基于Modbus通讯在智能物料架中的应用

Modbus是一种串行通信协议,是Modicon公司(即施耐德电气Schneider Electric)于1979年为使用可编程逻辑控制器(PLC)通信而发表。Modbus已经成为工业领域通信协议的业界标准(De facto),并且现在是工业电子设备之间常用的连接方式。本文主要说明Modbus RTU通讯协议,西门子1200PLC如何通过Modbus RTU实现对智能物料架的智能化的显示与引导。

轻质颗粒物料防架桥进料器的设计

为了解决食品生产过程中进料器的物料架桥与挂壁问题,传统的料仓采用置于料仓内部的搅拌轴、螺带、弹簧杆,以及置于料仓出料口的水平和垂直往返运动防架桥装置等设计,但都未能改变料仓中存在斜面支撑的问题,这是物料产生架桥与挂壁的根本原因。该设计改进了长方体料仓防架桥装置,彻底改变传统料仓中存在倾斜面的结构,使物料在料仓中不易产生架桥。该装置在实际运用中具有加料方便、进料流畅、稳定均匀等特点。

基于Pro/E的龙门架物料提升机设计

提出了在Pro/E环境下进行龙门架物料提升机设计的方法,简单阐述了以设计为中心的虚拟装配设计思想及龙门架物料提升机的设计思路,详细叙述了基于Pro/E的龙门架物料提升机的设计过程。用实例表明了Pro/E三维软件在新产品开发中的优越性,如提高设计质量,缩短产品开发周期,降低生产成本等。

危岩体防治工程中物料提升架的设计和应用

本文讨论了三峡链子崖危岩体防治工程中的垂直运输设备，用碗扣式脚手架搭设的８２．６ｍ高物料提升井架，通过对单立杆承受荷载的计算，整体稳定性分析和荷载试验，证明该物料提升架达到设计要求，能很好地满足施工需要。

Topology optimization of microstructure and selective laser meltingfabrication for metallic biomaterial scaffolds

The precise design and fabrication of biomaterial scaffolds is necessary to provide a systematic study for bone tissue engineering. Biomaterial scaffolds should have sufficient stiffness and large porosity. These two goals generally contradict since larger porosity results in lower mechanical properties. To seek the microstructure of maximum stiffness with the constraint of volume fraction by topology optimization method, algorithms and programs were built to obtain 2D and 3D optimized microstructure and then they were transferred to CAD models of STL format. Ti scaffolds with 30% volume fraction were fabricated using a selective laser melting （SLM） technology. The architecture and pore shape in the metallic biomaterial scaffolds were relatively precise reproduced and the minimum mean pore size was 231μm. The accurate fabrication of intricate microstructure has verified that the SLM process is suitable for fabrication of metallic biomaterial scaffolds.

大型汽车部件自动化立体仓储的设计与实现

以大型汽车部件自动化立体仓储为研究对象,根据大型汽车部件的料架传送、解垛及堆垛三个重点生产环节,确定各个环节工作节拍。根据各个环节的工作节拍,设计了大型汽车部件自动化立体仓储的实施方案,取代了由叉车传送的传统仓储方式,降低了成本,保证了生产的安全,生产效率大幅提高。实际运行结果表明,该系统满足自动化立体仓储要求,故障率低,节约了物流成本,对精益化生产、优化生产线节拍,推动汽车行业迅速发展具有重要意义。

糊树脂成品料下料系统改造

糊树脂成品自动包装机下料系统由于物料流动性差、贮斗内物料架桥,造成下料不畅,影响包装速度。通过几次改进实现了下料顺畅,从而使包装机包装达产。

Tissue engineering for the repair of peripheral nerve injury

Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold material, the seed cells and various growth factors. Understanding the type of nerve injury, the construction of scaffold and the process of repair are necessary to solve peripheral nerve injury and promote its regeneration. This review describes the categories of peripheral nerve injury, fundamental research of peripheral nervous tissue engineering and clinical research on peripheral nerve scaffold material, and paves a way for related research and the use of conduits in clinical practice.

A LCA Based Biofuel Supply Chain Analysis Framework

This paper presents a life cycle assessment(LCA) based biofuel supply chain(SC) analysis framework which enables the study of economic, energy and environmental(3E) performances by using multi-objective optimization. The economic objective is measured by the total annual profit, the energy objective is measured by the average fossil energy(FE) inputs per MJ biofuel and the environmental objective is measured by greenhouse gas(GHG) emissions per MJ biofuel. A multi-objective linear fractional programming(MOLFP) model with multi-conversion pathways is formulated based on the framework and is solved by using the ε-constraint method. The MOLFP problem is turned into a mixed integer linear programming(MILP) problem by setting up the total annual profit as the optimization objective and the average FE inputs per MJ biofuel and GHG emissions per MJ biofuel as constraints. In the case study, this model is used to design an experimental biofuel supply chain in China. A set of the weekly Pareto optimal solutions is obtained. Each non-inferior solution indicates the optimal locations and the amount of biomass produced, locations and capacities of conversion factories, locations and amount of biofuel being supplied in final markets and the flow of mass through the supply chain network(SCN). As the model reveals trade-offs among 3E criteria, we think the framework can be a good support tool of decision for the design of biofuel SC.

Peroxymonosulfate activation by Mn_3O_4/metal-organic framework for degradation of refractory aqueous organic pollutant rhodamine B

An environmentally friendly Mn‐oxide‐supported metal‐organic framework(MOF),Mn3O4/ZIF‐8,was successfully prepared using a facile solvothermal method,with a formation mechanism proposed.The composite was characterized using X‐ray diffraction,scanning electron microscopy,transmission electron microscopy,X‐ray photoelectron microscopy,and Fourier‐transform infrared spectroscopy.After characterization,the MOF was used to activate peroxymonosulfate(PMS)for degradation of the refractory pollutant rhodamine B(RhB)in water.The composite prepared at a0.5:1mass ratio of Mn3O4to ZIF‐8possessed the highest catalytic activity with negligible Mn leaching.The maximum RhB degradation of approximately98%was achieved at0.4g/L0.5‐Mn/ZIF‐120,0.3g/L PMS,and10mg/L initial RhB concentration at a reaction temperature of23°C.The RhB degradation followed first‐order kinetics and was accelerated with increased0.5‐Mn/ZIF‐120and PMS dosages,decreased initial RhB concentration,and increased reaction temperature.Moreover,quenching tests indicated that?OH was the predominant radical involved in the RhB degradation;the?OH mainly originated from SO4??and,hence,PMS.Mn3O4/ZIF‐8also displayed good reusability for RhB degradation in the presence of PMS over five runs,with a RhB degradation efficiency of more than96%and Mn leaching of less than5%for each run.Based on these findings,a RhB degradation mechanism was proposed.

建设部推广项目

【正】 插卡型多功能脚手架 该脚手架具有装拆快捷,灵活多用,稳定性好,安全可靠等特点,可拼装成不同框架尺寸和施工荷载的单、双排脚手架,支撑架、支撑柱、平台架。

Three-dimensional printing of β-tricalcium phosphate/calcium silicate composite scaffolds for bone tissue engineering

Bioactive scaffolds with interconnected porous structures are essential for guiding cell growth and new bone formation. In this work, we successfully fabricated three-dimensional （3D） porous β-tricalcium phosphate （β-TCP）/calcium silicate （CS） composite scaffolds with different ratios by 3D printing technique and further investigated the physiochemical properties, in vitro apatite mineralization properties and degradability of porous β-TCP/CS scaffolds. Moreover, a series of in vitro cell experiments including the attachment, proliferation and osteogenic differentiation of mouse bone marrow stromal cells were conducted to testify their biological performances. The results showed that 3D printed β-TCP/CS scaffolds possessed of controllable internal porous structures and external shape. Furthermore, the introduction of CS decreased the shrinkage of scaffolds and improved the in vitro apatite formation activity and degradation rate. Meanwhile, compared with pure β- TCP scaffold, the β-TCP/CS composite scaffolds were more conducive to promote cell adhesion, spread and osteogenesis differentiation. However, when the content of CS was increased to 45%, the ions dissolution rate of the composite scaffolds was so high that leaded to the increase in pH value, which inhibited the proliferation of cells. Our results suggested that the introduction of appropriate CS into β-TCP bioceramic is an effective strategy to prepare bioactive 3D printed bioceramic scaffolds for hard tissue regeneration.

项目

插卡型多功能脚手架 它是一种工具式建筑施工用产品。它具有装拆快捷,灵活多用,稳定性好,安全可靠等特点,可拼装成不同框架尺寸和施工荷载的单、双排脚手架,支撑架、支撑柱、平台架、承重货架及物料提升架等各种支撑体系。其关键技术是由专用检测工具检测达标的模具,控制精铸而成的整体式插座,与插头形成环形锥度配合。在装配工艺线上装配形成脚手架。该脚手架力学性能优越,而且承重愈大其结点愈牢固,稳定性愈好。

Research on the Influence of HPMC Release the Bupropion Hydrochloride Sustained Release Tablets

Objective Study of bupropion hydrochloride gel matrix sustained release tablet and the preparation method, test the skeleton material of hydroxypropyl methyl cellulose influencing drug release for evaluation, explore the preparation of sustained release tablets of optimization method. Method With hydroxypropyl methyl cellulose as skeleton material, according to the different prescription preparation of bupmpion hydrochloride sustained release tablets. Different HPMC viscosity, Consumption, particle size, compression pressure and slurry rotational speed and other factors, analysis the influence on drug release rate.Through the release of test evaluation of sustained release effect, and the preliminary study on the drug release characteristic. With hydroxypropyl methyl cellulose （ HPMC ） as skeleton material, with citric acid citrate as a porogenic agent, direct powder tabletting method of bupropion hydrochloride sustained release tablets; by using single factor and orthogonal experiment method to investigate HPMC different viscosity, different Consumption, different particle size, different compression pressure, different pulp rotational speed and other factors on the release of delivery rate. Result Select HPMC-K100M for bupropion hydrochloride sustained release tablets of the skeleton materials; reinforcing materials of high viscosity HPMC K100M and main drug quality ratio of 1： 1; HPMC particle diameter of 125p m, make use of these conditions to preparation of bupropion hydrochloride sustained release tablets for optimal prescription conditions. Conclusion bupropion hydroehloride sustained release tablets on the drug release rate is mainly affected by HPMC viscosity and dosage effect. Along with the tablet of HPMC viscosity increased, the drug is released slowly. HPMC viscosity, dosage on the drug release rate has significant influence.

Study of biological safety of scaffold material with heterologous deproteinized bone

To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications. Methods ： Deproteinized bone （ 10 mm） and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test. Results ： No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramusclar implantation and cytotoxity were observed. Conclusions： The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.

Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds

Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies.In the present study,novel biomimetic composite scaffolds,with similar properties to natural bone,were prepared,blended and cross-linked with bioactive glass,type I collagen and phosphatidylserine.When exposed to cell culture solution in the absence of a cellular source,the composite scaffolds form crystals with octahedral structure.These crystals are similar to the products derived from MC3T3-E1 cell mineralization within the composite scaffolds,with respect to both composition and morphology.Furthermore,crystals with octahedral structure were observed to develop into plate-like hydroxyapatite.The bio-mineralization behavior of the composite scaffolds is likely influenced by inorganic components.Finally,a rabbit tibia defect model shows that the highly bioactive properties of the investigated composites result in excellent bone repair.

Biomaterial Scaffolds with Biomimetic Fluidic Channels for Hepatocyte Culture

Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex microchannel network inside three-dimensional （3D） scaffolds for efficient mass transportation. Here we presented a biomimetic strategy to generate a mi- crochannel network within porous biomaterial scaffolds by mimicking the vascular tree of rat liver. The typical parameters of the blood vessels were incorporated into the biomimetic design of the microchannel network such as branching angle and diameter. Silk fibroin-gelatin scaffolds with biomimetic vascular tree were fabricated by combining micromolding, freeze drying and 3D rolling techniques. The relationship between the micro-channeled design and flow pattern was revealed by a flow experiment, which indicated that the scaffolds with biomimetic vascular tree exhibited unique capability in improving mass transportation inside the 3D scaffold. The 3D scaffolds, preseeded with primary hepatocytes, were dynamically cultured in a bioreactor system. The results confirmed that the pre-designed biomimetic microchannel network facilitated the generation and expansion of hepatocytes.

Luminescent metal-organic frameworks for nitro explosives detection

Metal-organic frameworks （MOFs） have been emerging as important multifunctional hybrid materials, not only due to the diversify framework architectures, but also contribute to the rich interactions among metals, ligands and guests. Nitro explosives have important influences tbr environmental protection and national homeland security, in this review, a brief description of luminescent MOFs is presented, accompanied by a short comment on the four types of metal-based luminescent MOFs as sensing materials for nitro explosives detection. Then the trends and challenges of luminescent MOFs as sensing materials ibr nitro explosives are also prospected.

Biodegradable magnesium implants:a potential scaffold for bone tumor patients

Relapse and metastasis of tumor may occur for osteosarcoma(OS)patients after clinical resection.Conventional metallic scaffolds provide sufficient mechanical support to the defected bone but fail to eradicate recurring tumors.Here we report that biodegradable magnesium(Mg)wirebased implant can inhibit OS growth.In brief,the Mg wires release Mg ions to activate the transport of zinc finger protein Snail1 from cytoplasm to cell nucleus,which induces apoptosis and inhibits proliferation of OS cells through a parallel antitumor signaling pathway of miRNA-181d-5p/TIMP3 and miRNA-181c-5p/NLK downstream.Simultaneously,the hydrogen gas evolution from Mg wires eliminates intracellular excessive reactive oxygen species,by which the growth of bone tumor cells is suppressed.The subcutaneous tumor-bearing experiment of OS cells in nude mice further confirms that Mg wires can effectively inhibit the growth of tumors and prolong the survival of tumor-bearing mice.In addition,Mg wires have no toxicity to normal cells and tissues.These results suggest that Mg implant is a potential anti-tumor scaffold for OS patients.

Microscale methods to assemble mammalian cells into tissue-like structures

Different cell types make up tissues and organs hierarchically and communicate within a complex, three-dimensional (3D) en- vironment. The in vitro recapitulation of tissue-like structures is meaningful, not only for fundamental cell biology research, but also for tissue engineering (TE). Currently, TE research adopts either the top-down or bottom-up approach. The top-down approach involves defining the macroscopic tissue features using biomaterial scaffolds and seeding cells into these scaffolds. Conversely, the bottom-up approach aims at crafting small tissue building blocks with precision-engineered structural and functional microscale features, using physical and/or chemical approaches. The bottom-up strategy takes advantage of the repeating structural and functional units that facilitate cell-cell interactions and cultures multiple cells together as a functional unit of tissue. In this review, we focus on currently available microscale methods that can control mammalian cells to assemble into 3D tissue-like structures.