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纳米银/聚氨酯覆膜新型抗菌气管导管在大鼠体内的抗菌性实验研究
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作者 黄晓霞 徐成 《中国当代医药》 2017年第6期4-6,共3页
目的探讨纳米银/聚氨酯覆膜新型抗菌气管导管在大鼠体内的抗菌能力。方法选取2016年1月深圳北京大学香港科技大学医学中心提供的48只SPF级SD雄性大鼠为研究对象。随机选取24只行气管内插管手术并在体内留置纳米银/聚氨酯覆膜新型抗菌气... 目的探讨纳米银/聚氨酯覆膜新型抗菌气管导管在大鼠体内的抗菌能力。方法选取2016年1月深圳北京大学香港科技大学医学中心提供的48只SPF级SD雄性大鼠为研究对象。随机选取24只行气管内插管手术并在体内留置纳米银/聚氨酯覆膜新型抗菌气管导管的健康大鼠作为实验组,同时随机选取同期行气管内插管手术并在体内留置普通气管导管的24只健康大鼠作为对照组。分别于术后12、24、48、72 h用平板菌落计数法检测两组大鼠的肺泡灌洗液的菌落数,并用显微镜观察两组大鼠内置导管所形成的生物膜厚度。结果术后12 h,两组大鼠肺泡灌洗液的菌落数比较,差异无统计学意义(P>0.05)。术后24、48 h及72 h实验组大鼠肺泡灌洗液的菌落数显著少于对照组(P<0.05)。术后12、24 h,两组大鼠内置导管所形成的生物膜厚度比较,差异无统计学意义(P>0.05)。实验组大鼠术后48、72 h内置导管所形成的生物膜厚度明显低于对照组(P<0.05)。结论纳米银/聚氨酯覆膜新型抗菌气管导管相较于普通导管有更强的抗菌及抗生物膜增生的性能。 展开更多
关键词 纳米银/聚氨酯覆新型抗菌气管导管 肺泡灌洗液 菌落数 物膜厚度
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Evaluation of corneal parameter changes under different accommodative stimuli with Scheimpflug imaging-based tomography
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作者 Farid J Bedrán-García David P Piñero 《国际眼科杂志》 CAS 2024年第9期1357-1366,共10页
AIM:To evaluate the reliability of measurements of corneal changes with accommodation in healthy eyes using a Scheimpflug imaging-based system and how these measurements distribute in the normal population.METHODS:Pro... AIM:To evaluate the reliability of measurements of corneal changes with accommodation in healthy eyes using a Scheimpflug imaging-based system and how these measurements distribute in the normal population.METHODS:Prospective,non-randomized,comparative study including 27 healthy subjects(54 eyes),including emmetropia(13 eyes),myopia(17 eyes),hyperopia(4 eyes)and astigmatism(20 eyes)groups.In all cases,a complete eye examination was performed,including the analysis of corneal changes with different accommodative stimuli(+2.00,0.00 and-3.00 D)using the Pentacam AXL system.The investigation was structured in 2 phases:repeatability analysis and characterization of accommodation-related corneal changes in healthy populations.RESULTS:In the repeatability analysis,the index of height asymmetry(IHA)showed the greatest variability with the three accommodative stimuli,being the results for the rest of parameters acceptable.The group of emmetropes showed significant differences with accommodative changes in the position of maximum keratometry(Kmax;P<0.05),whereas in the astigmatism group,significant changes were not only observed in the position of Kmax,but also in minimum corneal thickness(MCT),corneal spherical aberration,and total and low order aberration root mean square(all P<0.05).Likewise,a significant difference was found in the displacement of the X position of Kmax with+2.00 D and-3.00 D in the myopia group(P=0.033)as well as in changes with+2.00 D and-3.00 D in the magnitude of the position vector of Kmax in the emmetropia group(P<0.05).No significant changes were found between accommodative stimuli in the displacement of coordinates of MCT(P≥0.109).CONCLUSION:The position of Kmax and MCT in healthy corneas can change significantly when presenting different accommodative stimuli using the accommodation mode of the Pentacam system,with different trends in these accommodation-related corneal changes between refractive errors.Likewise,the consistency of the measurements obtained with Scheimpflug has been confirmed. 展开更多
关键词 corneal biomechanics KERATOMETRY corneal thickness PACHYMETRY corneal aberrations PENTACAM ACCOMMODATION
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