To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current(MMC-HVDC)systems and streamline the simulation process for determining MMC impedanc...To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current(MMC-HVDC)systems and streamline the simulation process for determining MMC impedance characteristics,a simplified mathematical simulation model for MMC closed-loop impedance is developed using the harmonic state space method.This model considers various control strategies and includes both AC-side and DC-side impedance models.By applying a Nyquist criterion-based impedance analysis method,the stability mechanisms on the AC and DC sides of the MMC are examined.In addition,a data-driven oscillation stability analysis method is also proposed,leveraging a global sensitivity algorithm based on fast model results to identify key parameters influencing MMC oscillation stability.Based on sensitivity analysis results,a parameter adjustment strategy for oscillation suppression is proposed.The simulation results from the MATLAB/Simulinkbased MMC model validate the effectiveness of the proposed method.展开更多
Although the genetic algorithm (GA) has very powerful robustness and fitness, it needs a large size of population and a large number of iterations to reach the optimum result. Especially when GA is used in complex str...Although the genetic algorithm (GA) has very powerful robustness and fitness, it needs a large size of population and a large number of iterations to reach the optimum result. Especially when GA is used in complex structural optimization problems, if the structural reanalysis technique is not adopted, the more the number of finite element analysis (FEA) is, the more the consuming time is. In the conventional structural optimization the number of FEA can be reduced by the structural reanalysis technique based on the approximation techniques and sensitivity analysis. With these techniques, this paper provides a new approximation model-segment approximation model, adopted for the GA application. This segment approximation model can decrease the number of FEA and increase the convergence rate of GA. So it can apparently decrease the computation time of GA. Two examples demonstrate the availability of the new segment approximation model.展开更多
For a detector in a capacitanee fuze working in an electrostatic field, the bomblength (effective length of the conductor part) is an important factor affecting the sensitivityof detection. For the two different kinds...For a detector in a capacitanee fuze working in an electrostatic field, the bomblength (effective length of the conductor part) is an important factor affecting the sensitivityof detection. For the two different kinds of detecting circuit models in general use (the frequency-sensitive and the amplitude-coupling ), mechanism of the effect of bomblength on the sensitvity of detection is analyzed. Through the analysis a conclusion in fullagreement with experimental results has been drawn, that is. the longer the bomb length,the higher the sensitivity, on the condition that the sizes and the sites of the detecting electrodes and bomb diameter remain unchanged.展开更多
This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensiti...This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensitivity analysis of such forecasts. This sensitivity analysis could furnish guidance in the selection of targeted observations. The study was performed by conducting observation system experiments (OSEs). This research used the fifth-generation Mesoscale Model (MM5), the Weather Research and Forecasting (WRF) model, and dropsonde observations of Typhoon Nida at 1200 UTC 17 May 2004. The dropsondes were collected under the operational Dropsonde Observations for Typhoon Surveillance near the Taiwan Region (DOTSTAR) program. In this research, five kinds of experiments were designed and conducted:(1) no observations were assimilated; (2) all observations were assimilated;(3) observations in the sensitive area revealed by the CNOP method were assimilated;(4) the same as in (3), but for the region revealed by the first singular vector (FSV) method;and (5) observations within a randomly selected area were assimilated. The OSEs showed that (1) the DOTSTAR data had a positive impact on the forecast of Nida's track;(2) dropsondes in the sensitive areas identified by the MM5 CNOP and FSV remained effective for improving the track forecast for Nida on the WRF platform;and (3) the greatest improvement in the track forecast resulted from the CNOP-based (third) simulation, which indicated that the CNOP method would be useful in decision making about dropsonde deployments.展开更多
AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other ora...AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le.展开更多
A signal optimization model for roundabout was control concept were used to eliminate the conflict points proposed based on dual-ring scheme and two stop lines for left turns and weaving sections at a roundabout. A cy...A signal optimization model for roundabout was control concept were used to eliminate the conflict points proposed based on dual-ring scheme and two stop lines for left turns and weaving sections at a roundabout. A cycle length minimization problem was considered to generate optimal signal timings for roundabout, and a set of constraints to ensure feasibility and safety of the resulting optimal signal settings were proposed. Extensive experimental analyses in comparison with signalized intersection reveal that the proposed model is quite promising for application in design of roundabout signals, and the minimum cycle length can decrease from 186 s to 79 s while the capacity increases from 8 682 pcu/h to 9 011 pcu/h under high demand scenario. Sensitivity analysis with respect to the system performance show that the lane assignment plan, number of circulatory lanes and left turn ratio are three critical factors which have dominate impacts on performance of signalized roundabout展开更多
In order to describe and control the stress distribution and total deformation of bladed disk assemblies used in the aeroengine, a highly efficient and precise method of probabilistic analysis which is called extremum...In order to describe and control the stress distribution and total deformation of bladed disk assemblies used in the aeroengine, a highly efficient and precise method of probabilistic analysis which is called extremum response surface method(ERSM) is produced based on the previous deterministic analysis results with the finite element model(FEM). In this work, many key nonlinear factors, such as the dynamic feature of the temperature load, the centrifugal force and the boundary conditions, are taken into consideration for the model. The changing patterns with time of bladed disk assemblies about stress distribution and total deformation are obtained during the deterministic analysis, and at the same time, the largest deformation and stress nodes of bladed disk assemblies are found and taken as input target of probabilistic analysis in a scientific and reasonable way. Not only their reliability, historical sample, extreme response surface(ERS) and the cumulative probability distribution function but also their sensitivity and effect probability are obtained. Main factors affecting stress distribution and total deformation of bladed disk assemblies are investigated through the sensitivity analysis of the model. Finally, compared with the response surface method(RSM) and the Monte Carlo simulation(MCS), the results show that this new approach is effective.展开更多
Monitoring the stability of steep slopes of open-pit mines is a major issue relating to production safety in mines.In order to determine the technical parameters of a new type of supervising system applied in monitori...Monitoring the stability of steep slopes of open-pit mines is a major issue relating to production safety in mines.In order to determine the technical parameters of a new type of supervising system applied in monitoring steep slopes of open-pit mines,the MSARMA method was used to establish analytical models for the monitoring system,given various parameter settings based on the description of mechanical monitoring principles.We used this sensitivity analysis to conclude that the setting of the most sensitive location of a mechanical monitoring system should be within a range of 1/5~1/2 of the lower part in a vertical direction of steep slopes,with a rational and feasible range of the dip angle setting between 0°~20°.Given the analytical results of our on-site experiments,we have shown that the parameters determined reflect the stability of steep slopes accurately and effectively.These conclusions provide a basis for the application of a new type of steep slope stability monitoring technology in open-pit mines.展开更多
A novel conditional cell transmission model (CCTM) is a potential simulation tool because it accommodates all traffic conditions from light condition to oversaturated condition. To test the performance of the CCTM, ...A novel conditional cell transmission model (CCTM) is a potential simulation tool because it accommodates all traffic conditions from light condition to oversaturated condition. To test the performance of the CCTM, a series of experiments for sensitivity analysis were designed and performed for a multilane, two-way, three-signal sample network. Experiment 1 shows that the model is performed in a logical and expected manner with variations in traffic demand with time and direction. Experiment 2 shows when the possibility of the occurrence of a useful gap increases to 60% and 100%, the delays in left rams decrease by 5% and 15%, respectively. In Experiment 3, comparing the possibility of a conditional cell of 0 with 100%, delay of left turn and delay of the entire network were underestimated by 58% and 11%, respectively. Hence, sensitivity analysis demonstrates that by reflecting local drivers' behaviors properly, the CCTM provides an accurate representation of traffic flow in simulating oversaturated traffic conditions.展开更多
A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a min...A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a mine, operators need to know the cause and effect of any changes requested from the VOD system. The sensitivity analysis is developed through generating a cause and effect matrix of sensitivity factors on given parameter changes in a ventilation system. This new utility, which was incorporated in the 3D-CANVENT mine ventilation simulator, is able to predict the airflow distributions in a ventilation network when underground conditions and ventilation controls are changed. For a primary ventilation system, the software can determine the optimal operating speed of the main fans to satisfy the airflow requirements in underground workings without necessarily using booster fans and regulators locally. An optimized fan operating speed time-table would assure variable demand-based fresh air delivery to the production areas effectively, while generating significant savings in energy consumption and operating cost.展开更多
Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases ...Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods: The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted. Results: Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined: in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 (SE=0.0S), with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 (SE=0.04), with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated: in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 (SE=0.05), with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 (SE=0.05), with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 (SE=0.05), with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined: in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 (95% CI: 0.0159-0.322); gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 (9$% CI: -0.0866-0.198); and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 (9S% CI: 0.137-0.415). Conclusion: CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.展开更多
Marine ecosystem services are the benefits which people obtain from the marine ecosystem,including provisioning services,regulating services,cultural services and supporting services. The human species,while buffered ...Marine ecosystem services are the benefits which people obtain from the marine ecosystem,including provisioning services,regulating services,cultural services and supporting services. The human species,while buffered against environmental changes by culture and technology,is fundamentally dependent on the flow of ecosystem services. Marine ecosystem services become increasingly valuable as the terrestrial resources become scarce. The value of marine ecosystem services is the monetary flow of ecosystem services on specific temporal and spatial scales,which often changes due to the variation of the goods prices,yields and the status of marine exploitation. Sensitivity analysis is to study the relationship between the value of marine ecosystem services and the main factors which affect it. Uncertainty analysis based on varying prices,yields and status of marine exploitation was carried out. Through uncertainty analysis,a more credible value range instead of a fixed value of marine ecosystem services was obtained in this study. Moreover,sensitivity analysis of the marine ecosystem services value revealed the relative importance of different factors.展开更多
Disassembly and recycling of E-waste creates a series of environmental problems. The selection of a technologically reliable, environmentally friendly, economically affordable and socially acceptable recycling technol...Disassembly and recycling of E-waste creates a series of environmental problems. The selection of a technologically reliable, environmentally friendly, economically affordable and socially acceptable recycling technology for E-waste is a significant question. This study establishes a Monte-Carlo mathematical model of cost minimization, given the constraints of environmentally sound handling of the e-waste, in the context of Crystal Ball risk assessment and evaluation software. By following the streams of the different treatment processes, which consist of various technologies including disassembly, recycling and disposal, the econom-ics of various possibilities were identified and the optimal recycling technology proposed. The key factors of the proposed scenarios were determined by using sensitivity analysis. The results of this study show that, for discarded refrigerators, the operating life span plays the key role. The model supports maintenance and resale of the short lived refrigerators. For the longer lived refrigerators material recycling is recommended by the model. Sensitivity analysis shows that purchase cost, plastic sale price, condenser sale price and disassembly costs are the main effects. This study provides a significant technical support for policy making in E-waste management.展开更多
To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysi...To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysis of BTRRC was accomplished from a probabilistic prospective by considering nonlinear material attributes and dynamic loads. Firstly, multiply response surface model(MRSM) was proposed and the mathematical model of this method was established based on quadratic function. Secondly, the BTRRC was decomposed into three sub-components(turbine disk, blade and casing), and then the single response surface functions(SRSFs) of three structures were built in line with the basic idea of MRSM. Thirdly, the response surface function(MRSM) of BTRRC was reshaped by coordinating SRSFs. From the analysis, it is acquired to probabilistic distribution characteristics of input-output variables, failure probabilities of blade-tip clearance under different static blade-tip clearances δ and major factors impacting BTRRC. Considering the reliability and efficiency of gas turbine, δ=1.87 mm is an optimally acceptable option for rational BTRRC. Through the comparison of three analysis methods(Monte Carlo method, traditional response surface method and MRSM), the results show that MRSM has higher accuracy and higher efficiency in reliability sensitivity analysis of BTRRC. These strengths are likely to become more prominent with the increasing times of simulations. The present study offers an effective and promising approach for reliability sensitivity analysis and optimal design of complex dynamic assembly relationship.展开更多
In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and t...In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and the assumptions of Langmuir isotherms and axial dispersion controlled mass transfer process were confirmed. The axial dispersion coefficient in Ca(Ⅱ)-CS microspheres packed column was found to be almost proportional to the linear velocity and fit for prediction through single breakthrough test. Sensitivity analysis for breakthrough curve indicated the axial dispersion coefficient as well as Langmuir coefficient was sensitive variable for deep removal requirement. The retrieval of the adsorption isotherms of Ca(Ⅱ)-CS microspheres from breakthrough curve was fulfilled by modelling calibration. A strategy based on the correlation between adsorption isotherms and breakthrough performance was further proposed to simplify the column adsorption design using absorbents with small/uniform size and fast adsorption kinetics like Ca(Ⅱ)-CS microspheres to cut down the gap between lab and industry.展开更多
In a social network analysis the output provided includes many measures and metrics. For each of these measures and metric, the output provides the ability to obtain a rank ordering of the nodes in terms of these meas...In a social network analysis the output provided includes many measures and metrics. For each of these measures and metric, the output provides the ability to obtain a rank ordering of the nodes in terms of these measures. We might use this information in decision making concerning disrupting or deceiving a given network. All is fine when all the measures indicate the same node as the key or influential node. What happens when the measures indicate different key nodes? Our goal in this paper is to explore two methodologies to identify the key players or nodes in a given network. We apply TOPSIS to analyze these outputs to find the most influential nodes as a function of the decision makers' inputs as a process to consider both subjective and objectives inputs through pairwise comparison matrices. We illustrate our results using two common networks from the literature: the Kite network and the Information flow network from Knoke and Wood. We discuss some basic sensitivity analysis can may be applied to the methods. We find the use of TOPSIS as a flexible method to weight the criterion based upon the decision makers' inputs or the topology of the network.展开更多
This study establishes the launch dynamics method,sensitivity analysis method,and multiobjective dynamic optimization method for the dynamic simulation analysis of the multiple launch rocket system(MLRS)based on the R...This study establishes the launch dynamics method,sensitivity analysis method,and multiobjective dynamic optimization method for the dynamic simulation analysis of the multiple launch rocket system(MLRS)based on the Riccati transfer matrix method for multibody systems(RMSTMM),direct differentiation method(DDM),and genetic algorithm(GA),respectively.Results show that simulation results of the dynamic response agree well with test results.The sensitivity analysis method is highly programming,the matrix order is low,and the calculation time is much shorter than that of the Lagrange method.With the increase of system complexity,the advantage of a high computing speed becomes more evident.Structural parameters that have the greatest influence on the dynamic response include the connection stiffness between the pitching body and the rotating body,the connection stiffness between the rotating body and the vehicle body,and the connection stiffnesses among 14^(#),16^(#),and 17^(#)wheels and the ground,which are the optimization design variables.After optimization,angular velocity variances of the pitching body in the revolving and pitching directions are reduced by 97.84%and 95.22%,respectively.展开更多
Although mathematical models(e.g., De Nitrification and De Composition(DNDC) provide a powerful tool to study regional carbon budget, it is still difficult to obtain accurate simulation results because there exists la...Although mathematical models(e.g., De Nitrification and De Composition(DNDC) provide a powerful tool to study regional carbon budget, it is still difficult to obtain accurate simulation results because there exists large uncertainties in modeling regional carbon budget. Through the investigation on the sensitivity of model output parameters to the input parameters, sensitivity analysis(SA) has been proved to be able to identify the key sources of uncertainties and be helpful to reduce the model uncertainties. However, some input parameters with discrete values(e.g., land use type and soil type) and the regional effect of the sensitive parameters were rarely examined in SA. In this paper, taking the Zoige Plateau as a case area, we combined the one-factor-ata-time(OAT) with Extended Fourier Amplitude Sensitivity Test(EFAST) to conduct a SA of DNDC for simulating the regional carbon budget, including Gross Primary Productivity(GPP), Net Primary Productivity(NPP), Net Ecosystem Productivity(NEP), autotrophic respiration(Ra), soil microbial heterotrophic respiration(Rh) and ecosystem respiration(Re). The result showed that the combination of OAT and EFAST could test the contribution of the input parameters with discrete values to the output parameters. In DNDC model, land use type and soil type had a significant impact on the regional carbon budget of the Zoige Plateau, and daily temperature was also confirmed to be one of the most important parameters for carbon budget. For the other input parameters, with the change of land use type or soil type at regional scale, the sensitive parameters of carbon budget would vary accordingly. The SA results would provide scientific evidence to optimize DNDC model and they suggested that we should pay attention to the spatial/temporal effect of SA and try to use the appropriate data in simulation of the regional carbon budget.展开更多
One of the most serious conundrum facing the stope production in underground metalliferous mining is uneven break (UB: unplanned dilution and ore-loss). Although the UB has a huge economic fallout to the entire min...One of the most serious conundrum facing the stope production in underground metalliferous mining is uneven break (UB: unplanned dilution and ore-loss). Although the UB has a huge economic fallout to the entire mining process, it is practically unavoidable due to the complex causing mechanism. In this study, the contribution of ten major UB causative parameters ha,; been scrutinised based on a published UB predicting artificial neuron network (ANN) model to put UB under the engineering management. Two typical ANN sensitivity analysis methods, i.e., connection weight algorithm (CWA) and profile method (PM) have been applied. As a result of CWA and PM applications, adjusted Qrate (AQ) revealed as the most influential parameter to UB with contribution of 22,40% in CWA and 20,48% in PM respectively. The findings of this study can be used as an important reference in stope design, production, and reconciliation stages on underground stoping mine.展开更多
基金National Natural Science Foundation of China(52307127)State Key Laboratory of Power System Operation and Control(SKLD23KZ07)。
文摘To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current(MMC-HVDC)systems and streamline the simulation process for determining MMC impedance characteristics,a simplified mathematical simulation model for MMC closed-loop impedance is developed using the harmonic state space method.This model considers various control strategies and includes both AC-side and DC-side impedance models.By applying a Nyquist criterion-based impedance analysis method,the stability mechanisms on the AC and DC sides of the MMC are examined.In addition,a data-driven oscillation stability analysis method is also proposed,leveraging a global sensitivity algorithm based on fast model results to identify key parameters influencing MMC oscillation stability.Based on sensitivity analysis results,a parameter adjustment strategy for oscillation suppression is proposed.The simulation results from the MATLAB/Simulinkbased MMC model validate the effectiveness of the proposed method.
文摘Although the genetic algorithm (GA) has very powerful robustness and fitness, it needs a large size of population and a large number of iterations to reach the optimum result. Especially when GA is used in complex structural optimization problems, if the structural reanalysis technique is not adopted, the more the number of finite element analysis (FEA) is, the more the consuming time is. In the conventional structural optimization the number of FEA can be reduced by the structural reanalysis technique based on the approximation techniques and sensitivity analysis. With these techniques, this paper provides a new approximation model-segment approximation model, adopted for the GA application. This segment approximation model can decrease the number of FEA and increase the convergence rate of GA. So it can apparently decrease the computation time of GA. Two examples demonstrate the availability of the new segment approximation model.
文摘For a detector in a capacitanee fuze working in an electrostatic field, the bomblength (effective length of the conductor part) is an important factor affecting the sensitivityof detection. For the two different kinds of detecting circuit models in general use (the frequency-sensitive and the amplitude-coupling ), mechanism of the effect of bomblength on the sensitvity of detection is analyzed. Through the analysis a conclusion in fullagreement with experimental results has been drawn, that is. the longer the bomb length,the higher the sensitivity, on the condition that the sizes and the sites of the detecting electrodes and bomb diameter remain unchanged.
基金jointly sponsored by the National Natural Science Foundation of China(Grant No.40830955)the China Meteorological Administration(Grant No.GYHY200906009)
文摘This study investigated the influence of dropwindsonde observations on typhoon forecasts. The study also evaluated the feasibility of the conditional nonlinear optimal perturbation (CNOP) method as a basis for sensitivity analysis of such forecasts. This sensitivity analysis could furnish guidance in the selection of targeted observations. The study was performed by conducting observation system experiments (OSEs). This research used the fifth-generation Mesoscale Model (MM5), the Weather Research and Forecasting (WRF) model, and dropsonde observations of Typhoon Nida at 1200 UTC 17 May 2004. The dropsondes were collected under the operational Dropsonde Observations for Typhoon Surveillance near the Taiwan Region (DOTSTAR) program. In this research, five kinds of experiments were designed and conducted:(1) no observations were assimilated; (2) all observations were assimilated;(3) observations in the sensitive area revealed by the CNOP method were assimilated;(4) the same as in (3), but for the region revealed by the first singular vector (FSV) method;and (5) observations within a randomly selected area were assimilated. The OSEs showed that (1) the DOTSTAR data had a positive impact on the forecast of Nida's track;(2) dropsondes in the sensitive areas identified by the MM5 CNOP and FSV remained effective for improving the track forecast for Nida on the WRF platform;and (3) the greatest improvement in the track forecast resulted from the CNOP-based (third) simulation, which indicated that the CNOP method would be useful in decision making about dropsonde deployments.
文摘AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le.
基金Project(51178345) supported by the National Natural Science Foundation of ChinaProject(2011AA110305) supported by the National High Technology Research and Development Program of ChinaProject supported by the Program for Young Excellent Talents in Tongji University, China
文摘A signal optimization model for roundabout was control concept were used to eliminate the conflict points proposed based on dual-ring scheme and two stop lines for left turns and weaving sections at a roundabout. A cycle length minimization problem was considered to generate optimal signal timings for roundabout, and a set of constraints to ensure feasibility and safety of the resulting optimal signal settings were proposed. Extensive experimental analyses in comparison with signalized intersection reveal that the proposed model is quite promising for application in design of roundabout signals, and the minimum cycle length can decrease from 186 s to 79 s while the capacity increases from 8 682 pcu/h to 9 011 pcu/h under high demand scenario. Sensitivity analysis with respect to the system performance show that the lane assignment plan, number of circulatory lanes and left turn ratio are three critical factors which have dominate impacts on performance of signalized roundabout
基金Projects(51375032,51175017,51245027)supported by the National Natural Science Foundation of China
文摘In order to describe and control the stress distribution and total deformation of bladed disk assemblies used in the aeroengine, a highly efficient and precise method of probabilistic analysis which is called extremum response surface method(ERSM) is produced based on the previous deterministic analysis results with the finite element model(FEM). In this work, many key nonlinear factors, such as the dynamic feature of the temperature load, the centrifugal force and the boundary conditions, are taken into consideration for the model. The changing patterns with time of bladed disk assemblies about stress distribution and total deformation are obtained during the deterministic analysis, and at the same time, the largest deformation and stress nodes of bladed disk assemblies are found and taken as input target of probabilistic analysis in a scientific and reasonable way. Not only their reliability, historical sample, extreme response surface(ERS) and the cumulative probability distribution function but also their sensitivity and effect probability are obtained. Main factors affecting stress distribution and total deformation of bladed disk assemblies are investigated through the sensitivity analysis of the model. Finally, compared with the response surface method(RSM) and the Monte Carlo simulation(MCS), the results show that this new approach is effective.
基金Project 1053G032 supported by the Youth Science Foundation of Educational Committee of Heilongjiang Province
文摘Monitoring the stability of steep slopes of open-pit mines is a major issue relating to production safety in mines.In order to determine the technical parameters of a new type of supervising system applied in monitoring steep slopes of open-pit mines,the MSARMA method was used to establish analytical models for the monitoring system,given various parameter settings based on the description of mechanical monitoring principles.We used this sensitivity analysis to conclude that the setting of the most sensitive location of a mechanical monitoring system should be within a range of 1/5~1/2 of the lower part in a vertical direction of steep slopes,with a rational and feasible range of the dip angle setting between 0°~20°.Given the analytical results of our on-site experiments,we have shown that the parameters determined reflect the stability of steep slopes accurately and effectively.These conclusions provide a basis for the application of a new type of steep slope stability monitoring technology in open-pit mines.
基金Project(51108343)supported by the National Natural Science Foundation of ChinaProject(06121)supported by University of Transportation Center for Alabama,USA
文摘A novel conditional cell transmission model (CCTM) is a potential simulation tool because it accommodates all traffic conditions from light condition to oversaturated condition. To test the performance of the CCTM, a series of experiments for sensitivity analysis were designed and performed for a multilane, two-way, three-signal sample network. Experiment 1 shows that the model is performed in a logical and expected manner with variations in traffic demand with time and direction. Experiment 2 shows when the possibility of the occurrence of a useful gap increases to 60% and 100%, the delays in left rams decrease by 5% and 15%, respectively. In Experiment 3, comparing the possibility of a conditional cell of 0 with 100%, delay of left turn and delay of the entire network were underestimated by 58% and 11%, respectively. Hence, sensitivity analysis demonstrates that by reflecting local drivers' behaviors properly, the CCTM provides an accurate representation of traffic flow in simulating oversaturated traffic conditions.
文摘A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a mine, operators need to know the cause and effect of any changes requested from the VOD system. The sensitivity analysis is developed through generating a cause and effect matrix of sensitivity factors on given parameter changes in a ventilation system. This new utility, which was incorporated in the 3D-CANVENT mine ventilation simulator, is able to predict the airflow distributions in a ventilation network when underground conditions and ventilation controls are changed. For a primary ventilation system, the software can determine the optimal operating speed of the main fans to satisfy the airflow requirements in underground workings without necessarily using booster fans and regulators locally. An optimized fan operating speed time-table would assure variable demand-based fresh air delivery to the production areas effectively, while generating significant savings in energy consumption and operating cost.
基金the financial support provided by the Biotechnology Information Service–Sub-Distributed Information Centre(supported by the Department of Biotechnology,Government of India)Advanced Bioinformatics Centre(supported by the Government of Rajasthan)at Birla Institute of Scientific Research for the infrastructure and facilities for conducting statistical work
文摘Objective: To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods: The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted. Results: Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined: in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 (SE=0.0S), with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 (SE=0.04), with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated: in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 (SE=0.05), with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 (SE=0.05), with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 (SE=0.05), with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined: in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 (95% CI: 0.0159-0.322); gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 (9$% CI: -0.0866-0.198); and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 (9S% CI: 0.137-0.415). Conclusion: CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.
基金funded by the Marine Public Welfare Pro-ject of China (Nos. 200705029, 200805080)the National Basic Research Program of China (No. 2002CB412406)SOA-funded Program (No. 908-02-04-03)
文摘Marine ecosystem services are the benefits which people obtain from the marine ecosystem,including provisioning services,regulating services,cultural services and supporting services. The human species,while buffered against environmental changes by culture and technology,is fundamentally dependent on the flow of ecosystem services. Marine ecosystem services become increasingly valuable as the terrestrial resources become scarce. The value of marine ecosystem services is the monetary flow of ecosystem services on specific temporal and spatial scales,which often changes due to the variation of the goods prices,yields and the status of marine exploitation. Sensitivity analysis is to study the relationship between the value of marine ecosystem services and the main factors which affect it. Uncertainty analysis based on varying prices,yields and status of marine exploitation was carried out. Through uncertainty analysis,a more credible value range instead of a fixed value of marine ecosystem services was obtained in this study. Moreover,sensitivity analysis of the marine ecosystem services value revealed the relative importance of different factors.
基金Projects 50574094 supported by the National Natural Science Foundation of ChinaCPEUKF06-11 by the Key Laboratory Open Project of Education Ministry of China200600242 by the Science and Technology Innovation Project of Xuzhou
文摘Disassembly and recycling of E-waste creates a series of environmental problems. The selection of a technologically reliable, environmentally friendly, economically affordable and socially acceptable recycling technology for E-waste is a significant question. This study establishes a Monte-Carlo mathematical model of cost minimization, given the constraints of environmentally sound handling of the e-waste, in the context of Crystal Ball risk assessment and evaluation software. By following the streams of the different treatment processes, which consist of various technologies including disassembly, recycling and disposal, the econom-ics of various possibilities were identified and the optimal recycling technology proposed. The key factors of the proposed scenarios were determined by using sensitivity analysis. The results of this study show that, for discarded refrigerators, the operating life span plays the key role. The model supports maintenance and resale of the short lived refrigerators. For the longer lived refrigerators material recycling is recommended by the model. Sensitivity analysis shows that purchase cost, plastic sale price, condenser sale price and disassembly costs are the main effects. This study provides a significant technical support for policy making in E-waste management.
基金Projects(51175017,51245027)supported by the National Natural Science Foundation of China
文摘To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysis of BTRRC was accomplished from a probabilistic prospective by considering nonlinear material attributes and dynamic loads. Firstly, multiply response surface model(MRSM) was proposed and the mathematical model of this method was established based on quadratic function. Secondly, the BTRRC was decomposed into three sub-components(turbine disk, blade and casing), and then the single response surface functions(SRSFs) of three structures were built in line with the basic idea of MRSM. Thirdly, the response surface function(MRSM) of BTRRC was reshaped by coordinating SRSFs. From the analysis, it is acquired to probabilistic distribution characteristics of input-output variables, failure probabilities of blade-tip clearance under different static blade-tip clearances δ and major factors impacting BTRRC. Considering the reliability and efficiency of gas turbine, δ=1.87 mm is an optimally acceptable option for rational BTRRC. Through the comparison of three analysis methods(Monte Carlo method, traditional response surface method and MRSM), the results show that MRSM has higher accuracy and higher efficiency in reliability sensitivity analysis of BTRRC. These strengths are likely to become more prominent with the increasing times of simulations. The present study offers an effective and promising approach for reliability sensitivity analysis and optimal design of complex dynamic assembly relationship.
基金the National Natural Science Foundation of China(2117613621422603)the National Science and Technology Support Program of China(2011BAC06B01)
文摘In this work, an equilibrium-dispersion model was successfully established to describe the breakthrough performance of Ca(Ⅱ) imprinted chitosan (Ca(Ⅱ)-CS) microspheres packed column for metal adsorption, and the assumptions of Langmuir isotherms and axial dispersion controlled mass transfer process were confirmed. The axial dispersion coefficient in Ca(Ⅱ)-CS microspheres packed column was found to be almost proportional to the linear velocity and fit for prediction through single breakthrough test. Sensitivity analysis for breakthrough curve indicated the axial dispersion coefficient as well as Langmuir coefficient was sensitive variable for deep removal requirement. The retrieval of the adsorption isotherms of Ca(Ⅱ)-CS microspheres from breakthrough curve was fulfilled by modelling calibration. A strategy based on the correlation between adsorption isotherms and breakthrough performance was further proposed to simplify the column adsorption design using absorbents with small/uniform size and fast adsorption kinetics like Ca(Ⅱ)-CS microspheres to cut down the gap between lab and industry.
文摘In a social network analysis the output provided includes many measures and metrics. For each of these measures and metric, the output provides the ability to obtain a rank ordering of the nodes in terms of these measures. We might use this information in decision making concerning disrupting or deceiving a given network. All is fine when all the measures indicate the same node as the key or influential node. What happens when the measures indicate different key nodes? Our goal in this paper is to explore two methodologies to identify the key players or nodes in a given network. We apply TOPSIS to analyze these outputs to find the most influential nodes as a function of the decision makers' inputs as a process to consider both subjective and objectives inputs through pairwise comparison matrices. We illustrate our results using two common networks from the literature: the Kite network and the Information flow network from Knoke and Wood. We discuss some basic sensitivity analysis can may be applied to the methods. We find the use of TOPSIS as a flexible method to weight the criterion based upon the decision makers' inputs or the topology of the network.
基金The Natural Science Foundation of China(No.11972193)the Science Challenge Project(No.TZ2016006-0104)。
文摘This study establishes the launch dynamics method,sensitivity analysis method,and multiobjective dynamic optimization method for the dynamic simulation analysis of the multiple launch rocket system(MLRS)based on the Riccati transfer matrix method for multibody systems(RMSTMM),direct differentiation method(DDM),and genetic algorithm(GA),respectively.Results show that simulation results of the dynamic response agree well with test results.The sensitivity analysis method is highly programming,the matrix order is low,and the calculation time is much shorter than that of the Lagrange method.With the increase of system complexity,the advantage of a high computing speed becomes more evident.Structural parameters that have the greatest influence on the dynamic response include the connection stiffness between the pitching body and the rotating body,the connection stiffness between the rotating body and the vehicle body,and the connection stiffnesses among 14^(#),16^(#),and 17^(#)wheels and the ground,which are the optimization design variables.After optimization,angular velocity variances of the pitching body in the revolving and pitching directions are reduced by 97.84%and 95.22%,respectively.
基金financial support from National Natural Science Foundation of China(Grants No.41271433,41571373,41301385)the International Cooperation Key Project of CAS(Grant No.GJHZ201320)+3 种基金the International Cooperation Partner Program of Innovative Team,CAS(Grant No.KZZD-EW-TZ-06)STS-Network Plan,CAS(KFJ-EW-STS-020-02)the Strategic Leader Science and Technology project(XDA05050105)“Hundred Talents”Project of Chinese Academy of Sciences
文摘Although mathematical models(e.g., De Nitrification and De Composition(DNDC) provide a powerful tool to study regional carbon budget, it is still difficult to obtain accurate simulation results because there exists large uncertainties in modeling regional carbon budget. Through the investigation on the sensitivity of model output parameters to the input parameters, sensitivity analysis(SA) has been proved to be able to identify the key sources of uncertainties and be helpful to reduce the model uncertainties. However, some input parameters with discrete values(e.g., land use type and soil type) and the regional effect of the sensitive parameters were rarely examined in SA. In this paper, taking the Zoige Plateau as a case area, we combined the one-factor-ata-time(OAT) with Extended Fourier Amplitude Sensitivity Test(EFAST) to conduct a SA of DNDC for simulating the regional carbon budget, including Gross Primary Productivity(GPP), Net Primary Productivity(NPP), Net Ecosystem Productivity(NEP), autotrophic respiration(Ra), soil microbial heterotrophic respiration(Rh) and ecosystem respiration(Re). The result showed that the combination of OAT and EFAST could test the contribution of the input parameters with discrete values to the output parameters. In DNDC model, land use type and soil type had a significant impact on the regional carbon budget of the Zoige Plateau, and daily temperature was also confirmed to be one of the most important parameters for carbon budget. For the other input parameters, with the change of land use type or soil type at regional scale, the sensitive parameters of carbon budget would vary accordingly. The SA results would provide scientific evidence to optimize DNDC model and they suggested that we should pay attention to the spatial/temporal effect of SA and try to use the appropriate data in simulation of the regional carbon budget.
文摘One of the most serious conundrum facing the stope production in underground metalliferous mining is uneven break (UB: unplanned dilution and ore-loss). Although the UB has a huge economic fallout to the entire mining process, it is practically unavoidable due to the complex causing mechanism. In this study, the contribution of ten major UB causative parameters ha,; been scrutinised based on a published UB predicting artificial neuron network (ANN) model to put UB under the engineering management. Two typical ANN sensitivity analysis methods, i.e., connection weight algorithm (CWA) and profile method (PM) have been applied. As a result of CWA and PM applications, adjusted Qrate (AQ) revealed as the most influential parameter to UB with contribution of 22,40% in CWA and 20,48% in PM respectively. The findings of this study can be used as an important reference in stope design, production, and reconciliation stages on underground stoping mine.