法。用一个微米级定位精度的聚焦氩离子激光束诱导的气相化学反应,在GaAs衬底上淀积电阻率为30μΩ·cm的W微带线。淀积的W微带线也很容易用激光烧蚀法去除。已用这种方法制备的W微带线成功地调配了一个8GHz GaAs MES FET放大器和一个30GHz单片衰减器。展开更多
A high power and low distortion 1.31 μm AlGaInAs/InP multiquantum well distributed feedback laser diode (MQW DFB LD) with RWG structure has been developed by MOCVD technique. The fiber output power of butterfly packa...A high power and low distortion 1.31 μm AlGaInAs/InP multiquantum well distributed feedback laser diode (MQW DFB LD) with RWG structure has been developed by MOCVD technique. The fiber output power of butterfly packaged module with optic isolator P f is more than 10 mW, threshold current is in the range of (13～20) mA, slope efficiency, E s>0.30 W/A and side mode suppression ratio, R S,M,S >35 dB. The composite second order, O C,S <-61 dBc and composite triple beat, B C,T <-65 dBc are obtained by test frequencies of (45～550) MHz with 60 PAL channels. In the test conditions the carrier to noise ratio, R C,N >51 dB.展开更多
Deferasirox is the first-line drug for iron overload due to thalassemia in adults and pediatric patients. It is classified as a type II compound in the Biopharmaceutics Classification System, and thus the particle siz...Deferasirox is the first-line drug for iron overload due to thalassemia in adults and pediatric patients. It is classified as a type II compound in the Biopharmaceutics Classification System, and thus the particle size of its active pharmaceutical ingredient(API) should be strictly controlled during the manufacturing process. In the present study, laser diffraction was adopted to measure the particle size distribution of deferasirox API. We also developed and validated an accurate and convenient method by investigating important optical parameters and sample dispersing conditions. The relative standard deviation values, namely, d(0.1), d(0.5), d(0.9), and d(4,3), measured via methodology validation and actual sample measurement were < 3%. The dissolution curves of several batches of dispersible tablets prepared using deferasirox with different particle sizes were compared in the four dissolved media to investigate the influence of particle size on drug dissolution in vitro. Results indicated that the particle size distribution of deferasirox API significantly affected the release of its dispersible tablet.展开更多
文摘业已开发了一种用激光直接描绘淀积W薄膜的技术。它是一种在电路制成之后,可以方便而又灵活地修正GaAsMMIC的方法。用一个微米级定位精度的聚焦氩离子激光束诱导的气相化学反应,在GaAs衬底上淀积电阻率为30μΩ·cm的W微带线。淀积的W微带线也很容易用激光烧蚀法去除。已用这种方法制备的W微带线成功地调配了一个8GHz GaAs MES FET放大器和一个30GHz单片衰减器。
文摘A high power and low distortion 1.31 μm AlGaInAs/InP multiquantum well distributed feedback laser diode (MQW DFB LD) with RWG structure has been developed by MOCVD technique. The fiber output power of butterfly packaged module with optic isolator P f is more than 10 mW, threshold current is in the range of (13～20) mA, slope efficiency, E s>0.30 W/A and side mode suppression ratio, R S,M,S >35 dB. The composite second order, O C,S <-61 dBc and composite triple beat, B C,T <-65 dBc are obtained by test frequencies of (45～550) MHz with 60 PAL channels. In the test conditions the carrier to noise ratio, R C,N >51 dB.
基金CAMS Innovation Fund for Medical Sciences(CIFMS No.2016-I2M-3-010 and CIFMS No.2017-I2M-1-011)。
文摘Deferasirox is the first-line drug for iron overload due to thalassemia in adults and pediatric patients. It is classified as a type II compound in the Biopharmaceutics Classification System, and thus the particle size of its active pharmaceutical ingredient(API) should be strictly controlled during the manufacturing process. In the present study, laser diffraction was adopted to measure the particle size distribution of deferasirox API. We also developed and validated an accurate and convenient method by investigating important optical parameters and sample dispersing conditions. The relative standard deviation values, namely, d(0.1), d(0.5), d(0.9), and d(4,3), measured via methodology validation and actual sample measurement were < 3%. The dissolution curves of several batches of dispersible tablets prepared using deferasirox with different particle sizes were compared in the four dissolved media to investigate the influence of particle size on drug dissolution in vitro. Results indicated that the particle size distribution of deferasirox API significantly affected the release of its dispersible tablet.
