期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
元胡止痛方对小鼠疼痛模型的镇痛作用及其“量-效”关系探索研究 被引量:10
1
作者 李俊芳 王鹏 +5 位作者 翟兴 肖学凤 张毅 李德凤 许海玉 杨洪军 《现代中药研究与实践》 CAS 2017年第3期21-24,共4页
目的研究元胡止痛方对小鼠疼痛模型的镇痛作用及其"量-效"关系探索。方法将健康ICR小鼠随机分为5个组,采用热板模型记录反应潜伏期和醋酸扭体模型观察扭体潜伏期及注射醋酸后20min内的扭体次数。用归一化法探索其"量效&q... 目的研究元胡止痛方对小鼠疼痛模型的镇痛作用及其"量-效"关系探索。方法将健康ICR小鼠随机分为5个组,采用热板模型记录反应潜伏期和醋酸扭体模型观察扭体潜伏期及注射醋酸后20min内的扭体次数。用归一化法探索其"量效"关系。结果在热板试验中,与模型组比较,给药60 min后,阳性药组与元胡止痛方16 g/kg和32 g/kg生药组痛阈时间明显延长(P<0.05)。在醋酸扭体试验中,与模型组比较,阳性药及各元胡止痛方组扭体次数明显减少(P<0.05)。归一化结果说明,在4~32 g/kg剂量范围内,元胡止痛方的剂量与其提高的痛阈值成正相关。结论元胡止痛方对小鼠疼痛模型有明显的镇痛作用,且呈现出剂量依赖性关系。 展开更多
关键词 元胡止痛方 镇痛作用 醋酸扭体模型 热板模型 量效关系
下载PDF
Hemorphin-4在中枢上水平对小鼠热板法痛阈和排便的调节
2
作者 张兆伟 秦妮娜 +1 位作者 陈锴 邹雨霞 《中国实验诊断学》 2018年第9期1623-1625,共3页
目的探究阿片样肽hemorphin-4(Tyr-Pro-Trp-Thr)在中枢上水平对热板致痛小鼠的痛阈调节及其对小鼠排便的影响。方法 (1)选择昆明系雌性小鼠,通过侧脑室埋管实现中枢给药;(2)热板模型,是测定中枢水平急性痛的经典方法,以"舔后足&qu... 目的探究阿片样肽hemorphin-4(Tyr-Pro-Trp-Thr)在中枢上水平对热板致痛小鼠的痛阈调节及其对小鼠排便的影响。方法 (1)选择昆明系雌性小鼠,通过侧脑室埋管实现中枢给药;(2)热板模型,是测定中枢水平急性痛的经典方法,以"舔后足"为痛反应指标;(3)以粪便颗粒数和总干重来评价药物对排便的调节。结果 (1)侧脑室注射hemorphin-4能够剂量依赖性地延迟小鼠舔后足的潜伏期;(2)阿片受体的非选择性拮抗剂naloxone几乎完全阻断hemorphin-4的镇痛作用;(3)hemorphin-4抑制排便所需的剂量远高于它在热板模型中的有效剂量。结论 (1)相较于甩尾模型,hemorphin-4在热板模型中表现出更高的镇痛活性;(2)拮抗剂阻断结果显示,hemorphin-4的镇痛可能是通过激活阿片受体介导;(3)hemorphin-4调节热板法痛阈的活性远高于它调节排便的活性,即hemorphin-4在发挥镇痛时不会导致排便障碍。 展开更多
关键词 hemorphin-4 热板模型 排便实验
下载PDF
Mathe matical model and calculation for heat transfer during condensation on surfaces of corrugated plates
3
作者 陈亚平 周强泰 施明恒 《Journal of Southeast University(English Edition)》 EI CAS 2003年第4期347-351,共5页
A mathematical model was established for condensation on surfaces of verticalcorrugated plates based on the mechanism of heat transfer enhancement to thin down the liquid filmdue to surface tension effect between corr... A mathematical model was established for condensation on surfaces of verticalcorrugated plates based on the mechanism of heat transfer enhancement to thin down the liquid filmdue to surface tension effect between corrugated plate surfaces and liquid films. The relative heattransfer coefficients of condensation on corrugation plates were calculated in contrast withequivalent vertical plane ones. The heat transfer enhancement effects for the main geometricparameters such as pitch, height, corrugation angle, tilt angle, and fillet radii of corrugationswere analyzed to guide the optimization of corrugation structure for application. A two-scalecorrugation is suggested, which can compromise both the enhanced heat transfer effect and adequatecross section area for flows, and it makes the heat transfer coefficient 1 to 2 times more than thatof an equivalent plane one. 展开更多
关键词 CONDENSATION enhancement of heat transfer corrugated plates plate-shellheat exchanger
下载PDF
Analysis of strain variation in cross shear zone of plate during snake hot rolling 被引量:1
4
作者 张涛 吴运新 +2 位作者 龚海 石文泽 蒋方敏 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第2期296-302,共7页
In order to study the distribution of equivalent and shear strain of aluminum alloy plate during snake hot rolling, several coupled thermo-mechanical finite element models(FEM) are established. Effects of speed ratio ... In order to study the distribution of equivalent and shear strain of aluminum alloy plate during snake hot rolling, several coupled thermo-mechanical finite element models(FEM) are established. Effects of speed ratio and offset distance on strain distribution of the plate are analyzed. The length of cross shear zone is defined to have a better understanding of the deformation characteristic in cross shear zone, which is the essential difference from symmetrical rolling in deformation zone. The results show that the equivalent strain and shear strain of lower part both increase with the increase of speed ratio, while the upper part decreases; the equivalent strain through the whole thickness decreases with ascending offset distance, while the shear strain of lower part increases. The length of cross shear zone quickly increases with ascending speed ratio and slightly decreases with ascending offset distance. The "positive" and "negative" cross shear zones are formed with the increase of speed ratio and offset distance, respectively. The value of the sensitivity coefficient of speed ratio is an order of magnitude bigger than the offset distance. However, the shear strain at center point increases with the ascending speed ratio and offset distance for different mechanism. As speed ratio increases, the asymmetry of the distribution of equivalent is becoming larger and the shear strain is generated in the same direction in cross shear zone. The FEM results agree well with experimental results. 展开更多
关键词 aluminum alloy plate snake hot rolling speed ratio offset distance cross shear zone
下载PDF
Temperature Distributions in Single Cell of Polymer Electrolyte Fuel Cell Simulated by an 1D Multi-plate Heat-Transfer Model and a 3D Numerical Simulation Model
5
作者 Akira Nishimura Masashi Baba +3 位作者 Kotaro Osada Takenori Fukuoka MasafumiHirota Eric Hu 《Journal of Energy and Power Engineering》 2015年第8期687-704,共18页
The purpose of this study is to verify an 1D multi-plate heat-transfer model estimating the temperature distribution on the interface between polymer electrolyte membrane and catalyst layer at cathode in single cell o... The purpose of this study is to verify an 1D multi-plate heat-transfer model estimating the temperature distribution on the interface between polymer electrolyte membrane and catalyst layer at cathode in single cell of polymer electrolyte fuel cell, which is named as reaction surface in this study, with a 3D numerical simulation model solving many governing equations on the coupling phenomena in the cell. The results from both models/simulations agreed well. The effects of initial operation temperature, flow rate, and relative humidity of supply gas on temperature distribution on the reaction surface were also investigated. It was found in both 1D and 3D simulations that, the temperature rise (i.e., Treact-Tini) of the reaction surface from initial operation temperature at 70℃ was higher than that at 80℃ irrespective of flow rate of supply gas. The effect of relative humidity of supply gas on Treact- Tini near the inlet of the cell was small. Compared to the previous studies conducted under the similar operation conditions, the Treact - Tini calculated by 1D multi-plate heat-transfer model in this study as well as numerical simulation using 3D model was reasonable. 展开更多
关键词 Polymer electrolyte fuel cell 1D multi-plate heat-transfer model 3D numerical simulation model temperaturedistribution.
下载PDF
Numerical Prediction of Film Cooling Effectiveness over Flat Plate using Variable Turbulent Prandtl Number Closures 被引量:1
6
作者 Tomasz Ochrymiuk 《Journal of Thermal Science》 SCIE EI CAS CSCD 2016年第3期280-286,共7页
Numerical simulations were performed to predict the film cooling effectiveness on the fiat plate with a three- dimensienal discrete-hole film cooling arrangement. The effects of basic geometrical characteristics of th... Numerical simulations were performed to predict the film cooling effectiveness on the fiat plate with a three- dimensienal discrete-hole film cooling arrangement. The effects of basic geometrical characteristics of the holes, i.e diameter D, length L and pitch S/D were studied. Different turbulent heat transfer models based on constant and variable turbulent Prandtl number approaches were considered. The variability of the turbulent Prandtl number Prt in the energy equation was assumed using an algebraic relation proposed by Kays and Crawford, or employing the Abe, Kondoh and Nagano eddy heat diffusivity closure with two differential transport equations for the temperature variance ko and its destruction rate εθ The obtained numerical results were directly compared with the data that came from an experiment based on Transient Liquid Crystal methodology. All implemented models for turbulent heat transfer performed sufficiently well for the considered case. It was confirmed, however, that the two- equation closure can give a detailed look into film cooling problems without using any time-consuming and inherently unsteady models. 展开更多
关键词 turbulent heat flux two-equation model turbulent Prandtl number film cooling
原文传递
Heat Transfer Optimization for Air-Mist Cooling between a Stack of Parallel Plates 被引量:3
7
作者 Roy J.Issa 《Journal of Thermal Science》 SCIE EI CAS CSCD 2010年第3期253-260,共8页
A theoretical model is developed to predict the upper limit heat transfer between a stack of parallel plates subject to multiphase cooling by air-mist flow.The model predicts the optimal separation distance between th... A theoretical model is developed to predict the upper limit heat transfer between a stack of parallel plates subject to multiphase cooling by air-mist flow.The model predicts the optimal separation distance between the plates based on the development of the boundary layers for small and large separation distances,and for dilute mist conditions.Simulation results show the optimal separation distance to be strongly dependent on the liquid-to-air mass flow rate loading ratio,and reach a limit for a critical loading.For these dilute spray conditions,complete evaporation of the droplets takes place.Simulation results also show the optimal separation distance decreases with the increase in the mist flow rate.The proposed theoretical model shall lead to a better understanding of the design of fins spacing in heat exchangers where multiphase spray cooling is used. 展开更多
关键词 Air-mist MULTIPHASE Heat transfer Liquid-to-air loading
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部