We read with great interest the recent review by Rodrigo on the celiac disease （CD）. The author analyzed all aspects of CD. Contrary to common belief, this disorder is a systemic disease, rather than a pure digestiv...We read with great interest the recent review by Rodrigo on the celiac disease （CD）. The author analyzed all aspects of CD. Contrary to common belief, this disorder is a systemic disease, rather than a pure digestive alteration. In fact, CD is associated with several diseases： skin manifestations, endocrine disorders, iron-deficiency anemia, osteoporosis, hypertransaminasemia, neurologic disorders and cancer. In the description of skin manifestations, the author reported the association between CD and dermatitis herpetiformis （DH）. This condition affects about 15%-25% of patients with CD. Antibodies for CD have been detected in patients with DH. As CD and DH may be vastly different, they both share a unique intestinal sensitivity to gluten. The rash of DH is thought to be an external marker of the underlying intestinal sensitivity that is likely to be the result of molecular mimicry between the auto-antigen tissue transglutaminase resident in the gut and the skin derived epidermal transglutaminase[3]. However, our study group has reported all CD-associated skin manifestations described in the literature, and in particular psoriasis.展开更多
文摘We read with great interest the recent review by Rodrigo on the celiac disease （CD）. The author analyzed all aspects of CD. Contrary to common belief, this disorder is a systemic disease, rather than a pure digestive alteration. In fact, CD is associated with several diseases： skin manifestations, endocrine disorders, iron-deficiency anemia, osteoporosis, hypertransaminasemia, neurologic disorders and cancer. In the description of skin manifestations, the author reported the association between CD and dermatitis herpetiformis （DH）. This condition affects about 15%-25% of patients with CD. Antibodies for CD have been detected in patients with DH. As CD and DH may be vastly different, they both share a unique intestinal sensitivity to gluten. The rash of DH is thought to be an external marker of the underlying intestinal sensitivity that is likely to be the result of molecular mimicry between the auto-antigen tissue transglutaminase resident in the gut and the skin derived epidermal transglutaminase[3]. However, our study group has reported all CD-associated skin manifestations described in the literature, and in particular psoriasis.
