AIM： To investigate the hypothesis that the protective effects of curcumin in hepatic warm ischemia/reperfusion （I/R） injury are associated with increasing heat shock protein 70 （Hsp70） expression and antioxidant...AIM： To investigate the hypothesis that the protective effects of curcumin in hepatic warm ischemia/reperfusion （I/R） injury are associated with increasing heat shock protein 70 （Hsp70） expression and antioxidant enzyme activity. METHODS： Sixty Sprague-Dawley male rats were randomly divided into sham, I/R, C ＋ I/R groups. The model of reduced-size liver warm ischemia and reperfusion was used. Curcumin （50 mg/kg） was administered by injection through a branch of superior mesenteric vein at 30 min before ischemia in C ＋ I/R group. Five rats were used to investigate the survival during 1 wk after operation in each group. Blood samples and liver tissues were obtained in the remaining animals after 3, 12, and 24 h of reperfusion to assess serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, liver tissue NO2- ＋ NO3-, malondialdehyde （MDA） content, superoxide dismutase （SOD）, catalase （CAT）, nitricoxide synthase （NOS） and myeloperoxidase （MPO） activity, HspT0 expression and apoptosis ratio. RESULTS： Compared with I/R group, curcumin pretreatment group showed less ischemia/reperfusioninduced injury. CAT and SOD activity and Hsp70 expression increased significantly. A higher rate of apoptosis was observed in I/R group than in C ＋ I/R group, and a significant increase of MDA, NO2^- ＋ NO3^- and MPO level in liver tissues and serum transaminase concentration was also observed in I/R group compared to C ＋ I/R group. Curcumin also decreased the activity of inducible NO synthase （iNOS） in liver after reperfusion,but had no effect on the level of endothelial NO synthase （eNOS） after reperfusion in liver. The 7 d survival rate was significantly higher in C ＋ I/R group than in I/R group. CONCLUSION： Curcumin has protective effects against hepatic I/R injury. Its mechanism might be related to the overexpression of Hsp70 and antioxidant enzymes.展开更多
This paper is to report a prediction model for thermal protective performance of multilayer fabrics based on Matlab neural network toolbox. Then a back propagation (BP) neural network model is developed to predict the...This paper is to report a prediction model for thermal protective performance of multilayer fabrics based on Matlab neural network toolbox. Then a back propagation (BP) neural network model is developed to predict thermal protective performance of multilayer fabrics for firefighters. The network consists of twelve input nodes, six hidden nodes, and one output node. The inputs are weight, thickness, density of warp and weft, limited oxygen index (LOI), and heat conductivity of each-layer fabric. Thermal protective performance (TPP) rating of multilayer fabrics is the output. In this paper, the data from the experiments are used as learning information for the neural network to develop a reliable prediction model. Finnally the model performance is verified, and the proposed model can be applied to predict the thermal protective performance of multilayer fabrics for firefighters.展开更多
An experimental measurement and calculation method which consist of thermal response model, convergence criteria and control algorithms, is proposed in this paper for the determination of heat flux in a scramjet combu...An experimental measurement and calculation method which consist of thermal response model, convergence criteria and control algorithms, is proposed in this paper for the determination of heat flux in a scramjet combus- tot. Numerical simulations are done to evaluate the effectiveness of the proposed method, and experiments are made in the direct-connect hydrocarbon fueled scramjet combustor of Mach-6 flight for different equivalence ra- tios. The distribution of heat flux along the axial and circumferential directions can be obtained using the pro- posed method. The distribution of heat flux is uneven which is caused by the aerodynamic heating, combustion heat release and changes of section area, and the peak heat flux can be more than 2MW/m^2 during the experi- ments. Heat flux increases with the increase in equivalence ratio for the same Mach number. And axial distribu- tion of heat flux is uniform for different equivalence ratios. In addition, the combustion heat release area of the combustion chamber can therefore be concluded which is useful for guiding the structural design of the thermal protection system.展开更多
文摘AIM： To investigate the hypothesis that the protective effects of curcumin in hepatic warm ischemia/reperfusion （I/R） injury are associated with increasing heat shock protein 70 （Hsp70） expression and antioxidant enzyme activity. METHODS： Sixty Sprague-Dawley male rats were randomly divided into sham, I/R, C ＋ I/R groups. The model of reduced-size liver warm ischemia and reperfusion was used. Curcumin （50 mg/kg） was administered by injection through a branch of superior mesenteric vein at 30 min before ischemia in C ＋ I/R group. Five rats were used to investigate the survival during 1 wk after operation in each group. Blood samples and liver tissues were obtained in the remaining animals after 3, 12, and 24 h of reperfusion to assess serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, liver tissue NO2- ＋ NO3-, malondialdehyde （MDA） content, superoxide dismutase （SOD）, catalase （CAT）, nitricoxide synthase （NOS） and myeloperoxidase （MPO） activity, HspT0 expression and apoptosis ratio. RESULTS： Compared with I/R group, curcumin pretreatment group showed less ischemia/reperfusioninduced injury. CAT and SOD activity and Hsp70 expression increased significantly. A higher rate of apoptosis was observed in I/R group than in C ＋ I/R group, and a significant increase of MDA, NO2^- ＋ NO3^- and MPO level in liver tissues and serum transaminase concentration was also observed in I/R group compared to C ＋ I/R group. Curcumin also decreased the activity of inducible NO synthase （iNOS） in liver after reperfusion,but had no effect on the level of endothelial NO synthase （eNOS） after reperfusion in liver. The 7 d survival rate was significantly higher in C ＋ I/R group than in I/R group. CONCLUSION： Curcumin has protective effects against hepatic I/R injury. Its mechanism might be related to the overexpression of Hsp70 and antioxidant enzymes.
文摘This paper is to report a prediction model for thermal protective performance of multilayer fabrics based on Matlab neural network toolbox. Then a back propagation (BP) neural network model is developed to predict thermal protective performance of multilayer fabrics for firefighters. The network consists of twelve input nodes, six hidden nodes, and one output node. The inputs are weight, thickness, density of warp and weft, limited oxygen index (LOI), and heat conductivity of each-layer fabric. Thermal protective performance (TPP) rating of multilayer fabrics is the output. In this paper, the data from the experiments are used as learning information for the neural network to develop a reliable prediction model. Finnally the model performance is verified, and the proposed model can be applied to predict the thermal protective performance of multilayer fabrics for firefighters.
文摘An experimental measurement and calculation method which consist of thermal response model, convergence criteria and control algorithms, is proposed in this paper for the determination of heat flux in a scramjet combus- tot. Numerical simulations are done to evaluate the effectiveness of the proposed method, and experiments are made in the direct-connect hydrocarbon fueled scramjet combustor of Mach-6 flight for different equivalence ra- tios. The distribution of heat flux along the axial and circumferential directions can be obtained using the pro- posed method. The distribution of heat flux is uneven which is caused by the aerodynamic heating, combustion heat release and changes of section area, and the peak heat flux can be more than 2MW/m^2 during the experi- ments. Heat flux increases with the increase in equivalence ratio for the same Mach number. And axial distribu- tion of heat flux is uniform for different equivalence ratios. In addition, the combustion heat release area of the combustion chamber can therefore be concluded which is useful for guiding the structural design of the thermal protection system.
