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烯二炔类抗肿瘤抗生素全合成研究Ⅱ.抗生素C-1027a发色团烯二炔单元开链衍生物的合成 被引量:3
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作者 朱锦桃 郭惠元 +1 位作者 李卓荣 张致平 《中国抗生素杂志》 CAS CSCD 北大核心 1998年第6期425-430,共6页
以卤代环戊烯酮1或2出发,经5步反应,制得了烯炔醛化合物12,再与由膦叶立德19出发,经4步反应制备的碘代烯炔15反应,生成了具有与环戊烯共轭骈连的烯二炔结构的目标化合物16。它脱保护后,得到了抗肿瘤抗生素C-102... 以卤代环戊烯酮1或2出发,经5步反应,制得了烯炔醛化合物12,再与由膦叶立德19出发,经4步反应制备的碘代烯炔15反应,生成了具有与环戊烯共轭骈连的烯二炔结构的目标化合物16。它脱保护后,得到了抗肿瘤抗生素C-1027发色团及kedarcidine发色团中烯二炔单元的开链衍生物17。 展开更多
关键词 烯二烯类 抗肿瘤抗生素 C-1027发色团 合成
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The effects of season on fatty acid composition and ω3/ω6 ratios of northern pike(Esox lucius L.,1758) muscle lipids 被引量:1
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作者 MERT Ramazan BULUT Sait KONUK Muhsin 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2015年第1期70-76,共7页
In the present study, the effects of season on fatty acid composition, total lipids, and ω3/ω6 ratios of northern pike muscle lipids in Klzlhrmak River (Klrlkkale, Turkey) were investigated. A total of 35 differen... In the present study, the effects of season on fatty acid composition, total lipids, and ω3/ω6 ratios of northern pike muscle lipids in Klzlhrmak River (Klrlkkale, Turkey) were investigated. A total of 35 different fatty acids were determined in gas chromatography. Among these, palmitic, oleic, and palmitoleic acids had the highest proportion. The main polyunsaturated fatty acids (PUFAs) were found to be docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid. There were more PUFAs than monounsaturated fatty acids (MUFA) in all seasons. Similarly, the percentages of ω3 fatty acids were higher than those of total ω6 fatty acids in the fatty acid composition. ω3/ω6 ratios were calculated as 1.53, 1.32, 1.97, and 1.71 in spring, summer, autumn and winter, respectively. Overall, we found that the fatty acid composition and ω3/ω6 fatty acid ratio in the muscle of northern pike were significantly influenced by season. 展开更多
关键词 freshwater fish fatty acid composition omega-3 PUFA lipid content SEASON
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Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation 被引量:7
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作者 XU Na SHEN Ning +3 位作者 WANG XiuXing JIANG Shan XUE Bin LI ChaoJun 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第4期328-335,共8页
The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophos... The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate(FPP) or geranylgeranyl pyrophosphate(GGPP) as the substrate, respectively. The prenylation occurs by covalent addition of these two types of isoprenoids to cysteine residues at or near the carboxyl terminus of the proteins that possess Caa X motif, such as Ras small GTPase family. The attachment of hydrophobic prenyl groups can anchor the proteins to intracellular membranes and trigger downstream cell signaling pathway. Geranylgeranyl biphosphate synthase(GGPPS) catalyzes the synthesis of 20-carbon GGPP from 15-carbon FPP. The abnormal expression of this enzyme will affect the relative content of FPP and GGPP, and thus disrupts the balance between protein farnesylation and geranylgeranylation, which participates into various aspects of cellular physiology and pathology. In this paper, we mainly review the property of this important protein post-translational modification and research progress in its regulation of cigarette smoke induced pulmonary disease, adipocyte insulin sensitivity, the inflammation response of Sertoli cells, the hepatic lipogenesis and the cardiac hypertrophy. 展开更多
关键词 protein prenylation GGPP FPP biological function regulation
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