炎症生化指标与宫颈癌临床病理特征的关系探讨

目的探讨炎症生化指标与宫颈癌临床病理特征之间的关系,辅助临床评估宫颈癌疾病进展与预后。方法选取2018年6月~2022年7月在华北理工大学附属医院及唐山市妇幼保健院行宫颈癌手术的216例患者为研究对象,记录术前1周内最近一次中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、C反应蛋白(CRP)、D-二聚体(D-D)、纤维蛋白原(FIB)、糖类抗原125(CA125)结果,以宫颈癌病理类型、病理分期、分化程度、有无淋巴结转移分组,采用t检验和F检验分析以上生化指标与宫颈癌临床病理特征之间的相关性。结果上述指标在不同病理类型分组中差异均无统计学意义(P>0.05);NLR、PLR、CRP、D-D、FIB、CA125在宫颈癌不同病理分期(I-III期)、有无淋巴转移的患者中差异均有统计学意义(P<0.05);NLR、D-D、FIB、CA125在不同分化程度(高、中、低)患者中比较,差异均有统计学意义(P<0.05)。结论NLR、PLR、CRP、D-D、FIB、CA125与宫颈癌临床病理特征具有一定相关性,可作为辅助临床评估宫颈癌疾病进展与预后的重要指标。

Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?

AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile duct.METHODS:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary enzymes.These symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on MRCP.All these patients were subjected to ERCP within 3 d of MRCP to check for the presence of stones.RESULTS:No stones were detected by ERCP in any patient,confi rming the results of MRCP.CONCLUSION:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary.