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物系约束下的加速度关联特征解析 被引量:1
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作者 王国华 邵壮 《理科考试研究》 2021年第19期45-46,共2页
物系约束下的加速度关联问题是竞赛或北清校考的常见问题.对于加速度在法线方向是否具有相同的分量,很多学生容易因思维定势做出错误判断,得出错误结论.现针对此类问题,本文尝试通过一道具体连接体问题的求解,从不同角度分析得出加速度... 物系约束下的加速度关联问题是竞赛或北清校考的常见问题.对于加速度在法线方向是否具有相同的分量,很多学生容易因思维定势做出错误判断,得出错误结论.现针对此类问题,本文尝试通过一道具体连接体问题的求解,从不同角度分析得出加速度相关问题的解决方案,以期帮助学生进一步阐述物系约束下的加速度关联特征. 展开更多
关键词 物系约束 速度关联 加速度关联 相对运动
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On the necessity of an integrative approach to understand protein structural dynamics
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作者 Qing-fen YANG Chun TANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2019年第6期496-502,共7页
Proteins are dynamic,fluctuating between multiple conformational states.Protein dynamics,spanning orders of magnitude in time and space,allow proteins to perform specific functions.Moreover,under certain conditions,pr... Proteins are dynamic,fluctuating between multiple conformational states.Protein dynamics,spanning orders of magnitude in time and space,allow proteins to perform specific functions.Moreover,under certain conditions,proteins can morph into a different set of conformations.Thus,a complete understanding of protein structural dynamics can provide mechanistic insights into protein function.Here,we review the latest developments in methods used to determine protein ensemble structures and to characterize protein dynamics.Techniques including X-ray crystallography,cryogenic electron microscopy,and small angle scattering can provide structural information on specific conformational states or on the averaged shape of the protein,whereas techniques including nuclear magnetic resonance,fluorescence resonance energy transfer(FRET),and chemical cross-linking coupled with mass spectrometry provide information on the fluctuation of the distances between protein domains,residues,and atoms for the multiple conformational states of the protein.In particular,FRET measurements at the single-molecule level allow rapid resolution of protein conformational states,where information is otherwise obscured in bulk measurements.Taken together,the different techniques complement each other and their integrated use can offer a clear picture of protein structure and dynamics. 展开更多
关键词 Conformational dynamics Integrative structural biology Distance restraint Ensemble averaging Nuclear magnetic resonance(NMR)
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