The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation und...The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation under various activated conditions (UV 254 nm /PS,Thermal (70°C/PS,UV 254 nm /PMS,Co 2+ /PMS) were investigated.Methanol and NH4 + were used as quenching reagents to determine the contributions of active chlorine species (dichloride radical (Cl2-.) and hypochlorous acid (HClO)).The results indicated that the effects of Cl- on the reaction mechanism were different under various activated conditions.For UV/PS and Thermal/PS,the inhibition tendency became more clear as the Cl- concentration increased,probably due to the reaction between Cl- and SO4-.and the generation of Cl2-.or HClO.For UV/PMS,Cl- did not exhibit inhibition when the concentration was below 0.1 mol/L.As Cl- concentration reached to 1.0 mol/L,the decolorization rate of AO7 was,however,accelerated,possibly because PMS directly reacts with Cl- to form HClO.For Co2+ /PMS,Cl- exhibited a significant inhibiting effect even at low concentration ( 0.01 mol/L).When Cl- concentration exceeded 0.1 mol/L,the activation of PMS by Co 2+ was almost completely inhibited.Under this condition,HClO maybe played a major role in decolorization of AO7.The results implicated that chloride ion is an important factor in SO4-.-based degradation of organic contamination in chloride-containing water.展开更多
BA3011(CAB-AXL-ADC)是BioAtla公司开发的新型肿瘤微环境条件性激活的Axl受体靶向抗体偶联药物。其抗体部分通过条件性激活技术(conditionally active biologics,CAB)改造后,能选择性靶向于肿瘤组织的Axl受体。BA3011已获批进行Ⅰ/Ⅱ期...BA3011(CAB-AXL-ADC)是BioAtla公司开发的新型肿瘤微环境条件性激活的Axl受体靶向抗体偶联药物。其抗体部分通过条件性激活技术(conditionally active biologics,CAB)改造后,能选择性靶向于肿瘤组织的Axl受体。BA3011已获批进行Ⅰ/Ⅱ期临床试验,适应证包括非小细胞肺癌、去势抵抗性前列腺癌和胰腺癌等晚期实体瘤。BA3011是首个进入临床试验的CAB产品,标志着CAB由技术研发阶段跨入产品开发阶段。本文就Axl受体为靶标的药物,CAB技术和BA3011的临床进展情况作一概述。展开更多
基金Supported by the National Natural Science Foundation of China （51104063, 51074071） the Scientific Research Fund of Hunan Provincial Education Department （10C0665）+1 种基金 the Open Foundation of Htman Key Laboratory of Safe Mining Techniques of Coal Mines （200904） the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Htman Province
基金supported by the National Natural Science Foundation of China (No. 21107101)the Fundamental Research Funds for the Central Universities of China (Ocean University of China)(No.201113005)
文摘The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation under various activated conditions (UV 254 nm /PS,Thermal (70°C/PS,UV 254 nm /PMS,Co 2+ /PMS) were investigated.Methanol and NH4 + were used as quenching reagents to determine the contributions of active chlorine species (dichloride radical (Cl2-.) and hypochlorous acid (HClO)).The results indicated that the effects of Cl- on the reaction mechanism were different under various activated conditions.For UV/PS and Thermal/PS,the inhibition tendency became more clear as the Cl- concentration increased,probably due to the reaction between Cl- and SO4-.and the generation of Cl2-.or HClO.For UV/PMS,Cl- did not exhibit inhibition when the concentration was below 0.1 mol/L.As Cl- concentration reached to 1.0 mol/L,the decolorization rate of AO7 was,however,accelerated,possibly because PMS directly reacts with Cl- to form HClO.For Co2+ /PMS,Cl- exhibited a significant inhibiting effect even at low concentration ( 0.01 mol/L).When Cl- concentration exceeded 0.1 mol/L,the activation of PMS by Co 2+ was almost completely inhibited.Under this condition,HClO maybe played a major role in decolorization of AO7.The results implicated that chloride ion is an important factor in SO4-.-based degradation of organic contamination in chloride-containing water.
文摘BA3011(CAB-AXL-ADC)是BioAtla公司开发的新型肿瘤微环境条件性激活的Axl受体靶向抗体偶联药物。其抗体部分通过条件性激活技术(conditionally active biologics,CAB)改造后,能选择性靶向于肿瘤组织的Axl受体。BA3011已获批进行Ⅰ/Ⅱ期临床试验,适应证包括非小细胞肺癌、去势抵抗性前列腺癌和胰腺癌等晚期实体瘤。BA3011是首个进入临床试验的CAB产品,标志着CAB由技术研发阶段跨入产品开发阶段。本文就Axl受体为靶标的药物,CAB技术和BA3011的临床进展情况作一概述。
