We present three cases of autoimmune pancreatitis(AIP) complicated by gastric varices.Case 1:A 57-yearold man was diagnosed with AIP complicated by gastric varices and splenic vein obstruction.Splenomegaly was not det...We present three cases of autoimmune pancreatitis(AIP) complicated by gastric varices.Case 1:A 57-yearold man was diagnosed with AIP complicated by gastric varices and splenic vein obstruction.Splenomegaly was not detected at the time of the diagnosis.The AIP improved using steroid therapy,the splenic vein was reperfused,and the gastric varices disappeared;case 2:A 55-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.Although the AIP improved using steroid therapy,the gastric varices and splenic vein obstruction did not resolve;case 3:A 68-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.The gastric varices,splenic vein obstruction,and AIP did not improve using steroid therapy.These three cases suggest that gastric varices or splenic vein obstruction without splenomegaly may be an indication for steroid therapy in patients with AIP because the complications will likely become irreversible over time.展开更多
AIM: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).METHODS: Changes of pathological signs and histological grading of 106 patients with active UC were observed...AIM: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).METHODS: Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.RESULTS: The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC (P〈0.001) and 68% and 26.7% in the moderate active UC (P〈0.001) before and after treatment, Fibroid necrosis of vessel wail was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment, No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment, The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC (P〈0.05), and 42% and 40% in moderate UC (P〉0.05) before and after treatment, The rate of eosinophil infiltration was 98.2% and 80,4% in mild UC (P〈0.01),and 100% and 91,1% in moderate UC (P〈0.05) before and after treatment, The effect on crypt abscess was 21.4% and 4.4% in mild UC (P〈0.05), and 48% and 13.3% in moderate UC (P〈0.001) before and after treatment. The effect on mucosal pathohistological grading was 2.00±0.84 and 0.91±0.46 in mild UC (P〈0.001), and 2.49±0.84 and 1.31±0.75 in moderate UC (P〈0.001) before and after treatment.CONCLUSION: SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC.展开更多
This is a case report of a patient who presented with acute pancreatitis without the common causes. A pancreatic biopsy revealed large B cell lymphoma. Spleen lymphoma with pancreatic involvement inducing acute pancre...This is a case report of a patient who presented with acute pancreatitis without the common causes. A pancreatic biopsy revealed large B cell lymphoma. Spleen lymphoma with pancreatic involvement inducing acute pancreatitis, which is a rare disorder, was diagnosed. Here we also review the few similar cases reported in the literature.展开更多
文摘We present three cases of autoimmune pancreatitis(AIP) complicated by gastric varices.Case 1:A 57-yearold man was diagnosed with AIP complicated by gastric varices and splenic vein obstruction.Splenomegaly was not detected at the time of the diagnosis.The AIP improved using steroid therapy,the splenic vein was reperfused,and the gastric varices disappeared;case 2:A 55-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.Although the AIP improved using steroid therapy,the gastric varices and splenic vein obstruction did not resolve;case 3:A 68-year-old man was diagnosed with AIP complicated by gastric varices,splenic vein obstruction,and splenomegaly.The gastric varices,splenic vein obstruction,and AIP did not improve using steroid therapy.These three cases suggest that gastric varices or splenic vein obstruction without splenomegaly may be an indication for steroid therapy in patients with AIP because the complications will likely become irreversible over time.
文摘AIM: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).METHODS: Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.RESULTS: The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC (P〈0.001) and 68% and 26.7% in the moderate active UC (P〈0.001) before and after treatment, Fibroid necrosis of vessel wail was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment, No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment, The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC (P〈0.05), and 42% and 40% in moderate UC (P〉0.05) before and after treatment, The rate of eosinophil infiltration was 98.2% and 80,4% in mild UC (P〈0.01),and 100% and 91,1% in moderate UC (P〈0.05) before and after treatment, The effect on crypt abscess was 21.4% and 4.4% in mild UC (P〈0.05), and 48% and 13.3% in moderate UC (P〈0.001) before and after treatment. The effect on mucosal pathohistological grading was 2.00±0.84 and 0.91±0.46 in mild UC (P〈0.001), and 2.49±0.84 and 1.31±0.75 in moderate UC (P〈0.001) before and after treatment.CONCLUSION: SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC.
文摘This is a case report of a patient who presented with acute pancreatitis without the common causes. A pancreatic biopsy revealed large B cell lymphoma. Spleen lymphoma with pancreatic involvement inducing acute pancreatitis, which is a rare disorder, was diagnosed. Here we also review the few similar cases reported in the literature.