热敏灸艾条的薄层色谱鉴别及绿原酸含量的测定

目的:对热敏灸艾条的质量标准进行研究。方法:采用薄层色谱法鉴别对处方中川芎、独活等中药材进行鉴定;采用药典高效液相法对热敏灸艾条中绿原酸含量进行测定。结果:热敏灸艾条生产质量状况良好。结论:本实验为热敏灸艾条的质量标准的完善提供了科学的依据。

Clinical observation on heat-sensitive moxibustion plus lactulose for postoperative constipation of mixed hemorrhoid due to spleen deficiency

Objective:To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods:A total of 70 patients were randomized into a treatment group and a control group,with 35 cases in each group by a random number table.Patients in the control group received lactulose oral liquid alone,while those in the treatment group received additional heat-sensitive moxibustion at Shenque(CV 8).The treatment was given once a day for 15 consecutive days.The defecation interval time,defecation duration,the scores of stool form,visual analog scale(VAS)and patient assessment of constipation quality of life questionnaire(PAC-QOL),as well as the serum substance P(SP)and nitric oxide(NO)levels were measured before and after treatment.Results:After treatment,the stool form score,defecation interval time and defecation duration in the two groups dropped significantly(all P<0.05),and they were lower in the treatment group than in the control group(all P<0.05).After treatment,the VAS scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the PAC-QOL scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the serum SP and NO levels in the two groups improved significantly(all P<0.05),and showed statistically significant differences between the treatment group and the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus lactulose oral liquid can improve stool form,shorten defecation interval time and defecation duration,alleviate defecation pain,and improve quality of life(QOL)for patients with postoperative constipation of mixed hemorrhoid,which may be related to the regulation of the SP and NO levels.

Effect of heat-sensitive moxibustion on facial function score in patients with facial paralysis

Objective： To observe and compare the therapeutic efficacies of heat-sensitive moxibustion plus Western medication, dry Western medication, and acupuncture plus TDP in treating peripheral facial palsy （FP）. Methods： Ninety FP patients were randomized into a Western medication group, a heat-sensitive moxibustion group, and an acupuncture group by using sealed envelope, 30 cases in each group. The Western medication group was intervened by conventional Western medication; the heat-sensitive moxibustion group was by heat-sensitive moxibustion in addition to the same Western medication; the acupuncture group was by the Western medication plus acupuncture and TDP radiation. For the three groups, 6-day treatment was taken as a treatment course, with a 2-day interval between 2 courses, and totally 4 treatment courses were observed. Results： After intervention, the modified Portmann scores were changed significantly in the three groups （P〈0.05）, and the improvements in the heat-sensitive moxibustion group and the acupuncture group were both superior to that in the Western medication group. The recovery plus markedly effective rate of the acupuncture group was significantly different from that of the Western medication group （P〈0.05）, and there was a significant difference in comparing the recovery plus markedly effective rate between the heat-sensitive moxibustion group and acupuncture group （P〈0.05）. Conclusion： Heat-sensitive moxibustion is effective in treatment peripheral facial paralysis, and this method is free of pain, causing no adverse reactions, and worth promotion in clinic.

Effect of heat-sensitive moxibustion plus psychological intervention on SP, 5-HT and quality of life in patients with irritable bowel syndrome

Objective： To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P（SP） and 5-hydroxytryptamine（5-HT）, as well as the quality of life（QOL） in patients with irritable bowel syndrome（IBS）. Methods： A total of 120 IBS patients were divided into three groups by random sampling method, 40 cases in each group. The heat-sensitive moxibustion group received heat-sensitive moxibustion, the psychological intervention group received psychological intervention, while the observation group received both methods. The therapeutic efficacy was evaluated after 3 courses of treatment. Results： After treatment, the therapeutic efficacy of the observation group was better than that of the heat-sensitive moxibustion group and the psychological intervention group（P〈0.01）, and the heat-sensitive moxibsution group was better than the psychological intervention group（P〈0.05）. In comparing the bowel symptom scale（BSS）, the observation group was better than the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）. In the comparison of QOL, the observation group was significantly superior to the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. In comparing serum SP and 5-HT, the observation group was markedly better than the other two groups（P〈0.05）, and there were significant differences between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. The self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were used to estimate the mental state of the three groups, revealing that the observation group was better than the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）, and there were significant differences between the latter two groups（P〈0.05）. Conclusion： Heat-sensitive moxibustion plus psychological intervention can regulate the levels of SP and 5-HT, improve BSS, SDS, SAS and QOL in treating IBS.

Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels

Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.

Effect of moxibustion at sensitized-acupoints on quality of life in patients with chronic superficial gastritis

Objective:To compare the efficacy difference between moxibustion at sensitized-acupoints and non-sensitized-acupoints using the same group of acupoints.Methods:A total of 139 patients with chronic superficial gastritis were divided into a sensitized acupoint group(102 cases)and a non-sensitized acupoint group(37 cases)based on whether acupoint sensitization occurred.The SPSS version 19.0 statistical software propensity score matching function was used to balance the baseline data between the groups.Finally,29 pairs of matched patients were included,namely 29 cases in the sensitized acupoint group and 29 cases in the non-sensitized acupoint group.Both groups were treated with moxibustion therapy.The treatment lasted for 30 min per time,and was performed every other day for 8 weeks.Changes in the traditional Chinese medicine(TCM)symptom score and the short-form 36-item health survey(SF-36)score in both groups were observed before and after treatment,as well as the clinical efficacy.Results:The covariates of age,course of disease,TCM symptom score and SF-36 score in the two groups were balanced after matching(all P>0.05).After treatment,the total effective rate was 100.0%in the sensitized acupoint group and 79.3%in the non-sensitized acupoint group.The difference in the total effective rate between the two groups was statistically significant(P<0.01).After treatment and at the 4-week follow-up,the TCM symptom scores in the sensitized acupoint group were significantly lower than those in the non-sensitized acupoint group(all P<0.01);the SF-36 scores in the sensitized acupoint group were significantly higher than those in the non-sensitized acupoint group(all P<0.01).Conclusion:With the same group of acupoints,the sensitized acupoints have a better therapeutic effect and long-term efficacy than the non-sensitized acupoints in the treatment of chronic superficial gastritis.

Clinical observation of tuina plus heat-sensitive moxibustion for temporomandibular disorders

Objective： To observe the clinical efficacy of tuina plus heat-sensitive moxibustion in treating temporomandibular disorders （TMD）. Methods： Fifty patients with TMD were randomized into a treatment group and a control group, 25 cases in each group. The treatment group was intervened by tuina plus heat-sensitive moxibustion, while the control group was by medication. The Fricton-Shiffman craniomandibular index （CMI） was observed before and after intervention, and the clinical efficacies of the two groups were also evaluated. Results： There was no significant difference in comparing the CMI score between the two groups before intervention （P^0.05）. After a treatment course, there were significant improvements in evaluating the CMI score in both groups （P^0.01）, and the improvement was more significant in the treatment group than that in the control group （P〈0.01）. The total effective rate of the treatment group was significantly higher than that of the control group （P〈0.01）. Conclusion： Tuina plus heat-sensitive moxibustion is effective in treating TMD, and it＇s safe, without adverse reactions, thus worth promoting in clinic.

Clinical observation of heat-sensitive moxibustion for acute ischemic stroke

Objective To observe the clinical efficacy of heat-sensitive moxibustion in intervening acute ischemic stroke.Methods A total of 112 patients were divided into a control group and an observation group by the random number table method,with 56 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control group.The National Institute of Health stroke scale(NIHSS)and modified Barthel index(MBI)were evaluated,and the intracranial hemodynamic indicators including mean velocity(Vm),pulsatility index(PI)and resistance index(RI)were recorded,and the serum levels of superoxide dismutase(SOD)and homocysteine(HCY)were measured before and after treatment.Clinical efficacy was evaluated after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the NIHSS scores in both groups decreased significantly(both P<0.05),and the MBI scores increased significantly(both P<0.05).The improvements of NIHSS and MBI scores in the observation group were superior to those in the control group(both P<0.05).Vm in both groups increased significantly(both P<0.05),PI and RI decreased(all P<0.05),and Vm,PI and RI in the observation group were superior to those in the control group(all P<0.05).The serum levels of SOD and HCY in the observation group were significantly improved,and were statistically different from those in the control group(both P<0.05).Conclusion Conventional treatment plus heat-sensitive moxibustion is effective in intervening acute ischemic stroke.It can promote the recovery of neurological function,improve daily activities,and improve intracranial blood flow,which may be related to the regulation of serum SOD and HCY levels.

Observation on therapeutic efficacy of heat-sensitive moxibustion plus Western medicine for diabetic peripheral neuropathy

Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus Western medicine in treating patients with diabetic peripheral neuropathy(DPN).Methods:A total of 70 patients with DPN were divided into an observation group and a control group by sealed envelope method combined with the random number table method,with 35 cases in each group.The control group was treated with routine medicine,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control group.After 2 courses of treatment,the scores of Toronto clinical scoring system(TCSS)and vibration perception threshold(VPT)in both groups were observed,and the clinical efficacy was compared.Results:During treatment,3 cases dropped out in the control group and 4 cases in the observation group.After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The scores of TCSS and VPT in both groups decreased after treatment,and the intra-group comparison showed statistical significance(both P<0.05).The scores of TCSS and VPT in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion:Heat-sensitive moxibustion plus Western medicine can improve the symptoms in patients with DPN,and has a better curative effect than the Western medicine alone.

Therapeutic efficacy and mechanism of heat-sensitive moxibustion for vascular dementia

Objective:To observe the clinical efficacy of heat-sensitive moxibustion for vascular dementia and explore its mechanism.Methods:A total of 70 patients with vascular dementia were randomized into an observation group and a control group,with 35 cases in each group.The control group was treated with piracetam,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment of the control group.The treatment lasted for 8 weeks.Before and after the treatment,the mini-mental state examination(MMSE),activity of daily living(ADL)and traditional Chinese medicine(TCM)symptom scores were assessed,and the levels of acetyl choline(Ach)and homocysteine(Hcy)were measured.The efficacy was evaluated after treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the MMSE and ADL scores in the observation group decreased significantly,and were lower than those in the control group(all P<0.05);the TCM symptom score of the observation group decreased significantly(P<0.05),while that of the control group had no significant change(P>0.05);the plasma Ach level in the observation group increased significantly(P<0.05),and the Hcy level decreased significantly(P<0.05),which were statistically different from those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus piracetam is effective in treating vascular dementia.It can significantly improve dementia symptoms and ADL,which may be related to the correction of plasma Ach and Hcy levels.

Therapeutic efficacy and mechanism of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease

Objective:To observe the clinical efficacy of heat-sensitive moxibustion for adjuvant treatment of depression in Parkinson disease and explore its mechanism.Methods:A total of 80 patients with Parkinson disease coupled with depression were randomized into an observation group and a control group,with 40 cases in each group.The control group was treated with levodopa and benserazide hydrochloride tablets and paroxetine tablets,while the observation group was treated with heat-sensitive moxibustion on the basis of the medications in the control group.The treatment course was 2 months.The Hamilton depression scale-17(HAMD-17),unified Parkinson's disease rating scale(UPDRS)and Parkinson's disease quality of life questionnaire-39(PDQ-39)were scored before and after the treatment,and the efficacy was evaluated after treatment.Levels of patients'serum dopamine(DA),5-hydroxytryptamine(5-HT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were detected before and after the treatment.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).The HAMD-17 scores in the two groups decreased significantly after treatment(both P<0.05),and the score in the observation group was obviously lower than that in the control group(P<0.05).The component scores and total scores of UPDRS in both groups decreased significantly(all P<0.05),and the scores in the observation group were lower than those in the control group(all P<0.05).The score of PDQ-39 in the observation group decreased significantly(P<0.05),and was lower than that in the control group(P<0.05).After treatment,the serum DA and 5-HT levels in the observation group increased significantly(both P<0.05)and the TNF-αand IL-6 levels decreased significantly(both P<0.05),which were statistically different from those in the control group(all P<0.05).Conclusion:Heat-sensitive moxibustion has certain auxiliary effect in treating depression in Parkinson disease,significantly improving clinical symptoms and the quality of life,which may be related to the up-regulation of DA and 5-HT levels and down-regulation of TNF-αand IL-6 levels.