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针刺对海洛因成瘾戒断大鼠下丘脑-垂体-肾上腺系统的影响 被引量:12
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作者 王桂华 潘贵书 +1 位作者 郭莉 韩艳春 《中国药理学通报》 CAS CSCD 北大核心 2012年第3期402-406,共5页
目的研究旨在观察针刺对海洛因成瘾戒断大鼠焦虑相关行为是否有作用,并分析其可能机制。方法按逐日递增的原则皮下注射海洛因建立成瘾模型,停止给药后纳洛酮催瘾,建立海洛因成瘾戒断动物模型;连续7 d针刺"神门"穴;通过高架十... 目的研究旨在观察针刺对海洛因成瘾戒断大鼠焦虑相关行为是否有作用,并分析其可能机制。方法按逐日递增的原则皮下注射海洛因建立成瘾模型,停止给药后纳洛酮催瘾,建立海洛因成瘾戒断动物模型;连续7 d针刺"神门"穴;通过高架十字迷宫实验观察戒断大鼠焦虑程度及针刺的抗焦虑作用;以放射免疫分析技术(RIA)测定大鼠血浆中皮质醇(corticosterone,CORT)、促肾上腺皮质激素(adrenocor-ticotropin hormone,ACTH)和精氨酸加压素(arginine vaso-pressin,AVP)水平。应用免疫组织化学检测下丘脑室旁核(paraventricular nucleus,PVN)反应神经元活动度Fos蛋白表达。结果针刺明显增加海洛因成瘾戒断大鼠进入开臂的次数百分率及在开臂滞留时间百分率(P<0.01或P<0.05);放免结果显示针刺降低海洛因成瘾戒断大鼠血浆CORT、ACTH和AVP水平(P<0.01或P<0.05);免疫组化结果显示针刺降低戒断大鼠下丘脑室旁核Fos蛋白表达(P<0.01或P<0.05)。结论针刺降低海洛因成瘾戒断大鼠焦虑程度和调节下丘脑-垂体-肾上腺(hypothalamic-pitui-tary-adrenal,HPA)系统活动,提示针刺可以缓解海洛因成瘾戒断期间所致的情绪异常,其机制可能与调节下丘脑-垂体-肾上腺系统功能有关。 展开更多
关键词 针刺 海洛因成瘾戒断 “神门”穴 焦虑相关症状 下丘脑-垂体-肾上腺系统 室旁核 FOS蛋白
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Performance Anxiety and the Fight or Flight Syndrome
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作者 Dennis Williams 《Journal of Literature and Art Studies》 2012年第5期551-558,共8页
Performance Anxiety is perhaps the most common social fear. Also called Stage Fright, Performance Anxiety is the fear of being in front of an audience, and all of the corollaries that are associated with the condition... Performance Anxiety is perhaps the most common social fear. Also called Stage Fright, Performance Anxiety is the fear of being in front of an audience, and all of the corollaries that are associated with the condition. The condition can be almost debilitating, and is all the more devastating to a seasoned professional performer who continues to be afflicted by the situation. Although there are numerous causes as the root of Performance Anxiety in different people, a significant reason for Performance Anxiety is a behavioral pattern that psychoanalysts call the Fight or Flight Syndrome. This syndrome is the focus of this paper. This paper identifies a number of the symptoms of Performance Anxiety along with many of the false antidotes that are suggested by friends and associates. Evidence is presented to support the realization that most audiences are not the enemy. Recommendations and a treatment plan are suggested which are designed to alleviate Performance Anxiety issues and are based on principles of behavioral modification. 展开更多
关键词 Performance Anxiety Fight or Flight Syndrome panic attack stress disorder AGORAPHOBIA stage fright
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