接头分子在Toll样受体(Toll like receptors,TLRs)识别病原相关分子模式或损伤相关分子模式、发动和调节先天与后天免疫反应的信号传导网络中发挥着重要的生物学作用,与Toll样受体相结合后,其下游激酶和转录因子传导信号,激活细胞内核...接头分子在Toll样受体(Toll like receptors,TLRs)识别病原相关分子模式或损伤相关分子模式、发动和调节先天与后天免疫反应的信号传导网络中发挥着重要的生物学作用,与Toll样受体相结合后,其下游激酶和转录因子传导信号,激活细胞内核转录因子调控作用元件。TLRs接头分子的共同特征是含有TIR结构域,不同TLRs家族成员可依赖于一个或多个接头分子传导信号。对目前已确认的MyD88、MAL/TIRAP、TRIF、TRAM和SARM 5种接头分子在TLRs信号传导途径中的调控作用进行综述,以期为研究接头分子在TLRs信号传导中的作用机制提供参考。展开更多
Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and dec...Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, result- ing in formation of severe tissue edema, hypotension or even shock, especially in severe burn injury. Fluid resusci- tation has been the only valid approach to sustain patient＇s blood volume for a long time, due to the lack of overall and profound understanding of the mechanisms of vascular hyperpermeability response. There is an emerging concept in recent years that some so-called barrier stabilizing media- tors play a positive role in preventing the increase ofvascu-lar permeability. These mediators may be released in re- sponse to proinflammatory mediators and serve to restore endothelial barrier function. Some of these stabilizing mediators are important even in quiescent state because they preserve basal vascular permeability at low levels. This review introduces some of these mediators and reveals their underlying signaling mechanisms during endothelial barrier enhancing process.展开更多
文摘接头分子在Toll样受体(Toll like receptors,TLRs)识别病原相关分子模式或损伤相关分子模式、发动和调节先天与后天免疫反应的信号传导网络中发挥着重要的生物学作用,与Toll样受体相结合后,其下游激酶和转录因子传导信号,激活细胞内核转录因子调控作用元件。TLRs接头分子的共同特征是含有TIR结构域,不同TLRs家族成员可依赖于一个或多个接头分子传导信号。对目前已确认的MyD88、MAL/TIRAP、TRIF、TRAM和SARM 5种接头分子在TLRs信号传导途径中的调控作用进行综述,以期为研究接头分子在TLRs信号传导中的作用机制提供参考。
基金The study was supported by General Program from Natural Science Foundation of China （Nos. 30971201 and 81170297）, Program for Changjiang Scholars and Innovative Research Team in University （No. IRT0731）, and National Key Foundation for Basic Science Research of China （No. G2005CB522601）.
文摘Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, result- ing in formation of severe tissue edema, hypotension or even shock, especially in severe burn injury. Fluid resusci- tation has been the only valid approach to sustain patient＇s blood volume for a long time, due to the lack of overall and profound understanding of the mechanisms of vascular hyperpermeability response. There is an emerging concept in recent years that some so-called barrier stabilizing media- tors play a positive role in preventing the increase ofvascu-lar permeability. These mediators may be released in re- sponse to proinflammatory mediators and serve to restore endothelial barrier function. Some of these stabilizing mediators are important even in quiescent state because they preserve basal vascular permeability at low levels. This review introduces some of these mediators and reveals their underlying signaling mechanisms during endothelial barrier enhancing process.
