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不同标记线制备方法对脊柱连接棒疲劳性能的影响
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作者 赵鑫 王春 +3 位作者 罗团飞 张述 刘梦星 石杜芳 《医用生物力学》 CAS CSCD 北大核心 2023年第6期1167-1172,共6页
目的 研究不同标记线制备工艺对脊柱后路内固定系统连接棒疲劳性能和系统压缩疲劳性能的影响。方法 根据YY/T 0119.4—2014标准对脊柱连接棒进行4点弯曲疲劳测试。在一定应力作用下,依据YY/T 0857—2011对激光标记线连接棒和双色彩氧标... 目的 研究不同标记线制备工艺对脊柱后路内固定系统连接棒疲劳性能和系统压缩疲劳性能的影响。方法 根据YY/T 0119.4—2014标准对脊柱连接棒进行4点弯曲疲劳测试。在一定应力作用下,依据YY/T 0857—2011对激光标记线连接棒和双色彩氧标记线连接棒进行系统压缩疲劳试验。结果 在715 MPa应力下,自制激光标记线连接棒和竞品厂家激光标记线连接棒疲劳寿命较无标记线连接棒分别下降了95%和98%;与未标记连接棒相比,激光标记连接棒疲劳强度由742 MPa下降至342 MPa,降低了54%。双色彩氧连接棒的疲劳寿命和疲劳强度与无标记线连接棒相当。双色彩氧连接棒系统压缩疲劳强度较激光标记连接棒提高约20%。结论 激光制备标记线显著降低了脊柱连接棒的疲劳性能和系统的压缩疲劳强度,改进的双色彩氧工艺制备标记线对连接棒的疲劳性能无影响,能有效降低临床断裂风险,为连接棒的性能改善和工艺开发提供参考。 展开更多
关键词 连接棒 激光标记线 双色彩氧标记线 疲劳性能
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Comparative study on different derivatization procedures for analysis of recombinant human erythropoietin by capillary electrophoresis with laser-induced fluorescence detection
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作者 杨霞 庞楠楠 +3 位作者 付晓芳 尹红锋 廖一平 刘虎威 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第5期317-323,共7页
Human erythropoietin (hEPO), an endogenous glycoprotein, plays a fundamental role in erythropoiesis controlling the formation of red blood cells. Production of recombinant human erythropoietin (rhEPO) has made it ... Human erythropoietin (hEPO), an endogenous glycoprotein, plays a fundamental role in erythropoiesis controlling the formation of red blood cells. Production of recombinant human erythropoietin (rhEPO) has made it possible for its abuse in competitive sports. In this work, pre-capillary and on-capillary derivatization by 5-furoylquinoline-3-carboxaldehyde (FQ) and fluorescein isothiocyanate (FITC) for the detection of rhEPO by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) were compared. FQ pre-capillary labeling improves sensitivity but degrades the glycoforms separation due to the inhomogeneity of the reaction products from multiple labeling. Compared with FITC pre-capillary derivatization with the excess fluorescent background, the on-capillary FQ derivatization method can provide shorter analysis time, lower background, and better selectivity. It is demonstrated that, through optimizing reaction conditions of FQ on-capillary derivatization, both high sensitivity and satisfactory resolution for the analysis of the be used for the glycoforms profiling and quality control of rhEPO doping control analysis. glycoforms of rhEPO could be obtained. This method can It may be used as a candidate method for fast screening in 展开更多
关键词 Recombinant human erythropoietin Capillary electrophoresis Laser-induced fluorescence detection On-capillaryderivatization
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