敏感穴位热灸法对兔股骨头缺血性坏死修复的病理观察

目的研究敏感穴位热灸法对兔股骨头缺血性坏死修复的影响,探讨热敏灸治疗股骨头缺血性坏死的疗效及作用机制。方法 48只大白兔模型随机平均分成传统艾灸对照组、热敏灸治疗组及空白对照组。治疗后进行常规组织病理学股骨头切片观察。结果对比三组治疗组光镜组织学观察分级,空白对照组呈进行性坏死型;传统艾灸组与空白对照组差异无显著性意义(P>0.05);热敏灸组与传统艾灸组差异有显著性意义(P<0.O5)。结论通过病理学观察,热敏灸对兔股骨头缺血性坏死修复有较好的影响,对临床治疗股骨头坏死有积极的参考意义。

敏感穴位热灸法对兔股骨头缺血性坏死血管内皮生长因子表达的影响

目的研究敏感穴位热灸法对兔股骨头缺血性坏死血管内皮生长因子（VEGF）表达的影响，探讨VEGF表达水平与股骨头缺血性坏死的关系及作用机制。方法从造模成功并寻找出热敏点的模型中随机取48只，根据治疗方式不同随机分成3组，即传统艾灸对照组、热敏灸治疗组及空白对照组，每组16只动物。前两种方法每日治疗1次，连续治疗2周休息3～5天再继续治疗，3个月为一疗程。空白对照组不进行治疗，只进行一般情况观察。于第1，2，3，4疗程阶段各处死4只兔子，取双侧股骨头标本进行血管内皮生长因子免疫组化检测。结果热敏灸与其它两组比较具有较好的VEGF表达效果。结论热敏灸对股骨头缺血性坏死的VEGF表达具有正向调节的作用，达到促进血管生成和增加血管的通透性的效果。

敏感穴位热灸法对兔股骨头缺血性坏死血液流变学的影响

目的研究敏感穴位热灸法对兔股骨头缺血性坏死血液流变学的影响，探讨血液流变与股骨头缺血性坏死的关系及敏感穴位热灸法作用机制。方法48只兔股骨头缺血性坏死模型随机分为传统艾灸对照组、热敏灸治疗组、空白对照组各16只。每日治疗1次，连续治疗2周，休息3—5日，3个月为1个疗程。治疗前后测定全血黏度、血浆黏度、红细胞聚集指数、凝血酶原时间、部分活化凝血酶原时间等指标。结果热敏灸治疗组全血黏度、血浆黏度、红细胞聚集指数、凝血酶原时间及部分活化凝血酶原时间，治疗前后差异有统计学意义（P〈0．01）；以上指标治疗后热敏灸治疗组与传统艾灸组及空白对照组比较，差异均有统计学意义（P〈0．05或P〈0．01）。结论热敏灸通过对血液流变学的影响，起到促进血液运行、活血化瘀的作用，从而对股骨头缺血性坏死的修复有较好的效果。

火针强通法结合朱琏熨热灸法治疗带状疱疹70例疗效观察

目的:探讨火针强通法结合朱琏熨热灸法治疗带状疱疹的疗效。方法:将140例带状疱疹患者随机分为治疗组和对照组各70例,治疗组采用火针焠刺、拔罐及朱琏熨热灸法,对照组采用火针焠刺疗法进行治疗。2个疗程后评定临床疗效。结果:总有效率治疗组为95.7%,对照组为81.5%,两组比较,差异有统计学意义(P<0.05)。结论:火针强通法结合朱琏熨热灸法治疗带状疱疹的疗效优于单纯火针焠刺疗法。

热灸对直结肠伤害性扩张抑制效应的脊髓机制研究

目的:探讨热灸法缓解内脏痛的机制及其影响因素。方法:选用SD大鼠采用直结肠扩张法(CRD)作为伤害性刺激。微电极细胞外记录L1～L3节段脊髓背角广动力型(WDR)神经元活动。不同参数的热灸作用于非感受野"承扶"穴。结果:直结肠的伤害性传入能明显激活脊髓背角会聚神经元,对侧非感受野穴位的特定参数的热灸刺激能明显抑制这种伤害性反应。结论:来自体表的热灸与直结肠的伤害性传入信号在脊髓水平发生会聚,而特定参数的热灸能够抑制直结肠的伤害性传入所激活的脊髓背角神经元反应。

灸法临证经验举要

灸法为灼体疗病之意。本文介绍作者惯用之热熨灸法、点按灸法、药锭灸法、药线灸法、贴棉灸法和拍打灸法 ,分述其药物组成、制作方法、功效、主治病证、使用方法和方解 ,并各附病案 1则 。

灸法结合热奄包对轻型颅脑损伤患者缓解头痛的疗效观察

目的观察灸法结合中药热奄包对轻型颅脑损伤患者缓解头痛的临床疗效 .方法：80 例患者随机分成灸法结合中药热奄包治疗组（简称观察组即A 组）40 例、对照组（B 组）40 例.A 组病人在入院后第二天除常规治疗外另即给予中医辩证,并开具灸疗结合热奄包治疗.B 组病人达到疼痛评分则口服止痛药止痛.结果：观察组和对照组比较,观察组的头痛缓解明显优于对照组,差异有统计学意义（P〈0.05）.结论：灸法结合热奄包对轻型颅脑损伤患者头痛缓解有明显的疗效,是一种简单、有效的护理方法.

不同表面积和不同温度的热灸样刺激对大鼠延髓背侧网状亚核神经元的激活作用

目的:探讨热灸法的作用机制及最佳的热灸刺激参数。方法:选用SD大鼠15只,微电极胞外记录延髓背侧网状亚核(SRD)神经元活动,观察7种不同温度(40、42、44、46、48、50、52℃)和7种不同圆形面积(直径分别为1.0、1.5、2.0、2.5、3.0、3.5、4.0 cm)组成的不同组合的热刺激对SRD神经元放电活动的影响。刺激部位以"中脘"穴为中心,刺激持续时间为30 s。结果:40℃和42℃的热刺激在任何面积下对SRD神经元均无激活作用;44℃-Φ3.5 cm和44℃-Φ4.0 cm的刺激组合对SRD神经元有明显激活作用;温度达46℃以上后,热刺激面积与SRD神经元的放电活动呈线性相关;48℃-Φ3.0 cm、50℃-Φ3.5 cm、52℃-Φ3.5 cm刺激组合达到SRD神经元放电活动的平台期,在温度不变的条件下,SRD神经元放电不再随刺激面积的增大而增加。结论:伤害性范围内的热刺激可以激活SRD神经元,当热刺激达到一定参数后,SRD神经元的激活反应会出现平台期。

Thirty-six cases of functional anorectal pain treated with heat-sensitization moxibustion

Objective To explore the clinical effects of heat-sensitizing moxibustion on functional anorectal pain. Methods Thirty six patients with functional anorectal pain were treated with moxibustion on heat-sensitive acupuncture points.The heat-sensitized points include Chángqiáng（长强 GV l）, Cìliáo（次髎 BL 32）, Yāoshū（腰俞 GV 2）, and local perianal points. A course of treatment consisted of treatment at each heat-sensitized point for 15 min once per day for 10 days. The therapeutic effects were observed after continuous treatment for 3 treatment cycles. Results Twelve cases were cured, eleven cases had effective results, and 3 cases were ineffective. The total effectiveness rate was 91.7%. The visual analog scale（VAS） total score was 6.1±1.52 before treatment and was 1.63±1.05 after treatment, showing a statistically significant difference（P〈0.01）. Conclusion Heat-sensitization moxibustion can significantly relieve functional anorectal pain.

Therapeutic observation on heat-sensitive acupoint for treatment of Irishmen with discogenic low back pain

Objective To observe the therapeutic difference in treatment of Irishmen with discogenic low back pain （arthritis of cold-damp syndrome type） between heat-sensitive acupoint and acupuncture. Methods Eighty-two patients were randomly assigned to the heat-sensitive group （43 cases） and the acupuncture group （39 cases）. Corresponding heat-sensitive points in the lumbosacral area were selected in the heat-sensitive group. Then moxibustion was performed at the heat-sensitive acupoint, thus conducting the moxibustion sensation. The treatment was ended when the sensation conduction was finished. If there appeared no moxibustion sensation, moxibustion at the corresponding painful point was lasted for 30 min. Needling was performed in the acupuncture group at corresponding Jiájǐ（夹 脊 EX-B 2）, Back-shu point, Wěizhōng （委中 BL 40）; matching points included Huántiào （环跳 GB 30）, Fēngshì（风市 GB 31）, Yánglíngquán （阳陵泉 GB 34）, Zhìbiān （秩边 BL 54）, etc. The waste was irradiated with TDP after needling, with the maintaining time of 30 min. The treatment was carried out twice weekly, four weeks as one therapeutic course. The therapeutic effect was statistically calculated after 8-week treatment. Results Nineteen cases were clinically cured, 20 improved, 4 failed, and the effective rate 90.7%（39/43） in the heat-sensitive group, while 9 clinically cured, 25 improved, 5 failed, and the effective rate 87.2%（34/39） in the acupuncture group. Signif icant difference was shown in the clinically cured case by 2 test （P0.05）. Conclusion Heat-sensitive acupoint was superior to traditional acupuncture in treatment Irishmen with discogenic low back pain.

Effect of heat-sensitive moxibustion plus psychological intervention on SP, 5-HT and quality of life in patients with irritable bowel syndrome

Objective： To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P（SP） and 5-hydroxytryptamine（5-HT）, as well as the quality of life（QOL） in patients with irritable bowel syndrome（IBS）. Methods： A total of 120 IBS patients were divided into three groups by random sampling method, 40 cases in each group. The heat-sensitive moxibustion group received heat-sensitive moxibustion, the psychological intervention group received psychological intervention, while the observation group received both methods. The therapeutic efficacy was evaluated after 3 courses of treatment. Results： After treatment, the therapeutic efficacy of the observation group was better than that of the heat-sensitive moxibustion group and the psychological intervention group（P〈0.01）, and the heat-sensitive moxibsution group was better than the psychological intervention group（P〈0.05）. In comparing the bowel symptom scale（BSS）, the observation group was better than the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）. In the comparison of QOL, the observation group was significantly superior to the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. In comparing serum SP and 5-HT, the observation group was markedly better than the other two groups（P〈0.05）, and there were significant differences between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. The self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were used to estimate the mental state of the three groups, revealing that the observation group was better than the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）, and there were significant differences between the latter two groups（P〈0.05）. Conclusion： Heat-sensitive moxibustion plus psychological intervention can regulate the levels of SP and 5-HT, improve BSS, SDS, SAS and QOL in treating IBS.

Clinical study on skin needling plus heat-sensitive moxibustion for chronic facial paralysis

Objective：To observe the clinical efficacy of skin needling plus heat-sensitive moxibustion in treating chronic facial paralysis. Methods：Sixty patients with chronic facial paralysis were divided into an observation group and an acupuncture group by using the random number table, 30 in each group. Patients in the observation group were given skin needling plus heat-sensitive moxibustion; while patients in the acupuncture group were given conventional acupuncture. Results：Three treatment courses later, the total effective rate was 93.3% in the observation group versus 86.7% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion：Skin needling plus heat-sensitive moxibustion can produce a more significant efficacy than conventional acupuncture in treating chronic facial paralysis.

Clinical observation on heat-sensitive moxibustion plus lactulose for postoperative constipation of mixed hemorrhoid due to spleen deficiency

Objective:To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods:A total of 70 patients were randomized into a treatment group and a control group,with 35 cases in each group by a random number table.Patients in the control group received lactulose oral liquid alone,while those in the treatment group received additional heat-sensitive moxibustion at Shenque(CV 8).The treatment was given once a day for 15 consecutive days.The defecation interval time,defecation duration,the scores of stool form,visual analog scale(VAS)and patient assessment of constipation quality of life questionnaire(PAC-QOL),as well as the serum substance P(SP)and nitric oxide(NO)levels were measured before and after treatment.Results:After treatment,the stool form score,defecation interval time and defecation duration in the two groups dropped significantly(all P<0.05),and they were lower in the treatment group than in the control group(all P<0.05).After treatment,the VAS scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the PAC-QOL scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the serum SP and NO levels in the two groups improved significantly(all P<0.05),and showed statistically significant differences between the treatment group and the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus lactulose oral liquid can improve stool form,shorten defecation interval time and defecation duration,alleviate defecation pain,and improve quality of life(QOL)for patients with postoperative constipation of mixed hemorrhoid,which may be related to the regulation of the SP and NO levels.

Therapeutic observation of acupuncture plus heat-sensitive moxibustion for chronic pelvic inflammatory disease

Objective：To observe the therapeutic efficacy of acupuncture plus heat-sensitive moxibustion in treating chronic pelvic inflammatory disease （CPID）, for selecting an effective acupuncture-moxibustion method in treating chronic pelvic inflammation. Methods：Eighty CPID subjects were enrolled and divided into two groups by randomized single-blind method, 40 in each group. The observation group was intervened by acupuncture plus heat-sensitive moxibustion, while the control group was by acupuncture plus box-moxibustion, once every other day, 10 sessions as a treatment course, but the period time was skipped. The therapeutic efficacy was observed after 3 treatment courses. Results：The recovery rate was 45.0% and the total effective rate was 95.0% in the observation group, versus 20.0% and 80.0% in the control roup. There were significant differences in comparing the recovery rate and the total effective rate between the two groups （P〈0.05）. Conclusion：Acupuncture plus heat-sensitive moxibustion can produce a higher therapeutic efficacy in treating CPID than acupuncture plus box-moxibustion, and this is an easy-to-operate and safe method without adverse effect.

Effect of heat-sensitive moxibustion on facial function score in patients with facial paralysis

Objective： To observe and compare the therapeutic efficacies of heat-sensitive moxibustion plus Western medication, dry Western medication, and acupuncture plus TDP in treating peripheral facial palsy （FP）. Methods： Ninety FP patients were randomized into a Western medication group, a heat-sensitive moxibustion group, and an acupuncture group by using sealed envelope, 30 cases in each group. The Western medication group was intervened by conventional Western medication; the heat-sensitive moxibustion group was by heat-sensitive moxibustion in addition to the same Western medication; the acupuncture group was by the Western medication plus acupuncture and TDP radiation. For the three groups, 6-day treatment was taken as a treatment course, with a 2-day interval between 2 courses, and totally 4 treatment courses were observed. Results： After intervention, the modified Portmann scores were changed significantly in the three groups （P〈0.05）, and the improvements in the heat-sensitive moxibustion group and the acupuncture group were both superior to that in the Western medication group. The recovery plus markedly effective rate of the acupuncture group was significantly different from that of the Western medication group （P〈0.05）, and there was a significant difference in comparing the recovery plus markedly effective rate between the heat-sensitive moxibustion group and acupuncture group （P〈0.05）. Conclusion： Heat-sensitive moxibustion is effective in treatment peripheral facial paralysis, and this method is free of pain, causing no adverse reactions, and worth promotion in clinic.

Effect observation on heat-sensitive moxibustion for cervical spondylosis of vertebral artery type

Objective： To observe the difference of the therapeutic effect between heat-sensitive moxibustion and warm needling therapy for cervical spondylosis of vertebral artery type （CSA）. Methods： A total of 60 cases with CSA who met the inclusion criteria were randomly divided into a heat-sensitive moxibustion （HSM） group and a warm needling therapy （WNT） group according to the visiting sequences, with 30 cases in each group. Patients in the former group were treated by heat-sensitive moxibustion, while patients in the latter group were treated by warm needling therapy. Both groups were treated once every other day, with 10 times as 1 course of treatment, and the therapeutic effects were evaluated after I course of treatment. Results： After 1 course of treatment, the total effective rate of the HSM group was 93.3%, versus 83.3% in the WNT group. There was a statistically significant difference between the two groups （P〈0.05）. Conclusion： Heat-sensitive moxibustion has better therapeutic effect for CSA than warm needling therapy.

Therapeutic efficacy of moxibustion plus medicine in the treatment of infertility due to polycystic ovary syndrome and its effect on serum immune inflammatory factors

Objective:To explore the effects and related mechanism of heat-sensitive moxibustion plus clomifene citrate capsules for infertility due to polycystic ovary syndrome(PCOS).Methods:A total of 70 patients were randomized into a control group and an observation group by the random number table method,with 35 cases in each group.The control group was treated with clomifene citrate capsules,while the observation group was treated with heat-sensitive moxibustion on the basis of the medications in the control group.The treatment course lasted for 6 menstrual cycles.The endometrial thickness and ovarian volume of the patients were measured before and after treatment.The levels of serum sex hormones,tumor necrosis factor-α(TNF-α)and nuclear factor-κB(NF-κB)were detected.Follow-up was performed for 1 year after treatment,and the pregnancy rate was recorded.Results:After treatment,the endometrium of the patients in both groups was significantly thickened,the ovarian volume was significantly reduced,and the intra-group differences were statistically significant(all P<0.05).The endometrium thickness and ovarian volume in the observation group were significantly different from those in the control group(both P<0.05).After treatment,the levels of serum testostrn(T)and luteinizing hormone(LH)in both groups decreased significantly,the level of estradiol(E2)increased obviously,and the intra-group differences were statistically significant(all P<0.05).The levels of serum T and LH in the observation group were lower than those in the control group,and the E2 level in the observation group was higher than that in the control group,and the between-group differences were statistically significant(all P<0.05).After treatment,the levels of serum TNF-αand NF-κB of the patients in both groups decreased,and the intra-group differences were statistically significant(all P<0.05).The levels of serum TNF-αand NF-κB in the observation group were significantly lower than those in the control group(both P<0.05).After 1-year follow-up,the pregnancy rate was 20.0%in the control group,versus 51.5%in the observation group.The pregnancy rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The treatment of heat-sensitive moxibustion plus clomifene citrate capsules can increase the endometrium thickness,reduce the ovarian volume,improve the status of serum sex hormone disorders,and increase the conception rate in patients with infertility due to PCOS,which may be related to the adjustment of the levels of immune inflammatory factors such as serum TNF-αand NF-κB.

Irritable bowel syndrome with diarrhea (IBS-D) treated with moxibustion on heat-sensitive acupoints: a randomized controlled trial

Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly divided into an acupuncture and moxibustion group （n=32） and an acupuncture group （n=32）. Conventional acupuncture at Tiānshū （天枢 ST 14）, Zúsānlǐ （足三里 ST 36）, Gōngsūn （公孙 SP 4） and other acupoints was used in the two groups, and moxibustion on heat-sensitive acupoints was added in the acupuncture and moxibustion group. The treatment frequency was 5 times a week, and 4 weeks were a course. After 2 courses, the therapeutic effect was evaluated. Results The clinical symptom scores after treatment in two groups decreased obviously than those before treatment （both P〈0.01）. The cured and markedly effective rate in the acupuncture and moxibustion group was 87.5% （28/32）, and that in the acupuncture group was 37.5% （12/32）, so the effect in the acupuncture and moxibustion group was better than that in the acupuncture group （P〈0.01）. The improvement of all kinds of symptom scores in the acupuncture and moxibustion group was all better than that in the acupuncture group （all P〈0.05）. Conclusion The clinical effect of acupuncture combined with moxibustion on heat-sensitive acupoints on IBS-D is better than that of acupuncture.

Clinical observation of heat-sensitive moxibustion for acute ischemic stroke

Objective To observe the clinical efficacy of heat-sensitive moxibustion in intervening acute ischemic stroke.Methods A total of 112 patients were divided into a control group and an observation group by the random number table method,with 56 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control group.The National Institute of Health stroke scale(NIHSS)and modified Barthel index(MBI)were evaluated,and the intracranial hemodynamic indicators including mean velocity(Vm),pulsatility index(PI)and resistance index(RI)were recorded,and the serum levels of superoxide dismutase(SOD)and homocysteine(HCY)were measured before and after treatment.Clinical efficacy was evaluated after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the NIHSS scores in both groups decreased significantly(both P<0.05),and the MBI scores increased significantly(both P<0.05).The improvements of NIHSS and MBI scores in the observation group were superior to those in the control group(both P<0.05).Vm in both groups increased significantly(both P<0.05),PI and RI decreased(all P<0.05),and Vm,PI and RI in the observation group were superior to those in the control group(all P<0.05).The serum levels of SOD and HCY in the observation group were significantly improved,and were statistically different from those in the control group(both P<0.05).Conclusion Conventional treatment plus heat-sensitive moxibustion is effective in intervening acute ischemic stroke.It can promote the recovery of neurological function,improve daily activities,and improve intracranial blood flow,which may be related to the regulation of serum SOD and HCY levels.

Clinical observation of tuina plus heat-sensitive moxibustion for temporomandibular disorders

Objective： To observe the clinical efficacy of tuina plus heat-sensitive moxibustion in treating temporomandibular disorders （TMD）. Methods： Fifty patients with TMD were randomized into a treatment group and a control group, 25 cases in each group. The treatment group was intervened by tuina plus heat-sensitive moxibustion, while the control group was by medication. The Fricton-Shiffman craniomandibular index （CMI） was observed before and after intervention, and the clinical efficacies of the two groups were also evaluated. Results： There was no significant difference in comparing the CMI score between the two groups before intervention （P^0.05）. After a treatment course, there were significant improvements in evaluating the CMI score in both groups （P^0.01）, and the improvement was more significant in the treatment group than that in the control group （P〈0.01）. The total effective rate of the treatment group was significantly higher than that of the control group （P〈0.01）. Conclusion： Tuina plus heat-sensitive moxibustion is effective in treating TMD, and it＇s safe, without adverse reactions, thus worth promoting in clinic.