Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for th...Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for the first time a patient was given a retinal implant in order to treat dry agerelated macular degeneration. Retinal implants are suitable solutions for diseases that attack photoreceptors but spare most of the remaining retinal neurons. For eye diseases that result in loss of retinal output, implants that interface with more central structures in the visual system are needed. The standard site for central visual prostheses under development is the visual cortex. This perspective discusses the technical and socioeconomic challenges faced by visual prostheses.展开更多
Objective：To explore the expression of nuclear receptor corepressor （NCoR） in androgen independence prostate cancer （AIPC） and its clinical significance. Methods：The expression of NCoR and androgen receptor （AR...Objective：To explore the expression of nuclear receptor corepressor （NCoR） in androgen independence prostate cancer （AIPC） and its clinical significance. Methods：The expression of NCoR and androgen receptor （AR） in prostatie tissues, from 15 cases with AIPC, 20 cases with androgen dependence prostate cancer （ADPC） and 20 cases with benign prostatic hyperplasia （BPH）, was detected by immunohistoehemistry respectively. Results：The expression of NCoR was observed mainly in the nucleus and slightly in the nucleus. The positive cell percentage of NCoR in AIPC was significantly lower than that in ADPC and BPH （P〈0. 01）. The NCoR expression was significantly lower in low differentiation prostate cancer （Pca） than that in high differentiation Pca （P〈0. 05）. The rate of NCoR expression was significantly higher in low stage Pca than that in high stage Pca （P〈0. 05）. AR, expressing in the nucleus, was found to be negative in one case of AIPC, while was strongly expressed in other cases of AIPC, and all eases of ADPC and BPH. Conclusion： The transition to AIPC of Pea may be correlated with the decrease of NCoR protein.展开更多
基金the National Priorities Research Program (NPRP) (NPRP 5-457-2-181) from the Qatar National Research Fund (a member of Qatar Foundation)
文摘Visual prostheses are now entering the clinical marketplace. Such prostheses were originally targeted for patients suff ering from blindness through retinitis pigmentosa(RP). However, in late July of this year, for the first time a patient was given a retinal implant in order to treat dry agerelated macular degeneration. Retinal implants are suitable solutions for diseases that attack photoreceptors but spare most of the remaining retinal neurons. For eye diseases that result in loss of retinal output, implants that interface with more central structures in the visual system are needed. The standard site for central visual prostheses under development is the visual cortex. This perspective discusses the technical and socioeconomic challenges faced by visual prostheses.
文摘Objective：To explore the expression of nuclear receptor corepressor （NCoR） in androgen independence prostate cancer （AIPC） and its clinical significance. Methods：The expression of NCoR and androgen receptor （AR） in prostatie tissues, from 15 cases with AIPC, 20 cases with androgen dependence prostate cancer （ADPC） and 20 cases with benign prostatic hyperplasia （BPH）, was detected by immunohistoehemistry respectively. Results：The expression of NCoR was observed mainly in the nucleus and slightly in the nucleus. The positive cell percentage of NCoR in AIPC was significantly lower than that in ADPC and BPH （P〈0. 01）. The NCoR expression was significantly lower in low differentiation prostate cancer （Pca） than that in high differentiation Pca （P〈0. 05）. The rate of NCoR expression was significantly higher in low stage Pca than that in high stage Pca （P〈0. 05）. AR, expressing in the nucleus, was found to be negative in one case of AIPC, while was strongly expressed in other cases of AIPC, and all eases of ADPC and BPH. Conclusion： The transition to AIPC of Pea may be correlated with the decrease of NCoR protein.
