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影响临时修复体边缘准确性的因素及由此产生的牙周反应 被引量:3
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作者 宋嘉麟 季佩红 +2 位作者 尹吾琛 张捷明 许全林 《口腔材料器械杂志》 2009年第4期196-198,共3页
临时修复体是固定修复中一个重要组成部分,而合适的边缘准确性又是衡量临时修复体的一个重要标准。本文就临床上对边缘准确性产生影响的主要因素以及由不合适的边缘引起的牙周反应作一综述。
关键词 临时修复体 边缘准确性 牙周反应
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全瓷冠与高嵌体对后牙牙体缺损的修复效果及对牙周炎性反应的影响
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作者 龙乐 双娈 +3 位作者 张丽 范莉莎 苏德丽 付鹏 《广州医药》 2024年第3期311-315,共5页
目的分析全瓷冠与高嵌体对后牙牙体缺损的修复效果及对牙周炎性反应的影响。方法用随机抽签法将我科2022年2月—2023年5月接治的50例后牙牙体缺损者分为对照组(签号为奇数,全瓷冠修复)与高嵌体组(签号为偶数,高嵌体修复),各25例,对比两... 目的分析全瓷冠与高嵌体对后牙牙体缺损的修复效果及对牙周炎性反应的影响。方法用随机抽签法将我科2022年2月—2023年5月接治的50例后牙牙体缺损者分为对照组(签号为奇数,全瓷冠修复)与高嵌体组(签号为偶数,高嵌体修复),各25例,对比两组修复效果(指标为修复体佩戴时间及总体康复时间)、牙周炎性反应、口腔健康指数及并发症发生率。结果高嵌体组修复体佩戴时间(14.38±2.51)d、总体康复时间为(59.66±4.47)d,短于对照组的(21.96±2.87)d、(93.84±5.26)d(P<0.001);高嵌体组牙周正常率(88.00%)高于对照组(64.00%)(P<0.05);高嵌体组修复后的GI、PLI、SBI分别为(0.81±0.19)分、(0.85±0.16)分、(1.04±0.25)分,低于对照组的(0.97±0.23)分、(1.01±0.22)分、(1.31±0.28)分(P<0.05);高嵌体组并发症发生率(8.00%)接近于对照组(12.00%)(P>0.05)。结论修复后牙牙体缺损时选用高嵌体修复法可取得相对更好的修复效果,能够缩短患者佩戴修复体时间,加速其康复进程,对牙周炎性反应的减轻、口腔健康的改善均有积极影响,且并发症风险较小,整体效果更优。 展开更多
关键词 全瓷冠 高嵌体 后牙牙体缺损 修复效果 牙周炎性反应
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培氟沙星与盐酸米诺环素联合治疗慢性牙周炎的临床效果及对患者牙周炎性反应的影响
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作者 李文萍 陈萌萌 《临床医学工程》 2024年第6期695-696,共2页
目的分析培氟沙星联合盐酸米诺环素治疗慢性牙周炎(CP)的效果。方法86例CP患者随机分为两组,对照组予以盐酸米诺环素治疗,观察组在对照组基础上予以培氟沙星治疗,比较两组的临床疗效、牙周炎性反应以及牙周健康状况。结果治疗后,观察组... 目的分析培氟沙星联合盐酸米诺环素治疗慢性牙周炎(CP)的效果。方法86例CP患者随机分为两组,对照组予以盐酸米诺环素治疗,观察组在对照组基础上予以培氟沙星治疗,比较两组的临床疗效、牙周炎性反应以及牙周健康状况。结果治疗后,观察组的总有效率高于对照组,TNF-α、hs-CRP、IL-1β水平以及SBI、PLI、GI、PD均低于对照组(P<0.05)。结论培氟沙星联合盐酸米诺环素可提高CP治疗效果,减轻患者牙周炎性反应,改善牙周健康度。 展开更多
关键词 慢性牙周 培氟沙星 盐酸米诺环素 牙周炎性反应
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miR-142-3p通过靶向IRAK1抑制LPS诱导人牙周膜细胞的炎症反应 被引量:4
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作者 呼海燕 王军强 《上海口腔医学》 CAS CSCD 2016年第6期682-687,共6页
目的 :研究miR-142-3p过表达对脂多糖(LPS)诱导人牙周膜细胞(h PDLCs)分泌炎症因子的影响及其作用机制。方法:组织块法培养原代正常hPDLCs,以不同浓度的LPS处理hPDLCs 6、12、24和48 h;ELISA检测miR-142-3p mimics对2.0μg/mL LPS诱导的... 目的 :研究miR-142-3p过表达对脂多糖(LPS)诱导人牙周膜细胞(h PDLCs)分泌炎症因子的影响及其作用机制。方法:组织块法培养原代正常hPDLCs,以不同浓度的LPS处理hPDLCs 6、12、24和48 h;ELISA检测miR-142-3p mimics对2.0μg/mL LPS诱导的hPDLCs作用24 h后炎症因子(TNF-α、IL-6及IL-1β)的表达情况;双荧光素酶报告基因检测miR-142-3p与白介素1受体相关激酶1(interleukin-1receptor-associated-1 kinase1,IRAK1)的靶标关系,qRT-PCR检测miR-142-3p和IRAK1 mRNA的表达水平,Western印迹法检测IRAK1、Toll样受体4(toll like receptor 4,TLR4)及核因子κB(nuclear factor-κB,NF-κB)的蛋白表达水平。采用SPSS 16.0软件包对数据进行统计学分析。结果:2.0μg/mL LPS作用24 h后,hPDLCs表达miR-142-3p最低,存在显著差异(P<0.01);加入miR-142-3p mimics后,miR-142-3p表达量显著升高(P<0.01);miR-142-3p过表达显著降低了炎症因子(TNF-α、IL-6及IL-1β)的表达水平(P<0.05);双荧光素酶报告基因检测结果显示,miR-142-3p与IRAK1存在直接的靶标关系;miR-142-3p过表达可抑制IRAK1蛋白的表达水平(P<0.05),但对IRAK1 mRNA表达水平无显著影响(P>0.05);Western印迹结果显示,miR-142-3p过表达显著下调TLR4蛋白和NF-κB蛋白磷酸化表达水平(P<0.05)。结论:miR-142-3p过表达可减轻LPS诱导的hPDLCs炎症反应,其机制可能通过靶向抑制IRAK1进而抑制TLR4/NF-κB炎症信号通路,从而发挥对牙周组织的保护作用。 展开更多
关键词 miR-142-3p 牙周膜细胞:炎症反应
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牙齿向牵引——保留牙根的新方法 被引量:2
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作者 李俊 程祥荣 黄翠 《国外医学(口腔医学分册)》 2004年第2期163-164,共2页
为提高修复体的美观和功能熏临床医师希望尽可能保留牙根。本文综述了一种保留牙根的新方法———牙齿向牵引,归纳了其适应征、优点、牙周反应、生物力学反应等方面的问题。
关键词 牙齿He向牵引 牙根 生物力学 牙周反应 适应征
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Influence of Perioperative Blood Transfusion on Prognosis in Patients with Colon Cancer 被引量:3
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作者 LIANG Han WANG Xiaona WANG Baogui PAN Yuan LIU Ning WANG Dianchang HAO Xishan 《The Chinese-German Journal of Clinical Oncology》 CAS 2006年第4期261-267,共7页
Objective: To explore the influence of perioperative blood transfusion on the postoperative survival of patients with colon cancer. Methods: Univariate and multivariate retrospective analyses were performed on the s... Objective: To explore the influence of perioperative blood transfusion on the postoperative survival of patients with colon cancer. Methods: Univariate and multivariate retrospective analyses were performed on the survival in a total of 723 colon cancer patients which were treated surgically during a period of 10 years. Results: Kaplan-Meier estimates showed that more than 800 mL perioperative blood transfusion was the survival predictor. Blood transfusion influenced significantly the prognosis of patients 40 years old and younger, those undergoing helicoloectomy left side, those with papillary adenocarcinoma, those with big tumors (diameter ≥ 8 cm), those with stage Ⅰ tumors, those with lymphatic node metastases and those without liver metastases. In multivariate analysis only the tumor location, radicality of operation, lymphatic invasion, liver metastasis, depth of tumor invasion and TNM stage retained their significance. Conclusion: Perioperative blood transfusion is some extent. The indication of blood transfusion the prognostic factor for patients with colon cancer to must be restricted strictly, specially in patients younger than 40 years old, with right side lesion, papillary adenocarcinoma, big tumors (diameter ≥8 cm), stage Ⅰ tumors and lymphatic node metastases or without liver metastases. But perioperative blood transfusion may not be deleterious for patients with staging Ⅳ disease and with distant metastases. 展开更多
关键词 CANCER COLON SURGERY blood transfusion PROGNOSIS
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Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus 被引量:12
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作者 Ines Gockel Kathrin Dirksen +1 位作者 Claudia M Messow Theodor Junginger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第23期3746-3750,共5页
AIM: C-reactive protein (CRP) is an acute-phase reactant and a known indicator of the malignant potential of the tumour. The aim of this study was to investigate the significance of preoperative CRP as a parameter ... AIM: C-reactive protein (CRP) is an acute-phase reactant and a known indicator of the malignant potential of the tumour. The aim of this study was to investigate the significance of preoperative CRP as a parameter of the perioperative course and long-term prognosis in patients with squamous cell carcinoma and aclenocarcinoma of the oesophagus. METHODS: Serum CRP was determined preoperatively in 291 of 371 patients undergoing oesophagectomy for cancer from December 1989 to March 2004. Median patient age was 59 (28-79) year, 82.5% of patients were males. Squamous cell carcinoma was diagnosed in 151 (51.9%) and aclenocarcinoma in 122 patients. Transhiatal oesophagectomy was clone in 151 (51.9%) patients and 134 (46.0%) patients underwent the abclominothoracic procedure. RESULTS: In 127 (43.6%) patients the preoperative serum CRP concentration was within the normal range (〈 5 mg/clL), elevated CRP levels were measured in 164 (56.4%) patients. Tumour extension (P 〈 0.0005) and the number of lymph nodes affected by metastatic spread (P = 0.015) were significantly increased in the group with elevated CRP levels. Among the perioperative parameters both the number of blood transfusions (P = 0.006) and the general complication rate (P = 0.002) were higher in patients with elevated preoperative CRP levels. The long-term survival rate of 13.6 (0-109.8) mo was poorer in the group with elevated CRP levels compared to 18.9 (0-155.4) mo in the group with normal CRP levels (log-rank test: P = 0.107). Multivariateanalysis with backward variables selection identified preoperative CRP as an independent prognostic factor of the long-term prognosis in patients with oesophageal carcinoma, with a hazard ratio of 1.182 (95% confidence interval: 1.030-1.356). CONCLUSION: The preoperative serum CRP-level is an easily determined independent prognostic marker in patients with squamous cell carcinoma and adenocarcinoma of the oesophagus. 展开更多
关键词 Preoperative C-reactive protein Perioperativecourse Long-term prognosis Squamous cell carcinoma Aclenocarcinoma OESOPHAGUS
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Infection frequency of Epstein-Barr virus in subgingival samples from patients with different periodontal status and its correlation with clinical parameters
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作者 WU Yan-min YAN Jie +2 位作者 CHEN Li-li SUN Wei-lian GU Zhi-yuan 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2006年第11期876-883,共8页
Objective: To detect the infection frequencies of different genotypes of Epstein-Barr virus (EBV) in subgingival samples from chronic periodontitis (CP) patients, and to discuss the correlation between infection with ... Objective: To detect the infection frequencies of different genotypes of Epstein-Barr virus (EBV) in subgingival samples from chronic periodontitis (CP) patients, and to discuss the correlation between infection with EBV and clinical pa-rameters. Methods: Nested-PCR assay was used to detect EBV-1 and EBV-2 in subgingival samples from 65 CP patients, 65 gingivitis patients and 24 periodontally healthy individuals. The amplicons were further identified by restriction fragment length polymorphism analysis (RFLP) with endonucleases Afa I and Stu I. Clinical parameters mainly included bleeding on probing (BOP), probing depth (PD), attachment loss (AL) in six sites of the dentition. Results: In CP patients, gingivitis and periodontally healthy individuals, the infection frequencies were 47.7%, 24.6% and 16.7% for EBV-1, and 15.4%, 7.7% and 0% for EBV-2, respectively. In 2 out of the 65 CP patients co-infection of EBV-1 and EBV-2 was found. The positive rate of EBV-1 in chronic periodontitis patients was higher than that in gingivitis patients (P=0.01) and periodontally healthy individuals (P=0.01). But no significant difference was shown in EBV-1 frequency between gingivitis patients and healthy individuals (P>0.05) or in EBV-2 frequency among the three groups (P>0.05). In CP patients, higher mean BOP value was found in EBV-1 or EBV-2 positive patients than that in EBV negative ones (P<0.01), but with no statistical difference in the mean PD or AL value between EBV positive and negative patients (P>0.05). After initial periodontal treatment, 12 out of the 21 EBV-1 positive CP patients did not show detectable EBV-1 in subgingival samples. Conclusion: nPCR plus RFLP analysis is a sensitive, specific and stable method to detect EBV-1 and EBV-2 in subgingival samples. Subgingival infection with EBV-1 is closely associated with chronic perio-dontitis. Infection of EBV in subgingival samples was correlated with BOP. 展开更多
关键词 PERIODONTITIS Polymerase chain reaction Epstein-Barr virus POLYMORPHISM Restriction fragment length
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