炼化生产计划优化中的分子建模方法

为了实现生产方案优化,提高石油炼化加工效益,应用模型开展生产计划优化测算是国内外石化企业的普遍做法。当前国内一些企业采用的传统炼化生产计划优化模型比较宏观,无法精确反映原料组分变化对产品收率和性质的影响,因此有必要在优化模型中引入分子管理理念,实现装置的分子水平建模。文章提出一种在全厂炼化计划优化模型中开展分子建模的方法:首先将二次反应装置构建为多个逻辑装置,其次采用多Delta-base结构描述反应后分子产物随原料组分变化的关系,最后采用分方案物性传递技术将分子组分合成为实际产物以实现产品组分的动态计算。该方法在自主研发的国产炼化计划优化软件平台RIPO上实现。采用某企业数据,建立了包括常减压蒸馏、连续重整和芳烃联合装置分子模型的全厂生产计划优化模型。结果表明,该方法可以实现精细化的分子水平建模和优化,优化结果反映了原料组分及加工方案对目标产品收率和性质的影响,为提高炼化经济效益提供了支持。

天然气液化工厂立式虹吸再沸器设计标准要点

立式热虹吸再沸器有具有传热系数较大,结构紧凑,便于安装,投资低等特点。文中结合LNG脱重烃洗涤塔立式虹吸再沸器结构特点,提出相应的设计要点。

3D Photo-Fabrication for Tissue Engineering and Drug Delivery

The most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix(ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photofabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.

Stabilizability analysis of sphere plants

Let P（s, δ） be a sphere plant family described by the transfer function set where the coefficients of the denominator and numerator polynomials are affine in a real uncertain parameter vector δ satisfying the Euclidean norm constraint ｜｜δ｜｜〈δ. The concept of stabilizability radius of P（s, δ） is introduced which is the norm bound δs for δ such that every member plant of P（s, δ） is stabilizable if and only if ｜｜δ｜｜〈δs. The stabilizability radius can be simply interpreted as the ＇largest sphere＇ around the nominal plant P（s,θ） such that P（s, δ） is stabilizable. The numerical method and the analytical method are presented to solve the stabilizability radius calculation problem of the sphere plants.

Ecological effects of Tongren City land transferring

The ecological effects of land transfer are mainly around the ecological effects of land itself. One is environmental and ecological effects of land, such as flood controlling, preventing soil erosion, preventing the collapse debris, water conservation and maintenance of biodiversity and conservation of wildlife. Second, it is crop residue use of land, including： treatment of organic waste, decomposing and eliminating contaminants, regulating microclimate and air purification, maintaining and revitalizing rural communities. Third, the geographical landscape effects of land, such as providing idyllic pastures and other entertainment services. In a conclusion, there is little exploration to the ecological effects of rural land. This paper attempts to analyze the environmental problems related to the land transferring in Tongren City.

Current and future editing reagent delivery systems for plant genome editing

Many genome editing tools have been developed and new ones are anticipated; some have been extensively applied in plant genetics, biotechnology and breeding, especially the CRISPR/Cas9 system. These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems. Finally, we will reflect on possible future directions.

Wnt signaling in the nervous system and in Alzheimer＇s disease

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological pro- cesses. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer＇s disease （AD）. We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to： （i） act as potent regulators of hippocampai synapses and impact in learning and memory; （ii） regulate adult neurogenesis; and finally （iii） control AD pathogenesis.

Magnetic drug delivery systems

There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems （DDSs） have great potential for clin- ical applications. Among these, magnetic drug delivery systems （MDDSs） based on magnetic nanoparticles （MNPs） are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite （y-Fe^03） or magnetite （Fe304） nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.