AIM： To investigate features of Epstein-Barr virus （EBV）associated gastric carcinoma （EBVaGC） among a Mexican population. METHODS： Cases of primary gastric adenocarcinoma were retrieved from the files of the Dep...AIM： To investigate features of Epstein-Barr virus （EBV）associated gastric carcinoma （EBVaGC） among a Mexican population. METHODS： Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of Pathology at the Instituto Nacional de Cancerologia and the Instituto Nacional de la Nutrición in Mexico City. The anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 （EBER-1） in situ hybridization was conducted to determine the presence of EBV in neoplastic cells. RESULTS： We studied 330 consecutive, non-selected, primary gastric carcinomas. Among these, there were 173 male and 157 female patients （male/female ratio 1.1/1）. EBER-1 was detected in 24 （7.3%） cases （male/ female ratio： 1.2/1）. The mean age for the entire group was 58.1 years （range： 20-88 years）, whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years （range： 50-84 years）. Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively. CONCLUSION： Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population 〉50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population.展开更多
In this paper, we use the modified Hod's treatment and the Kunstatter's method to study the horizon area spectrum and entropy spectrum in Gauss-Bonnet de-Sitter space-time, which is regarded as the natural gen...In this paper, we use the modified Hod's treatment and the Kunstatter's method to study the horizon area spectrum and entropy spectrum in Gauss-Bonnet de-Sitter space-time, which is regarded as the natural generalization of Einstein gravity by including higher derivative correction terms to the original Einstein-Hilbert action. The horizon areas have some properties that are very different from the vacuum solutions obtained from the frame of Einstein gravity. With the new physical interpretation of quasinormal modes, the area/entropy spectrum for the event horizon for nearextremal Gauss-Bonnet de Sitter black holes are obtained. Meanwhile, we also extend the discussion of area/entropy quantization to the non-extremal black holes solutions.展开更多
基金Supported by a Grant No. 12218231 from Grants-in-Aid for Scientific Research of the Ministry of Education, Science, Sports,and Culture of Japan
文摘AIM： To investigate features of Epstein-Barr virus （EBV）associated gastric carcinoma （EBVaGC） among a Mexican population. METHODS： Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of Pathology at the Instituto Nacional de Cancerologia and the Instituto Nacional de la Nutrición in Mexico City. The anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 （EBER-1） in situ hybridization was conducted to determine the presence of EBV in neoplastic cells. RESULTS： We studied 330 consecutive, non-selected, primary gastric carcinomas. Among these, there were 173 male and 157 female patients （male/female ratio 1.1/1）. EBER-1 was detected in 24 （7.3%） cases （male/ female ratio： 1.2/1）. The mean age for the entire group was 58.1 years （range： 20-88 years）, whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years （range： 50-84 years）. Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively. CONCLUSION： Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population 〉50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population.
基金Supported by the Natural Science Foundation of China under Grant No.10275030Cuiying Project of Lanzhou University 225000-582404
文摘In this paper, we use the modified Hod's treatment and the Kunstatter's method to study the horizon area spectrum and entropy spectrum in Gauss-Bonnet de-Sitter space-time, which is regarded as the natural generalization of Einstein gravity by including higher derivative correction terms to the original Einstein-Hilbert action. The horizon areas have some properties that are very different from the vacuum solutions obtained from the frame of Einstein gravity. With the new physical interpretation of quasinormal modes, the area/entropy spectrum for the event horizon for nearextremal Gauss-Bonnet de Sitter black holes are obtained. Meanwhile, we also extend the discussion of area/entropy quantization to the non-extremal black holes solutions.
