有机相中利用脂肪酶催化的醇解反应拆分炔丙醇酮乙酸酯

研究了有机相中脂肪酶催化的炔丙醇酮乙酸酯的立体选择性醇解反应,考察了碱的种类、酰基受体和溶剂等对反应的影响.结果表明,以四氢呋喃为溶剂,CH3OH为酰基受体,Lipase PLG脂肪酶为催化剂,Na2CO3为碱性添加剂,高底物浓度下40oC反应96h后,底物转化率和产物ee值分别达到49.5%和99.5%.碱的添加极大地提高了反应速度.

Rhodium(Ⅲ)-catalyzed selective access to isoindolinones via formal [4+1] annulation of arylamides and propargyl alcohols

A mild and efficient oxidative synthesis of isoindolinones has been realized by Rh(III)‐catalyzed C?H activation of benzamides and[4+1]coupling with propargyl alcohols.This coupling system proceeds with broad substrate scope and mild conditions and provides a new approach to access the useful skeleton ofγ‐lactams with a stereogenic center.

Synthesis of α-hydroxy ketones by copper（Ⅰ）-catalyzed hydration of propargylic alcohols: CO2 as a cocatalyst under atmospheric pressure

Inexpensive and efficient Cu(Ⅰ) catalysis is reported for the synthesis of α-hydroxy ketones from propargylic alcohols, CO2, and water via tandem carboxylative cyclization and nucleophilic addition reaction. Notably, hydration of propargylic alcohols can be carried out smoothly under atmospheric CO2 pressure, generating a series of α-hydroxy ketones efficiently and selectively. This strategy shows great potential for the preparation of valuable α-hydroxy ketones by using CO2 as a crucial cocatalyst under mild conditions.