Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases a...Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.展开更多
The tunable excitation patterns and emission modes associated with luminescence materials,such as downshifting luminescence(DSL),upconversion luminescence(UCL),and mechanoluminescence(ML)play an important role in info...The tunable excitation patterns and emission modes associated with luminescence materials,such as downshifting luminescence(DSL),upconversion luminescence(UCL),and mechanoluminescence(ML)play an important role in information encryption and anticounterfeiting.However,many reported luminescence materials usually show fixed excitation patterns and unimodal output,resulting in a low anticounterfeiting level.Therefore,developing luminescence materials with multitemporal,variation excitation patterns and multiple emission modes remains a considerable challenge,particularly in a single matrix.This study reports a highly integrated multifunctional material(color-tunable(DSL:amaranth→blue),tunable excitation patterns(250±380 nm)and quadrimodal(DSL,UCL,persistent luminescence(PersL),and ML)).The as-obtained versatile LaCaAl_(3)O_(7):Eu^(2+)/^(3+),Yb^(3+),Er^(3+)materials are suitable for obtaining elastomer films with the characteristics of water resistance,stretchability,and flexibility and synchronously offer multidimensional information encryptions and anticounterfeiting using common tools(ultraviolet light,nearinfrared light,and pen).These results provide a unique insight into advanced multimodal anticounterfeiting.展开更多
基金Supported by China Academy of Chinese Medical Sciences:ZZ0908019
文摘Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.
基金supported by the National Natural Science Foundation of China(21871122 and 21431002)the Fundamental Research Funds for the Central Universities(lzujbky-2021-kb17)。
文摘The tunable excitation patterns and emission modes associated with luminescence materials,such as downshifting luminescence(DSL),upconversion luminescence(UCL),and mechanoluminescence(ML)play an important role in information encryption and anticounterfeiting.However,many reported luminescence materials usually show fixed excitation patterns and unimodal output,resulting in a low anticounterfeiting level.Therefore,developing luminescence materials with multitemporal,variation excitation patterns and multiple emission modes remains a considerable challenge,particularly in a single matrix.This study reports a highly integrated multifunctional material(color-tunable(DSL:amaranth→blue),tunable excitation patterns(250±380 nm)and quadrimodal(DSL,UCL,persistent luminescence(PersL),and ML)).The as-obtained versatile LaCaAl_(3)O_(7):Eu^(2+)/^(3+),Yb^(3+),Er^(3+)materials are suitable for obtaining elastomer films with the characteristics of water resistance,stretchability,and flexibility and synchronously offer multidimensional information encryptions and anticounterfeiting using common tools(ultraviolet light,nearinfrared light,and pen).These results provide a unique insight into advanced multimodal anticounterfeiting.
