期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
负载丹参酮ⅡA的工程化牛奶外泌体对动脉粥样硬化中巨噬细胞自噬的影响
1
作者 何尤夫 钱宇 吴强 《医药前沿》 2023年第23期9-18,22,共11页
目的:研究负载丹参酮ⅡA的工程化牛奶外泌体对于动脉粥样硬化(AS)中巨噬细胞自噬的影响,探讨其潜在机制。方法:采用高脂喂养构建AS小鼠模型,同时使用ox-LDL构建巨噬细胞泡沫化模型。分别予以丹参酮ⅡA和负载丹参酮ⅡA的工程化牛奶外泌... 目的:研究负载丹参酮ⅡA的工程化牛奶外泌体对于动脉粥样硬化(AS)中巨噬细胞自噬的影响,探讨其潜在机制。方法:采用高脂喂养构建AS小鼠模型,同时使用ox-LDL构建巨噬细胞泡沫化模型。分别予以丹参酮ⅡA和负载丹参酮ⅡA的工程化牛奶外泌体进行治疗,通过相应方法评估AS斑块大小、脂代谢情况、细胞自噬相关蛋白表达情况,以及各组中miR-214-3p的表达情况。随后使用模拟物过表达miR-214-3p后评估自噬相关蛋白表达以及对MAPK/mTOR通路的影响。结果:负载丹参酮ⅡA的工程化牛奶外泌体可明显改善AS小鼠体内脂代谢和AS斑块形成,并可促进ox-LDL诱导的巨噬细胞自噬相关蛋白ATG16L1、Beclin-1表达以及上调LC3Ⅱ/I比值,同时还可抑制巨噬细胞内miR-214-3p表达,其具体机制或与MAPK/mTOR通路有关。结论:负载丹参酮ⅡA的工程化牛奶外泌体可通过miR-214-3p促进巨噬细胞自噬,进而改善AS小鼠体内脂代谢和AS斑块形成,且其效果明显优于单纯使用丹参酮ⅡA。 展开更多
关键词 动脉粥样硬化 丹参酮ⅡA 工程牛奶外泌体 MAPK/mTOR通路 miR-214-3p 巨噬细胞 自噬
下载PDF
“有抗奶”:营养背后是隐忧
2
作者 郑小玲 盖东海 《安全与健康》 2002年第03S期6-7,共2页
提起牛奶工程,都知道业界有一种传说:日本战后经济拮据,但还是拿出钱来给孩子喝牛奶.喝牛奶长大后的这一代日本人身强体壮、智慧过人,不仅从身高、体形上改变了以往日本人矮小、瘦弱的特点,也成为振兴日本经济的主力军.
关键词 “有抗奶” 营养 奶制品 牛奶工程
下载PDF
杨文俊和他的送奶伙伴们
3
作者 张伟 《中国经济周刊》 2007年第24期49-49,共1页
联想、微软、NBA、华润万家、家乐福、新浪、国家体育总局…… 他们聚在一起做什么? 送奶。
关键词 国家体育总局 NBA 家乐福 新浪 杨文俊 牛奶希望工程
下载PDF
AQUAREL: Project Aimed at Improving Water Management in French Dairy Plants
4
作者 Brice Bourbon Jennifer Huet 《Journal of Food Science and Engineering》 2018年第3期137-142,共6页
The AQUAREL project was launched in 2015 by the CNIEL (French Dairy Interbranch Orgainzation) to propose solutions to dairy processors for the development of water reuse scenarios on their plants. The project focuse... The AQUAREL project was launched in 2015 by the CNIEL (French Dairy Interbranch Orgainzation) to propose solutions to dairy processors for the development of water reuse scenarios on their plants. The project focused particularly on the valorization of water from milk which is water obtained during concentration and evaporation processes of milk and its by-products. Firstly, a literature review was done to identify the current uses of water from milk on French plants but also on foreign sites, the technologies used to treat it and the regulations related to water reuse in food industry. Secondly, a field survey was led to establish an overview of the water consumptions and practices existing on the plants. Then, samples were collected on five dairy plants in order to determine the physico-chemical and microbiological composition of water from milk. Thus, the important collection of results obtained was used as a basis for exchanges with water treatment equipment suppliers in order to identify the suitable technologies to treat and reuse water from milk. Two treatment channels were identified, each of them including a filtration and a disinfection step. All this work led to the writing of reports which are now available for the dairy sector professionals. 展开更多
关键词 Water from milk water reuse treatment technologies
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部