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基于实验数据计算机仿真大鼠视神经纤维对于胞外点电极刺激的响应与影响 被引量:3
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作者 高洁 乔清理 解楠 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2010年第9期1629-1633,共5页
背景:目前的视觉假体有3种,即视网膜假体,视神经假体和视觉皮质假体,保证视神经纤维的正常是使用视神经假体的基础。对于有髓视神经纤维的胞外刺激实际上是胞内刺激的延续和发展,与胞内刺激相比,胞外刺激的优势在于刺激位置的选择更加灵... 背景:目前的视觉假体有3种,即视网膜假体,视神经假体和视觉皮质假体,保证视神经纤维的正常是使用视神经假体的基础。对于有髓视神经纤维的胞外刺激实际上是胞内刺激的延续和发展,与胞内刺激相比,胞外刺激的优势在于刺激位置的选择更加灵活,操作上的精确度要求相对较低。目的:通过计算机来仿真大鼠视神经纤维对于胞外点电极源刺激的响应,然后考虑电极位置对响应的影响。方法:总结大鼠视神经的实验数据和常见离子通道的特性,分析已有的类Hodgkin-Huyley视神经纤维模型;然后用计算机仿真出神经纤维模型的响应;通过改变胞外点电极源的刺激位置,比较视神经纤维各Ranvier节动作电位的变化。结果与结论:利用模型仿真说明胞外电极位置对视神经响应有影响。点电极源与视神经纤维的垂直距离越近,并且与视神经纤维中心Ranvier节点的水平距离越近,视神经纤维越容易兴奋。 展开更多
关键词 视神经纤维 点电极源 胞外电刺激 实验数据 仿真模型 数字化眼科技术
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Comparison of the time-domain electromagnetic field from an infinitesimal point charge and dipole source 被引量:3
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作者 周楠楠 薛国强 王贺元 《Applied Geophysics》 SCIE CSCD 2013年第3期349-356,359,共9页
An electromagnetic field is generated through the accelerating movement of two equal but opposite charges of a single dipole. An electromagnetic field can also be generated by a time-varying infinitesimal point charge... An electromagnetic field is generated through the accelerating movement of two equal but opposite charges of a single dipole. An electromagnetic field can also be generated by a time-varying infinitesimal point charge. In this study, a comparison between the electromagnetic fields of an infinitesimal point charge and a dipole has been presented. First, the time-domain potential function of a point source in a 3D conductive medium is derived. Then the electric and magnetic fields in a 3D homogeneous lossless space are derived via the relation between the potential and field. The field differences between the infinitesimal point charge and the dipole in the step-off time, far-source, and near-source zones are analyzed, and the accuracy of the solutions from these sources is investigated. It is also shown that the field of the infinitesimal point charge in the near-source zone is different from that of the dipole, whereas the far-source zone fields of these two sources are identical. The comparison of real and simulated data shows that the infinitesimal point charge represents the real source better than the divole source. 展开更多
关键词 Infinitesimal point charge dipole source TIME-DOMAIN electromagnetic response near-source zone.
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