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多西他赛牛血清白蛋白纳米粒的制备及体外评价
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作者 吕鹏 胡荣 +2 位作者 卞玮 杨亚妮 何军 《中国医药工业杂志》 CAS CSCD 北大核心 2017年第7期1030-1034,共5页
采用Nab^(TM)技术制备载多西他赛的牛血清白蛋白纳米粒,以粒径、包封率和载药量为指标,基于单因素试验和正交设计对处方进行优化。并采用动态透析法,考察其体外释放特性。结果表明,多西他赛白蛋白纳米粒优化处方为:牛血清白蛋白1%、氯仿... 采用Nab^(TM)技术制备载多西他赛的牛血清白蛋白纳米粒,以粒径、包封率和载药量为指标,基于单因素试验和正交设计对处方进行优化。并采用动态透析法,考察其体外释放特性。结果表明,多西他赛白蛋白纳米粒优化处方为:牛血清白蛋白1%、氯仿/乙醇比11:1、油/水相比例1:49、药载比1:14.8、水相pH 6.6;制备时乳化均质压力为151.68 MPa,均质25次。照上述优化处方和工艺制备的3批样品平均粒径为(190.10-11.91)nn,包封率为(95.6±0.5)%,载药量(8.1±0.1)%,并具有缓释效果。 展开更多
关键词 多西他赛 牛血清白蛋白纳米粒 Nab^TM技术 处方优化 体外释放
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Roles of Biomolecules in the Biosynthesis of Silver Nanoparticles: Case of Gardenia jasminoides Extract
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作者 吕芬芬 高艺 +2 位作者 黄加乐 孙道华 李清彪 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2014年第6期706-712,共7页
Rapid development of biosynthesis of metal nanoparticles using plants has attracted extensive interests to further investigate this novel and eco-friendly method. In the biosynthesis process, the plant may act as redu... Rapid development of biosynthesis of metal nanoparticles using plants has attracted extensive interests to further investigate this novel and eco-friendly method. In the biosynthesis process, the plant may act as reducing agent, capping agent or shape directing agent. However, identifying specific roles of various components in the plant is challenging. In this study, we use biosynthesis of silver nanoparticles with Gardenia jasminoides Ellis extract to address this issue. The formation process of silver nanoparticles is investigated and the nanoparticles are characterized with the ultraviolet-visible spectroscopy, Fourier transform infrared spectra and scanning electron microscopy. The results indicate that the Gardenia jasminoides Ellis extract can reduce silver ions to form silver nanoparticles, stabilize the nanoparticles, and affect the growth of silver nanocrystal to form silver nanowires. Only geniposide in the extract exhibits good shape-directing ability for silver nanowires. It is found that bovine albumin is a potential capping agent, whereas rutin, gallic acid and chlorogenic acid possess reducing and capping ability. 展开更多
关键词 BIOSYNTHESIS NANOPARTICLE NANOWIRE silver
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