Objective. In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)s polymorphic changes in psoriasis vulgaris. Methods.We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP. Result...Objective. In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)s polymorphic changes in psoriasis vulgaris. Methods.We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP. Results.Genotype frequencies of the psoriastics were C/C=20.15%,C/T=48.72% and T/T= 30.77%; the allelic frequencies were C=0.4487 and T=0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control group by X2 test. Conclusion.C677V mutant of MTHFR might be related with psoriasis.展开更多
文摘Objective. In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)s polymorphic changes in psoriasis vulgaris. Methods.We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP. Results.Genotype frequencies of the psoriastics were C/C=20.15%,C/T=48.72% and T/T= 30.77%; the allelic frequencies were C=0.4487 and T=0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control group by X2 test. Conclusion.C677V mutant of MTHFR might be related with psoriasis.
