Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded ta...Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded target is put forward and the non-coded and coded targets are classified. Moreover, the gray scale centroid algorithm is applied to obtain the subpixel location of both uncoded and coded targets. The initial matching of the uncoded target correspondences between an image pair is established according to similarity and compatibility, which are based on the ID correspondences of the coded targets. The outliers in the initial matching of the uncoded target are eliminated according to three rules to finally obtain the uncoded target correspondences. Practical examples show that the algorithm is rapid, robust and is of high precision and matching ratio.展开更多
Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are main...Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are mainly discussed.Based on this,the advantages of LabVIEW's interface development and Matlab's rich data operation functions are combined to achieve the fitting of explosion pressure field and dynamic compensation of temperature measured.展开更多
The self-attention networks and Transformer have dominated machine translation and natural language processing fields,and shown great potential in image vision tasks such as image classification and object detection.I...The self-attention networks and Transformer have dominated machine translation and natural language processing fields,and shown great potential in image vision tasks such as image classification and object detection.Inspired by the great progress of Transformer,we propose a novel general and robust voxel feature encoder for 3D object detection based on the traditional Transformer.We first investigate the permutation invariance of sequence data of the self-attention and apply it to point cloud processing.Then we construct a voxel feature layer based on the self-attention to adaptively learn local and robust context of a voxel according to the spatial relationship and context information exchanging between all points within the voxel.Lastly,we construct a general voxel feature learning framework with the voxel feature layer as the core for 3D object detection.The voxel feature with Transformer(VFT)can be plugged into any other voxel-based 3D object detection framework easily,and serves as the backbone for voxel feature extractor.Experiments results on the KITTI dataset demonstrate that our method achieves the state-of-the-art performance on 3D object detection.展开更多
This paper investigates the maximal achievable multi-rate throughput problem of a multicast ses-sion at the presence of network coding. Deviating from previous works which focus on single-rate network coding, our work...This paper investigates the maximal achievable multi-rate throughput problem of a multicast ses-sion at the presence of network coding. Deviating from previous works which focus on single-rate network coding, our work takes the heterogeneity of sinks into account and provides multiple data layers to address the problem. Firstly formulated is the maximal achievable throughput problem with the assumption that the data layers are independent and layer rates are static. It is proved that the problem in this case is, unfortunately, Non-deterministic Polynomial-time (NP)-hard. In addition, our formulation is extended to the problems with dependent layers and dynamic layers. Furthermore, the approximation algorithm which satisfies certain fair-ness is proposed.展开更多
We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring...We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring alnicos defined as index track and sub-division track, respectively. The index track is magnetized based on the improved gray code, with linear halls placed around the track evenly. The outputs of linear halls show the region the rotor belongs to. The sub-division track is magnetized to N-S-N-S (north-south-north-south), and the number of N-S pole pairs is determined by the index track. Three linear hall sensors with an air-gap of 2 mm are used to translate the magnetic filed to voltage signals. The relative offset in a single N-S is obtained through look-up. The magnetic encoder is calibrated using a higher-resolution incremental optical encoder. The pulse output from the optical encoder and hall signals from the magnetic encoder are sampled at the same time and transmitted to a computer, and the relation between them is calculated, and stored in the FLASH of MCU (micro controller unit) for look-up. In the working state, the absolute angle is derived by looking-up with hall signals. The structure is simple and the manufacturing cost is very low and suitable for mass production.展开更多
The positions of braiding carrier in track and column braiding are represented by a diagrammatic braiding plan and a corresponding lattice-array is defined. A set is then formed so that the permutation analysis can be...The positions of braiding carrier in track and column braiding are represented by a diagrammatic braiding plan and a corresponding lattice-array is defined. A set is then formed so that the permutation analysis can be performed to represent the movement of carriers in a braiding process. The process of 4-step braiding is analyzed as an example to describe the application of the proposed method by expressing a braiding cycle as a product of disjoint cycles. As a result, a mapping relation between the disjoint cycles and the movement of carriers is deduced. Following the same analysis principles, a process of 8-step braiding and the corresponding initial state of the lattice-array is developed. A successful permutation analysis to the process manifests the general suitability of the proposed method.展开更多
Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival rate.However,the sensitivity and specificity of the screening protocols which was widely used in clinic now a...Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival rate.However,the sensitivity and specificity of the screening protocols which was widely used in clinic now are considered to be unsatisfactory.Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) is one of the proteins that have been suggested to be a classic oncogene with transformation properties.The current study set out to discuss the clinical significance of LMP-1 on the screening of NPC.Methods: Three hundred patients who visited our institution (Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou,China) with ENT symptoms between 2007 and 2008 were involved in this study,and all of them were agreed to be involved in this investigation.Not only did they undergo nasopharyngeal swab to obtain cells for the LMP-1 polymerase chain reaction (PCR) analysis,but also nasopharyngeal biopsy were taken to identify the diagnosis.Results: An amount of DNA that was sufficient for PCR was extracted from 243 (81%) swab samples,the positive rate of LMP-1 of those with non-nasopharyngeal carcinoma was 3.85% (4/108),which was much lower than those with nasopharyngeal carcinoma (P < 0.05).By detecting LMP-1 in nasopharyngeal swabs,NPC was diagnosed with a sensitivity of 88.15% (119 of 135 patients),specificity of 96.30% (104 of 108 patients),a positive predictive value of 95.2% (119 of 123 patients),a negative predictive value of 86.67% (104 of 120 patients),accuracy of 91.77%,and Youden index of 84.45%.Conclusion: The nasopharyngeal swab coupled with PCR-based EBV LMP-1 detection have high sensitivity and specificity,and also good repeatability,it could serve as part of the screening program for high-risk populations.展开更多
Endometrial cancer (EC) is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but ...Endometrial cancer (EC) is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but it may also originate in the lower uterine segment or spread in endometrium with necrosis and hemorrhage. The analysis was performed using a custom panel containing all DNA sequences loci coding pre-miRNAs and genes related to biogenesis and regulation of sncRNAs in normal and tumor tissues extracted from 6 unrelated patients with endometrial carcinoma. The identified variations were correlated with mature miRNAs differentially expressed in the same normal and tumor endometrial tissues. The comparison analysis confirmed the high degree of cellular and genetic intratumoral heterogeneity with a temporal and spatial miRNA expression distribution in association with genomic variants identified. The classification of specific DNA mutations, onto the loci identified, should be suitable to characterize possible instability genome regions and help classification of tumors to ameliorate the clinical management of patients affected by endometrial carcinoma.展开更多
Integer overflow vulnerability will cause buffer overflow. The research on the relationship between them will help us to detect integer overflow vulnerability. We present a dynamic analysis methods RICB (Run-time Int...Integer overflow vulnerability will cause buffer overflow. The research on the relationship between them will help us to detect integer overflow vulnerability. We present a dynamic analysis methods RICB (Run-time Integer Checking via Buffer overflow). Our approach includes decompile execute file to assembly language; debug the execute file step into and step out; locate the overflow points and checking buffer overflow caused by integer overflow. We have implemented our approach in three buffer overflow types: format string overflow, stack overflow and heap overflow. Experiments results show that our approach is effective and efficient. We have detected more than 5 known integer overflow vulnerabilities via buffer overflow.展开更多
To test the reliability and stability of the inspecting program of the electronic inspection system for raw silk,a simulating program is developed to simulate various defect cases with the software tool of Laboratory ...To test the reliability and stability of the inspecting program of the electronic inspection system for raw silk,a simulating program is developed to simulate various defect cases with the software tool of Laboratory Virtual Instrument Engineering Workbench(LabVIEW).Many techniques,such as random numbers,shift registers,for loop,case structures and waveforms,are used to facilitate the simulation.The simulated defects are inspected by the inspecting program successfully,which proves the effectiveness of the simulating program.展开更多
MicroRNAs (miRNAs), which are small noncoding RNA molecules, play important roles in the post-transcriptional regulation process. The microRNA-21 gene (miR-21) has been reported to be highly expressed in various s...MicroRNAs (miRNAs), which are small noncoding RNA molecules, play important roles in the post-transcriptional regulation process. The microRNA-21 gene (miR-21) has been reported to be highly expressed in various solid tumors, including breast cancer. Bone morphogenetic protein-6 (BMP-6) has been identified as an inhibitor of breast cancer epithelial-mesenchymal transition (EMT) through rescuing E-cadherin expression. We initiated experi- ments to identify the relationships between miR-21 and BMP-6 in breast cancer progression. Real-time PCR analysis showed that miR-21 expression was very high in MDA-MB-231 cells that expressed little BMP-6. A reverse correla- tion between BMP-6 and miR-21 was also determined in breast cancer tissue samples. Moreover, BMP-6 inhibited miR-21 transcription in MDA-MB-231 cells. In order to investigate how BMP-6 inhibited the miR-21 promoter (miPPR-21), we constructed a series of miPPR-21 reporters. Luciferase assay results indicated that BMP-6 inhibited miPPR-21 activity through the E2-box and AP-l-binding sites. We also demonstrated that both δEF1 and TPA in- duced miR-21 expression. Using site-directed mutation and CHIP assay, we found that δEF1 induced miPPR-21 ac- tivity by binding to the E2-box on miPPR-21. Moreover, TPA triggered miPPR-21 activity through the AP-I binding sites. BMP-6 treatment significantly reduced the binding of these factors to miPPR-21 by decreasing the expression of δEF1 and c-Fos/c-Jun. We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activ- ity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion. δEF1 overexpression and TPA induction blocked this inhibitory effect of BMP-6. In conclusion, BMP-6-induced inhibition of miR-21 suggests that BMP-6 may function as an anti-metastasis factor by a mechanism involving transcriptional repression of miR-21 in breast cancer.展开更多
With the rapid development of 3D digital photography and 3D digital scanning devices, massive amount of point samples can be generated in acquisition of complex, real-world objects, and thus create an urgent need for ...With the rapid development of 3D digital photography and 3D digital scanning devices, massive amount of point samples can be generated in acquisition of complex, real-world objects, and thus create an urgent need for advanced point-based processing and editing. In this paper, we present an interactive method for blending point-based geometries by dragging-and- dropping one point-based model onto another model’s surface metaphor. We first calculate a blending region based on the polygon of interest when the user drags-and-drops the model. Radial basis function is used to construct an implicit surface which smoothly interpolates with the transition regions. Continuing the drag-and-drop operation will make the system recalculate the blending regions and reconstruct the transition regions. The drag-and-drop operation can be compound in a constructive solid geometry (CSG) manner to interactively construct a complex point-based model from multiple simple ones. Experimental results showed that our method generates good quality transition regions between two raw point clouds and can effectively reduce the rate of overlapping during the blending.展开更多
The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure ...The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure code algorithm, it is more efficiency because any figure searching is no longer necessary. The code-series (CS), which are organized from node association table, have the holo-information nature, so that both the content and the sign of each gain-term can be determined via the coded method. The principle of this method is obvious and it is suited for computer programming. The capability of the computer-aided analysis for the active network, such as operation amplifier network, can be enhanced.展开更多
The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful...The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful application of genetic programming. However, the need for sharing data among nodes in the syntactic tree becomes especially acute when evolving modular programs. It has been shown before that it may be beneficial that modules themselves be node-attached. The paper presents extensions to standard genetic programming (the so-called contexts and context blocks) that allow for straight-forward storage, retrieval, transfer, and modification of data stored in the context of a syntactic tree, and shared by multiple nodes. Framework is thus provided for both: data sharing and node-attached modules. Finally, using context blocks, a genetic algorithm has been embedded within genetic programming to evolve values of constants. In genetic programming evolution of constants has been a long-standing problem. The paper shows how context blocks can be utilized to provide a more granular and flexible approach to their evolution. As shown in previous works, node-attached modules perform favorably when compared with existing approaches. Concerning evolution of context block constants, it is shown here that they too perform favorably when compared with ephemeral constants.展开更多
In this study, we investigate the optimal location of access points (APs) to connect end nodes with a service provider through power-line communication in smartgrid communication networks. APs are the gateways of po...In this study, we investigate the optimal location of access points (APs) to connect end nodes with a service provider through power-line communication in smartgrid communication networks. APs are the gateways of power-distribution communication networks, connecting users to control centers. Hence, they are vital for the reliable, safe, and economical operation of a power system. This paper proposes a planning method for AP allocation that takes into consideration economics, reliability, network delay, and (n-l) resilience. First, an optimization model for the AP location is established, which minimizes the cost of installing APs, while satisfying the reliability, network delay, and (n-1) resilience constraints. Then, an improved genetic algorithm is proposed to solve the optimization problem. The simulation results indicate that the proposed planning method can deal with diverse network conditions satisfactorily. Furthermore, it can be applied effectively with high flexibility and scalability.展开更多
Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of ...Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of electric appliances.The basic motivation of our solution is to utilize the collaboration among a mass of low-cost sensor nodes and actuator nodes to make life convenient.To achieve it,we design a novel system architecture with assembled component modules.In particular,we address some key technical challenges:1) Field-Programmable Gate Array (FPGA) Implementation of Adaptive Differential Pulse Code Modulation (ADPCM) for audio data;2) FPGA Implementation of Lempel Ziv Storer Szymanski (LZSS) for bulk data;3) combination of complex control logic.Finally,a set of experiments are presented to evaluate the performance of our solution.展开更多
In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the ti...In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the time from initial design of WSN applications to their implementation as a major research topic. RF communication programs for WSN nodes are generally written on microcontroller units (MCUs) for universal asynchronous receiver/transmitter (UART) data communication, however nowadays radio frequency (RF) designs based on field-programmable gate array (FPGA) have emerged as a very powerful alternative, due to their parallel data processing ability and software reconfigurability. In this paper, the authors present a prototype of a flexible multi-node transceiver and monitoring system. The prototype is designed for time-critical applications and can be also reconfigured for other applications like event tracking. The processing power of FPGA is combined with a simple communication protocol. The system consists of three major parts: wireless nodes, the FPGA and display used for visualization of data processing. The transmission protocol is based on preamble and synchronous data transmission, where the receiver adjusts the receiving baud rate in the range from min. 300 to max. 2400 bps. The most important contribution of this work is using the virtual PicoBlaze Soft-Core Processor for controlling the data transmission through the RF modules. The proposed system has been evaluated based on logic utilization, in terms of the number of slice flip flops, the number of 4 input LUTs (Look-Up Tables) and the number of bonded lOBs (Input Output Blocks). The results for capacity usage are very promising as compared to other similar research.展开更多
基金The National Natural Science Foundation of China(No50475041)
文摘Based on the coded and non-coded targets, the targets are extracted from the images according to their size, shape and intensity etc., and thus an improved method to identify the unique identity(D) of every coded target is put forward and the non-coded and coded targets are classified. Moreover, the gray scale centroid algorithm is applied to obtain the subpixel location of both uncoded and coded targets. The initial matching of the uncoded target correspondences between an image pair is established according to similarity and compatibility, which are based on the ID correspondences of the coded targets. The outliers in the initial matching of the uncoded target are eliminated according to three rules to finally obtain the uncoded target correspondences. Practical examples show that the algorithm is rapid, robust and is of high precision and matching ratio.
文摘Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are mainly discussed.Based on this,the advantages of LabVIEW's interface development and Matlab's rich data operation functions are combined to achieve the fitting of explosion pressure field and dynamic compensation of temperature measured.
基金National Natural Science Foundation of China(No.61806006)Innovation Program for Graduate of Jiangsu Province(No.KYLX160-781)University Superior Discipline Construction Project of Jiangsu Province。
文摘The self-attention networks and Transformer have dominated machine translation and natural language processing fields,and shown great potential in image vision tasks such as image classification and object detection.Inspired by the great progress of Transformer,we propose a novel general and robust voxel feature encoder for 3D object detection based on the traditional Transformer.We first investigate the permutation invariance of sequence data of the self-attention and apply it to point cloud processing.Then we construct a voxel feature layer based on the self-attention to adaptively learn local and robust context of a voxel according to the spatial relationship and context information exchanging between all points within the voxel.Lastly,we construct a general voxel feature learning framework with the voxel feature layer as the core for 3D object detection.The voxel feature with Transformer(VFT)can be plugged into any other voxel-based 3D object detection framework easily,and serves as the backbone for voxel feature extractor.Experiments results on the KITTI dataset demonstrate that our method achieves the state-of-the-art performance on 3D object detection.
基金Supported by the National 863 High-tech Program of China (No.2003AA121560) and High-tech Project of Jiangsu Province (No.BG2003001).
文摘This paper investigates the maximal achievable multi-rate throughput problem of a multicast ses-sion at the presence of network coding. Deviating from previous works which focus on single-rate network coding, our work takes the heterogeneity of sinks into account and provides multiple data layers to address the problem. Firstly formulated is the maximal achievable throughput problem with the assumption that the data layers are independent and layer rates are static. It is proved that the problem in this case is, unfortunately, Non-deterministic Polynomial-time (NP)-hard. In addition, our formulation is extended to the problems with dependent layers and dynamic layers. Furthermore, the approximation algorithm which satisfies certain fair-ness is proposed.
基金Funded partly by Heilongjiang Province Financial Fund for Researchers Returning from Abroad
文摘We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring alnicos defined as index track and sub-division track, respectively. The index track is magnetized based on the improved gray code, with linear halls placed around the track evenly. The outputs of linear halls show the region the rotor belongs to. The sub-division track is magnetized to N-S-N-S (north-south-north-south), and the number of N-S pole pairs is determined by the index track. Three linear hall sensors with an air-gap of 2 mm are used to translate the magnetic filed to voltage signals. The relative offset in a single N-S is obtained through look-up. The magnetic encoder is calibrated using a higher-resolution incremental optical encoder. The pulse output from the optical encoder and hall signals from the magnetic encoder are sampled at the same time and transmitted to a computer, and the relation between them is calculated, and stored in the FLASH of MCU (micro controller unit) for look-up. In the working state, the absolute angle is derived by looking-up with hall signals. The structure is simple and the manufacturing cost is very low and suitable for mass production.
文摘The positions of braiding carrier in track and column braiding are represented by a diagrammatic braiding plan and a corresponding lattice-array is defined. A set is then formed so that the permutation analysis can be performed to represent the movement of carriers in a braiding process. The process of 4-step braiding is analyzed as an example to describe the application of the proposed method by expressing a braiding cycle as a product of disjoint cycles. As a result, a mapping relation between the disjoint cycles and the movement of carriers is deduced. Following the same analysis principles, a process of 8-step braiding and the corresponding initial state of the lattice-array is developed. A successful permutation analysis to the process manifests the general suitability of the proposed method.
基金Supported by a grant from Medical Innovation Fund Project of Fujian Provincial Health Bureau (No.2007-CXB-4)
文摘Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival rate.However,the sensitivity and specificity of the screening protocols which was widely used in clinic now are considered to be unsatisfactory.Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) is one of the proteins that have been suggested to be a classic oncogene with transformation properties.The current study set out to discuss the clinical significance of LMP-1 on the screening of NPC.Methods: Three hundred patients who visited our institution (Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou,China) with ENT symptoms between 2007 and 2008 were involved in this study,and all of them were agreed to be involved in this investigation.Not only did they undergo nasopharyngeal swab to obtain cells for the LMP-1 polymerase chain reaction (PCR) analysis,but also nasopharyngeal biopsy were taken to identify the diagnosis.Results: An amount of DNA that was sufficient for PCR was extracted from 243 (81%) swab samples,the positive rate of LMP-1 of those with non-nasopharyngeal carcinoma was 3.85% (4/108),which was much lower than those with nasopharyngeal carcinoma (P < 0.05).By detecting LMP-1 in nasopharyngeal swabs,NPC was diagnosed with a sensitivity of 88.15% (119 of 135 patients),specificity of 96.30% (104 of 108 patients),a positive predictive value of 95.2% (119 of 123 patients),a negative predictive value of 86.67% (104 of 120 patients),accuracy of 91.77%,and Youden index of 84.45%.Conclusion: The nasopharyngeal swab coupled with PCR-based EBV LMP-1 detection have high sensitivity and specificity,and also good repeatability,it could serve as part of the screening program for high-risk populations.
文摘Endometrial cancer (EC) is the most common and lethal gynaecological cancer type in Europe and in North America. Frequently EC arises more in the corpus proper and manifests as round, polypoid expansile masses, but it may also originate in the lower uterine segment or spread in endometrium with necrosis and hemorrhage. The analysis was performed using a custom panel containing all DNA sequences loci coding pre-miRNAs and genes related to biogenesis and regulation of sncRNAs in normal and tumor tissues extracted from 6 unrelated patients with endometrial carcinoma. The identified variations were correlated with mature miRNAs differentially expressed in the same normal and tumor endometrial tissues. The comparison analysis confirmed the high degree of cellular and genetic intratumoral heterogeneity with a temporal and spatial miRNA expression distribution in association with genomic variants identified. The classification of specific DNA mutations, onto the loci identified, should be suitable to characterize possible instability genome regions and help classification of tumors to ameliorate the clinical management of patients affected by endometrial carcinoma.
基金Supported by the National Natural Science Foundation of China (60903188), Shanghai Education Commission Innovation Foundation (11YZ192) and World Expo Science and Technology Special Fund of Shanghai Science and Technology Commission (08dz0580202).
文摘Integer overflow vulnerability will cause buffer overflow. The research on the relationship between them will help us to detect integer overflow vulnerability. We present a dynamic analysis methods RICB (Run-time Integer Checking via Buffer overflow). Our approach includes decompile execute file to assembly language; debug the execute file step into and step out; locate the overflow points and checking buffer overflow caused by integer overflow. We have implemented our approach in three buffer overflow types: format string overflow, stack overflow and heap overflow. Experiments results show that our approach is effective and efficient. We have detected more than 5 known integer overflow vulnerabilities via buffer overflow.
文摘To test the reliability and stability of the inspecting program of the electronic inspection system for raw silk,a simulating program is developed to simulate various defect cases with the software tool of Laboratory Virtual Instrument Engineering Workbench(LabVIEW).Many techniques,such as random numbers,shift registers,for loop,case structures and waveforms,are used to facilitate the simulation.The simulated defects are inspected by the inspecting program successfully,which proves the effectiveness of the simulating program.
文摘MicroRNAs (miRNAs), which are small noncoding RNA molecules, play important roles in the post-transcriptional regulation process. The microRNA-21 gene (miR-21) has been reported to be highly expressed in various solid tumors, including breast cancer. Bone morphogenetic protein-6 (BMP-6) has been identified as an inhibitor of breast cancer epithelial-mesenchymal transition (EMT) through rescuing E-cadherin expression. We initiated experi- ments to identify the relationships between miR-21 and BMP-6 in breast cancer progression. Real-time PCR analysis showed that miR-21 expression was very high in MDA-MB-231 cells that expressed little BMP-6. A reverse correla- tion between BMP-6 and miR-21 was also determined in breast cancer tissue samples. Moreover, BMP-6 inhibited miR-21 transcription in MDA-MB-231 cells. In order to investigate how BMP-6 inhibited the miR-21 promoter (miPPR-21), we constructed a series of miPPR-21 reporters. Luciferase assay results indicated that BMP-6 inhibited miPPR-21 activity through the E2-box and AP-l-binding sites. We also demonstrated that both δEF1 and TPA in- duced miR-21 expression. Using site-directed mutation and CHIP assay, we found that δEF1 induced miPPR-21 ac- tivity by binding to the E2-box on miPPR-21. Moreover, TPA triggered miPPR-21 activity through the AP-I binding sites. BMP-6 treatment significantly reduced the binding of these factors to miPPR-21 by decreasing the expression of δEF1 and c-Fos/c-Jun. We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activ- ity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion. δEF1 overexpression and TPA induction blocked this inhibitory effect of BMP-6. In conclusion, BMP-6-induced inhibition of miR-21 suggests that BMP-6 may function as an anti-metastasis factor by a mechanism involving transcriptional repression of miR-21 in breast cancer.
基金Project supported by the National Natural Science Foundation of China (Nos. 60473106 and 60333010)the Program for Chang-jiang Scholars and Innovative Research Team in University (No. IRT0652), China
文摘With the rapid development of 3D digital photography and 3D digital scanning devices, massive amount of point samples can be generated in acquisition of complex, real-world objects, and thus create an urgent need for advanced point-based processing and editing. In this paper, we present an interactive method for blending point-based geometries by dragging-and- dropping one point-based model onto another model’s surface metaphor. We first calculate a blending region based on the polygon of interest when the user drags-and-drops the model. Radial basis function is used to construct an implicit surface which smoothly interpolates with the transition regions. Continuing the drag-and-drop operation will make the system recalculate the blending regions and reconstruct the transition regions. The drag-and-drop operation can be compound in a constructive solid geometry (CSG) manner to interactively construct a complex point-based model from multiple simple ones. Experimental results showed that our method generates good quality transition regions between two raw point clouds and can effectively reduce the rate of overlapping during the blending.
文摘The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure code algorithm, it is more efficiency because any figure searching is no longer necessary. The code-series (CS), which are organized from node association table, have the holo-information nature, so that both the content and the sign of each gain-term can be determined via the coded method. The principle of this method is obvious and it is suited for computer programming. The capability of the computer-aided analysis for the active network, such as operation amplifier network, can be enhanced.
文摘The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful application of genetic programming. However, the need for sharing data among nodes in the syntactic tree becomes especially acute when evolving modular programs. It has been shown before that it may be beneficial that modules themselves be node-attached. The paper presents extensions to standard genetic programming (the so-called contexts and context blocks) that allow for straight-forward storage, retrieval, transfer, and modification of data stored in the context of a syntactic tree, and shared by multiple nodes. Framework is thus provided for both: data sharing and node-attached modules. Finally, using context blocks, a genetic algorithm has been embedded within genetic programming to evolve values of constants. In genetic programming evolution of constants has been a long-standing problem. The paper shows how context blocks can be utilized to provide a more granular and flexible approach to their evolution. As shown in previous works, node-attached modules perform favorably when compared with existing approaches. Concerning evolution of context block constants, it is shown here that they too perform favorably when compared with ephemeral constants.
基金supported by the National High Technology Research and Development Program of China(2012AA050801)
文摘In this study, we investigate the optimal location of access points (APs) to connect end nodes with a service provider through power-line communication in smartgrid communication networks. APs are the gateways of power-distribution communication networks, connecting users to control centers. Hence, they are vital for the reliable, safe, and economical operation of a power system. This paper proposes a planning method for AP allocation that takes into consideration economics, reliability, network delay, and (n-l) resilience. First, an optimization model for the AP location is established, which minimizes the cost of installing APs, while satisfying the reliability, network delay, and (n-1) resilience constraints. Then, an improved genetic algorithm is proposed to solve the optimization problem. The simulation results indicate that the proposed planning method can deal with diverse network conditions satisfactorily. Furthermore, it can be applied effectively with high flexibility and scalability.
基金supported by the Natural Science Foundation of China under Grant No.61070206,No.61070205and No.60833009the National973Project of China under Grant No.2011CB302701+2 种基金the program of New Century Excellent Talents in University of China under Grant No.NCET-080737the Beijing National Natural Science Foundation under Grant No.4092030the Cosponsored Project of Beijing Committee of Education
文摘Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of electric appliances.The basic motivation of our solution is to utilize the collaboration among a mass of low-cost sensor nodes and actuator nodes to make life convenient.To achieve it,we design a novel system architecture with assembled component modules.In particular,we address some key technical challenges:1) Field-Programmable Gate Array (FPGA) Implementation of Adaptive Differential Pulse Code Modulation (ADPCM) for audio data;2) FPGA Implementation of Lempel Ziv Storer Szymanski (LZSS) for bulk data;3) combination of complex control logic.Finally,a set of experiments are presented to evaluate the performance of our solution.
文摘In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the time from initial design of WSN applications to their implementation as a major research topic. RF communication programs for WSN nodes are generally written on microcontroller units (MCUs) for universal asynchronous receiver/transmitter (UART) data communication, however nowadays radio frequency (RF) designs based on field-programmable gate array (FPGA) have emerged as a very powerful alternative, due to their parallel data processing ability and software reconfigurability. In this paper, the authors present a prototype of a flexible multi-node transceiver and monitoring system. The prototype is designed for time-critical applications and can be also reconfigured for other applications like event tracking. The processing power of FPGA is combined with a simple communication protocol. The system consists of three major parts: wireless nodes, the FPGA and display used for visualization of data processing. The transmission protocol is based on preamble and synchronous data transmission, where the receiver adjusts the receiving baud rate in the range from min. 300 to max. 2400 bps. The most important contribution of this work is using the virtual PicoBlaze Soft-Core Processor for controlling the data transmission through the RF modules. The proposed system has been evaluated based on logic utilization, in terms of the number of slice flip flops, the number of 4 input LUTs (Look-Up Tables) and the number of bonded lOBs (Input Output Blocks). The results for capacity usage are very promising as compared to other similar research.