班级物型环境建设的关键词

班级物型环境建设是班级特色文化建设的重要组成部分。下面,我结合自己的带班实践,谈一谈在班级物型环境建设中,班主任要注意的几个关键词。一、关注过程在班级物型环境建设上,学校和班级往往都会统一布置,虽省时、省事,但千篇一律,毫无特色。班级物型环境建设应当是师生共同建设、慢慢设计并逐渐形成影响的过程。

班级物型环境建设要见物更要见人

班级物型环境代表了一种班级文化,其潜在的教育影响力非常大。班主任通过班级物型环境建设,以寓教于物的方式,强化学生的体验,改变学生的认知,引导学生建构自我、改变行为,进而推动学生的全面发展。

为儿童打造一座花园--评《物型课程:教育的空间诗学》

江苏省张家港市实验小学对学校物型环境进行意象化设计,并比喻为“一座小径分岔的花园”,着力打造美学场景、营建诗学空间、构建学校课程,让环境、场域、情景与儿童的学习、生活、生长产生具体联结,凸显儿童主体地位,赋予儿童学习与发现的可能。

A Prognostic Model Based on Colony Stimulating Factors-related Genes in Triple-negative Breast Cancer

Objective Triple-negative breast cancer(TNBC)is the breast cancer subtype with the worst prognosis,and lacks effective therapeutic targets.Colony stimulating factors(CSFs)are cytokines that can regulate the production of blood cells and stimulate the growth and development of immune cells,playing an important role in the malignant progression of TNBC.This article aims to construct a novel prognostic model based on the expression of colony stimulating factors-related genes(CRGs),and analyze the sensitivity of TNBC patients to immunotherapy and drug therapy.Methods We downloaded CRGs from public databases and screened for differentially expressed CRGs between normal and TNBC tissues in the TCGA-BRCA database.Through LASSO Cox regression analysis,we constructed a prognostic model and stratified TNBC patients into high-risk and low-risk groups based on the colony stimulating factors-related genes risk score(CRRS).We further analyzed the correlation between CRRS and patient prognosis,clinical features,tumor microenvironment(TME)in both high-risk and low-risk groups,and evaluated the relationship between CRRS and sensitivity to immunotherapy and drug therapy.Results We identified 842 differentially expressed CRGs in breast cancer tissues of TNBC patients and selected 13 CRGs for constructing the prognostic model.Kaplan-Meier survival curves,time-dependent receiver operating characteristic curves,and other analyses confirmed that TNBC patients with high CRRS had shorter overall survival,and the predictive ability of CRRS prognostic model was further validated using the GEO dataset.Nomogram combining clinical features confirmed that CRRS was an independent factor for the prognosis of TNBC patients.Moreover,patients in the high-risk group had lower levels of immune infiltration in the TME and were sensitive to chemotherapeutic drugs such as 5-fluorouracil,ipatasertib,and paclitaxel.Conclusion We have developed a CRRS-based prognostic model composed of 13 differentially expressed CRGs,which may serve as a useful tool for predicting the prognosis of TNBC patients and guiding clinical treatment.Moreover,the key genes within this model may represent potential molecular targets for future therapies of TNBC.

诗性的空间明亮的童年

江苏省张家港市实验小学主张让儿童“做精神明亮的人——过正常而积极的童年生活”,并基于此打造富有空间诗学的校园物型环境,将美学浸润其中,用心灵化方式运营。一座花园式的学校,与儿童成长紧密相连,为儿童生成了一条从童年通向未来的通道。

“五色”课程:造就“小小研究员”

根据“办真正扎根乡土、走进自然、儿童喜欢的现代化农村小学”的办学愿景,充分挖掘地域课程资源,开发具有鲜明乡村特色的“五色”课程,造就拥有“田野胸怀、劳动精神、探究能力”的“小小研究员”。具体思路为:打造课程物型环境,以“儿童自然科学院”为依托,细化实施“青色”课程、“黄色”课程、“白色”课程、“黑色”课程、“红色”课程,让学生在持续的观察分析、动手实验、亲身体验中提升研究能力。

A New Model on Origin and Evolution of Biology

Modified classical Boltzmann entropy as generalized entropy, then proposed Maximum Generalized Entropy Principle fusing physics and biology, and established a new model for biological origin and evolutions based on this principle, finally took protein evolution for an example to analyze. The model provided some reference for biological complexity research.

Capsella bursa-pastoris extract as an eco-friendly inhibitor on the corrosion of Q235 carbon steels in 1 mol·L^(-1) hydrochloric acid

The corrosion inhibition effect of Capsella bursa-pastoris extracts(CBE) for Q235 carbon steels in 1 mol·L-1hydrochloric acid solution was studied using electrochemical methods, environmental scanning electron microscopy(SEM) and Raman microscopy analysis. The polarization plots indicate that CBE serves as an effective, mixedtype inhibitor. Linear polarization resistance shows that increasing CBE concentration and temperature results in increased inhibition ef ficiency. The highest inhibition ef ficiency can reach 97% when adding 60 mg·L-1CBE,which is better than some reported plant extracts under the similar environment. The adsorption of CBE molecules is found to obey the Langmuir adsorption isotherm. Some thermodynamic and kinetic parameters for the adsorption process, such as the adsorption equilibrium constant(K), free energy of adsorption(ΔG ads), activation energy of corrosion reaction(E a) and the heat of adsorption(Q ads), are calculated and discussed. SEM and Raman microscopy analysis also demonstrate the formation of a CBE inhibition film on the metal surface.

The Characteristic Patterns of Macrofaunal Fouling Assemblages in Nearshore Waters of the South China Sea

The spatio-temporal patterns of macrofaunal fouling assemblages were quantitatively investigated in the nearshore waters of the South China Sea.The work was undertaken by deploying seasonal panels at two sites(H-site,L-site) for one year,and the fouling communities on the panels were examined and analyzed.The results indicated that species composition of assemblages was obviously different between the two sites.At both sites the assemblages were characteristic with solitary dominant species throughout the year,with Amphibalanus reticulates dominating at H-site and Hydroides elegans at L-site.Shannon index and biomass of the assemblages varied with depth and season at both sites.At H-site the total biomass in summer and autumn were significantly higher than those in spring and winter,while at L-site the assemblage biomass also differed significantly among the four seasons,and the greatest biomass occurred at the depth of 2.0 m in winter.The abundance of all seasonal samples in non-metric multidimensional scaling was clustered as one group at L-site and three groups at H-site.The environmental factors were more likely to be related to the variation of fouling assemblages.Furthermore,it also suggests that in tropical seas the integrated adaptability would qualify a species for dominating a fouling assemblage despite its short life cycle,rather than the usually assumed only species with long life span.This study reveals the complexity and characteristic dynamics of macrofaunal fouling assemblages in the tropical habitats,and the results would provide valuable knowledge for biodiversity and antifouling research.

17α-Ethinylestradiol removal from water by magnetic ion exchange resin

Magnetic ion exchange(MIEX) resins have received considerable attention in drinking water treatment due to their fast and efficient removal of dissolved organic carbon(DOC). Two types of mechanisms, i.e., ion exchange,reversible and irreversible adsorption, may occur during pollutants removal by MIEX. This work examined the removal mechanism of 17α-Ethinylestradiol(EE2) by MIEX. As one of typical estrogen micro-pollutants,EE2 existed as neutral molecule in natural water, and its charge density was close to zero [(0.00000219 ±0.00000015) meq·(μg EE2)^(-1)] based on the potentiometric titration method. However, the removal of EE2 by MIEX was much higher than that of other micro-pollutants previously reported. Multi-cycle adsorptionregeneration experiments and ion exchange stoichiometry analysis were conducted to elucidate the removal mechanism of EE2 by MIEX resin. The results suggested that the main removal mechanism of EE2 by MIEX was ion exchange instead of reversible micro-pore adsorption. The experimental analysis based on Donnan theory indicated that the internal micro-environment of resin beads was alkaline, in the alkaline environment EE2 would be ionized into negatively charged groups. As a result, ion exchange reaction occurred inside the pore of MIEX resin, and the removal process of EE2 by MIEX was dominated by the ion exchange reaction.

Biological Autonomy

We argue that genuine biological autonomy, or described at human level as free will, requires taking into account quantum vacuum processes in the context of biological teleology. One faces at least three basic problems of genuine biological autonomy： （1） if biological autonomy is not physical, where does it come from？ （2） Is there a room for biological causes？ And （3） how to obtain a workable model of biological teleology？ It is shown here that the solution of all these three problems is related to the quantum vacuum. We present a short review of how this basic aspect of the fundamentals of quantum theory, although it had not been addressed for nearly 100 years, actually it was suggested by Bohr, Heisenberg, and others. Realizing that the quantum mechanical measurement problem associated with the ＂collapse＂ of the wave function is related, in the Copenhagen Interpretation of quantum mechanics, to a process between self-consciousness and the external physical environment, we are extending the issue for an explanation of the different processes occurring between living organisms and their internal environment. Definitions of genuine biological autonomy, biological aim, and biological spontaneity are presented. We propose to improve the popular two-stage model of decisions with a biological model suitable to obtain a deeper look at the nature of the mind-body problem. In the newly emerging picture biological autonomy emerges as a new, fundamental and inevitable element of the scientific worldview.

Community structure of zooplankton in reef area and its relationship with environmental factors

To better understand the community structure characteristics of zooplankton in the artificial reef area of Tianjin in the Bohai Bay and its relationship with major environmental factors,the project conducted three cruise surveys in the spring(May),summer(July)and autumn(October)of 2016 and monitored conventional environmental factors.The results showed that there were 36 species of zooplankton,including 14 species of copepods,phytoplankton larvae 12 species;6 kinds of coelenterates;3 species of shrimp and 1 species of hairy shrimp in the artificial reef area of Tianjin in the three cruise surveys.The dominant species in spring,summer,and autumn have obvious changes,among which the dominant species in spring are Eurytemora pacifica,Clytia hemisphoerica,Clalnus sinicus,and Macruran larva;in summer are Oithona similis and Brachyura zoea larva;and autumn only the Clalnus sinicus.Correlation analysis shows that the diversity and uniformity of zooplankton in the artificial reef area have increased to varying degrees,indicating that the overall construction of artificial reefs in the Tianjin sea area has improved the marine ecological protection to some extent.The results of CCA showed that salinity and water temperature were the main environmental factors affecting the distribution of zooplankton communities in artificial reefs in Tianjin.

An Alternative-Service Recommending Algorithm Based on Semantic Similarity

With the development of the Internet of Things(Io T), people's lives have become increasingly convenient. It is desirable for smart home(SH) systems to integrate and leverage the enormous information available from IoT. Information can be analyzed to learn user intentions and automatically provide the appropriate services. However, existing service recommendation models typically do not consider the services that are unavailable in a user's living environment. In order to address this problem, we propose a series of semantic models for SH devices. These semantic models can be used to infer user intentions. Based on the models, we proposed a service recommendation probability model and an alternative-service recommending algorithm. The algorithm is devoted to providing appropriate alternative services when the desired service is unavailable. The algorithm has been implemented and achieves accuracy higher than traditional Hidden Markov Model(HMM). The maximum accuracy achieved is 68.3%.

Preliminary bioleaching of heavy metals from contaminated soil employing indigenous Penicillium Chrysogenum strain F1

Bioleaching is an environment-friendly and economical technique to remove heavy metals from contaminated soil.The objective of this work is to find out an indigenous strain to remedy soil contaminated by Zn,Pb,Cu and Cd.A strain which was selected from the soil of a local smelting industry was found to be able to produce many organic acids and degrade pH value of the liquid medium.The fungus strain is identified as Penicillium Chrysogenum (P.Chrysogenum) by sequencing 18srDNA and ITS.Bioleaching condition using P.Chrysogenum is optimized.Glucose is the best carbon source for P.Chrysogenum and inorganic nitrogen is better than organic nitrogen.In addition,neutral solution and room temperature are fit for P.Chrysogenum to bioleach.In the one-step bioleaching,the bioleaching ratios are 39.95% for Zn,9.4% for Pb,34.89% for Cu and 49.59% for Cd,which are 53.89% for Zn,14.44% for Pb,55.53% for Cu and 62.81% for Cd in the two-step bioleaching.The efficiency of two-step bioleaching is better than the one-step bioleaching.P.Chrysogenum is effective in removing heavy metals from the contaminated soil.

Pedestrian environment prediction with different types of on-shore building distribution

The aim of this work is to evaluate how the building distribution influences the cooling effect of water bodies. Different turbulence models, including the S-A, SKE, RNG, Realizable, Low-KE and RSM model, were evaluated, and the CFD results were compared with wind tunnel experiment. The effects of the water body were detected by analyzing the water vapor distribution around it. It is found that the RNG model is the most effective model in terms of accuracy and computational economy. Next, the RNG model was used to simulate four waterfront planning cases to predict the wind, thermal and moisture environment in urban areas around urban water bodies. The results indicate that the building distribution, especially the height of the frontal building, has a larger effect on the water vapor dispersion, and indicate that the column-type distribution has a better performance than the enclosed-type distribution.

Key technologies of precision demolition blasting of ultra-long urban viaduct in complicated surroundings

The key technologies of precision blasting were put forward based on the characteristics of urban via- duct blasting demolition in complicated surroundings. Initial bending instability mechanics model of reinforcing steel bar frame of blasting fragmented pier and sequenced collapsed dynamic model were established for quanti- tative blasting design. Technologies of water pressure blasting were applied in multi-cell box girder fragmenta- tion. The detonating network of non-electric duplication crossover was adopted for the safety and reliability of ultra-long delay. The rationality of blasting scheme and parameters were validated by physical model test. Harm- ful effects were forecasted and controlled by integrated protective technologies. Specialization, cooperation, pre- cision, execution （SCPE） project management method was put forward for precision management. The key tech- nologies of precision demolition blasting can provide reference for similar proiects.

Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters

In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of 2006.We tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological degradation.The taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological indicators.Further application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising.

Research based on the Web Shopping service Quality and Customer Satisfaction and Loyalty

The online shopping has changed people＇s traditional mode of shopping. With more and more customers participate in online shopping, and the online shopping service providers need to improve the quality of service to attract customers to improve customer satisfaction. Based on SERVQUAL model, this paper explores the association between various dimensions of service quality of the web-based shopping and customer satisfaction and service loyalty, and gives an analysis of the five dimensions of quality of service in the context of online shopping, the relationship between service quality and customer satisfaction and loyalty, and thus providing the reference for online shopping service.

Modelling of Baku Residential Structures on a Complex of Climatic Factors

Growth of an anthropogenic load on an environment in the second halfofXXth centuries has led to an exacerbation of many ecological problems. Today ecological risk scales cover territories of large regions. In this respect the territory of Azerbaijan is not exception, within which Baku is noted by very adverse ecological conditions. Complex natural conditions （presence of strong winds, high air temperature and solar radiation） complicate the city ecological situation even greater. In modem conditions a construction boom relates to the factors aggravating the ecological situation of Baku. Last 10 years the city is rapidly built on by multistoried buildings which deform it, hinder visual contacts to the environment and obstruct the natural aeration of Baku amphitheater. The modem multistoried buildings erected ignoring town-planning norms do not correspond with regional climatic conditions, essentially modify the territory wind regime, hamper in surrounding buildings insolation, neglect a territory temperature-humidity conditions. As a result, it is necessary to use energy overly for their adaptation to Baku conditions and creation comfortable microclimate in them that leads to the city environmental pollution. The planning decisions and construction materials applied in these buildings are also alien to Baku climatic conditions. For qualitative transformation of Baku environment and improvement of ecological characteristics of the residential areas the author has carried out the estimation of the city territory on a complex of climatic factors （aeration, insolation and thermal-humidity regimes）. For these purposes the multidimensional statistical method is used. As a result the investigated territory of Baku is divided into 5 typological areas on climatic conditions. The brief characteristic and the general recommendations on transformation are worked out by the author for each of these typological units. Results of the research can be a basis for revealing of methods and principles of town-planning and architectural-planning organization of Baku residential areas.

Nutrient-controlled growth of Skeletonema costatum : an applied model

To model Skeletonema costatum blooms and their relationship with environmental parameters in situ, a S. costatum-specific zero-dimensional box model based on the mechanistic model Eco3M was established using physiological features. The parameters were calibrated using experimental counterparts, and simulations were compared with published laboratory findings. The resulting normalized objective function （NOF） values are less than 1.0 （and in most cases less than 0.58） and the values for the slope y （between 0.656 7-1.127 4） and R2 （between 0.806 8-0.971） are close to 1.0 for most of the sub-figures. This indicates good agreement between simulated and measured data and suggests that the model reproduces the general characteristics of S. costatum growth and use of nutrients under different N- or P-limiting conditions. The model is appropriate for further applications and can be used to test more scenarios using other nutrients.