This article describes the effective channel length degradation under hot carrier stressing. The extraction is based on the IDs-Vcs characteristics by maximum transconductance （maximum slope of IDs ＆ VGS） in the li...This article describes the effective channel length degradation under hot carrier stressing. The extraction is based on the IDs-Vcs characteristics by maximum transconductance （maximum slope of IDs ＆ VGS） in the linear region. The transconductance characteristics are determine for the several devices of difference drawn channel length. The effective channel length of submicron LDD （Lightly Doped Drain） NMOSFETs （Metal Oxide Semiconductor Field Effect Transistor） under hot carrier stressing was measured at the stress time varying from zero to 10,000 seconds. It is shown that the effective channel length was increased with time. This is caused by charges trapping in the oxide during stress. The increased of effective channel length （△Leff） is seem to be increased sharply as the gate channel length is decrease.展开更多
Microparticles have a demonstrated value for drug delivery systems. The attempts to develop this tech- nology focus on the generation of featured microparticles for improving the function of the systems. Here, we pres...Microparticles have a demonstrated value for drug delivery systems. The attempts to develop this tech- nology focus on the generation of featured microparticles for improving the function of the systems. Here, we present a new type of microparticles with gelatin methacrylate （GelMa） cores and poly（L-lactide-co-glycolide） （PLGA） shells for syn- ergistic and sustained drug delivery applications. The mi- croparticles were fabricated by using GelMa aqueous solu- tion and PLGA oil solution as the raw materials of the mi- croflnidic double emulsion templates, in which hydrophilic and hydrophobic actives, such as doxorubicin hydrochloride （DOX, hydrophilic） and camptothecine （CPT, hydrophobic）, could be loaded respectively. As the inner cores were poly- merized in the microfluidics when the double emulsions were formed, the hydrophilic actives could be trapped in the cores with high efficiency, and the rupture or fusion of the cores could be avoided during the solidification of the micropar- ticle shells with other actives. The size and component of the microparticles can be easily and precisely adjusted by ma- nipulating the flow solutions during the microfluidic emulsi- fication. Because of the solid structure of the resultant mi- croparticles, the encapsulated actives were released from the delivery systems only with the degradation of the biopolymer layers, and thus the burst release of the actives was avoided. These features of the microparticles make them ideal for drug delivery applications.展开更多
Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional ...Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional microparticles by using convenient methods with innovative but accessible materials.Inspired by the process of boiling eggs in everyday life,which causes the solidification of egg proteins,we present a new microfluidic‘‘cooking"approach for the generation of egg-derived microcarriers for cell culture and drug delivery.As the egg emulsion droplets are formed with exquisite precision during the microfluidic emulsification,the resultant egg microcarriers present highly monodisperse and uniform morphologies at the size range of hundred microns to one millimeter.Benefiting from the excellent biocompatibility of the egg protein components,the obtained microcarriers showed good performances of cell adherence and growth.In addition,after a freezing treatment,the egg microcarriers were shown to have interconnected porous structures throughout their whole sphere,could absorb and load different kinds of drugs or other active molecules,and work as microcarrier-based delivery systems.These features point to the potential value of the microfluidic egg microcarriers in biomedicine.展开更多
文摘This article describes the effective channel length degradation under hot carrier stressing. The extraction is based on the IDs-Vcs characteristics by maximum transconductance （maximum slope of IDs ＆ VGS） in the linear region. The transconductance characteristics are determine for the several devices of difference drawn channel length. The effective channel length of submicron LDD （Lightly Doped Drain） NMOSFETs （Metal Oxide Semiconductor Field Effect Transistor） under hot carrier stressing was measured at the stress time varying from zero to 10,000 seconds. It is shown that the effective channel length was increased with time. This is caused by charges trapping in the oxide during stress. The increased of effective channel length （△Leff） is seem to be increased sharply as the gate channel length is decrease.
基金supported by the National Natural Science Foundation of China (21473029 and 51522302) the NSAF Foundation of China (U1530260)+4 种基金the National Science Foundation of Jiangsu (BK20140028) the Program for New Century Excellent Talents in Universitythe Scientific Research Foundation of Southeast UniversityFoundation of Jiangsu Cancer Hospital (ZN201609)Beijing Medical Award Foundation (YJHYXKYJJ-433)
文摘Microparticles have a demonstrated value for drug delivery systems. The attempts to develop this tech- nology focus on the generation of featured microparticles for improving the function of the systems. Here, we present a new type of microparticles with gelatin methacrylate （GelMa） cores and poly（L-lactide-co-glycolide） （PLGA） shells for syn- ergistic and sustained drug delivery applications. The mi- croparticles were fabricated by using GelMa aqueous solu- tion and PLGA oil solution as the raw materials of the mi- croflnidic double emulsion templates, in which hydrophilic and hydrophobic actives, such as doxorubicin hydrochloride （DOX, hydrophilic） and camptothecine （CPT, hydrophobic）, could be loaded respectively. As the inner cores were poly- merized in the microfluidics when the double emulsions were formed, the hydrophilic actives could be trapped in the cores with high efficiency, and the rupture or fusion of the cores could be avoided during the solidification of the micropar- ticle shells with other actives. The size and component of the microparticles can be easily and precisely adjusted by ma- nipulating the flow solutions during the microfluidic emulsi- fication. Because of the solid structure of the resultant mi- croparticles, the encapsulated actives were released from the delivery systems only with the degradation of the biopolymer layers, and thus the burst release of the actives was avoided. These features of the microparticles make them ideal for drug delivery applications.
基金supported by the National Natural Science Foundation of China (21473029, 51522302)the NSAF Foundation of China (U1530260)+2 种基金the Natural Science Foundation of Jiangsu Province (BK20140028)the Program for New Century Excellent Talents in Universitythe Scientific Research Foundation of Southeast University
文摘Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional microparticles by using convenient methods with innovative but accessible materials.Inspired by the process of boiling eggs in everyday life,which causes the solidification of egg proteins,we present a new microfluidic‘‘cooking"approach for the generation of egg-derived microcarriers for cell culture and drug delivery.As the egg emulsion droplets are formed with exquisite precision during the microfluidic emulsification,the resultant egg microcarriers present highly monodisperse and uniform morphologies at the size range of hundred microns to one millimeter.Benefiting from the excellent biocompatibility of the egg protein components,the obtained microcarriers showed good performances of cell adherence and growth.In addition,after a freezing treatment,the egg microcarriers were shown to have interconnected porous structures throughout their whole sphere,could absorb and load different kinds of drugs or other active molecules,and work as microcarrier-based delivery systems.These features point to the potential value of the microfluidic egg microcarriers in biomedicine.
