Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in |apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arre...Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in |apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arrests. Abuse of a stimulant called Philopon was widespread after the Second World War in ]apan, but the situation was dramatically improved after 1954 because the Japanese government enacted the Stimulant Control Act and restructured the police system and Japanese society recovered from post-war unrest. The situation of drug abuse in Japan has become less serious compared to the past and to the situation in many other countries, because we are taking comprehensive and nationwide measures, including proactive disclosure of the situation, control, drug abuse prevention class, and introduction of partial suspension of sentence. On the other hand, as in many countries, the rapid spread of new psychoactive substances (NPS) in recent years became a serious social issue. The situation of NPS has been rapidly improving due to comprehensive and government-wide measures, but the means of acquisition is quickly shifting to the Internet. It is necessary to strengthen cyber patrol.展开更多
Fatty acids(FAs) in sediment collected from three different stations in the Yellow Sea and the East China Sea were analyzed for their distributions and to determine evidence of harmful algal blooms in the sediment cor...Fatty acids(FAs) in sediment collected from three different stations in the Yellow Sea and the East China Sea were analyzed for their distributions and to determine evidence of harmful algal blooms in the sediment core.Less diverse FAs were found in the Yellow Sea(YS) station,whereas in the two stations of the East China Sea(ECS) the FAs were more diverse.Concentrations of some FA species in the two ECS stations displayed an occasional surge in their vertical profile.The highest concentration of FAs was found in the surface layer of station QT3(43.28 μg g^(-1)).Monounsaturated FAs were more susceptible to degradation compared to their saturated counterparts,and changes of 16:0,18:2 and 20:5 accounted for the most variability in total concentrations of FAs as those species made up most of the quantified FAs.The origins of the major fraction of FAs were attributed to autotrophic sources,and bacterial FAs accounted for only a small fraction of the total FAs in the region.Nutrient availability was a possible regulating factor controlling bacteria abundances in marine sediments in the ECS and the YS.A principal component analysis(PCA) was applied to analyze the FA dataset and to reveal the principal environmental factors that control the composition of FAs in the sediments.PC2,which explains 15% of the variance,was estimated to reflect the diagenetic effects on the FA compositional changes in sediments influenced by bacterial degradation.展开更多
The present study achieves the biochemistry partial characterization of the chitinolytic extract produced by an endophytic Streptomyces sp. strain (A8). This extract was also tested against Anthonomus grandis, the c...The present study achieves the biochemistry partial characterization of the chitinolytic extract produced by an endophytic Streptomyces sp. strain (A8). This extract was also tested against Anthonomus grandis, the cotton boll weevil aiming its control. The chitinase crude extract from the A8 strain was cultured for five days in a minimum liquid media supplemented with chitin. The extract was partially characterized by standard methods. The chitinolytic extract had an optimum temperature of 66 "C and an optimum pH between 4 to 9 (around 80% of relative activity). We also characterized the temperature and pH stability and measured the effects of enzyme inhibitors. The filtered chitinolytic extract was added to an artificial boll weevil diet. Boll weevil development from the egg stage to the adult stage was prolonged, and the percentage of adults that emerged was approximately 66% less than on control diet. This study showed that the.larval development of A. grandis was inhibited by the presence of characterized chitinolytic extract in artificial diet. This work provides an experimental basis for using the chitinase from an endophytic bacterium Streptomyces sp. as a biocontrol alternativeto controlling the plant pest A. grandis.展开更多
Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more tha...Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more than 149 compounds in Chuanxiong Rhizoma have been isolated and identified,and some of them have been reported to possess promising biological properties on cardiovascular and central nervous system disorders besides their anti-cancer and antioxidant effects.Modulation of inflammatory mediators and apoptotic factors are believed to contribute to its bioactivities.Analytical methods,such as HPLC,GC and UPLC,are employed for qualitative evaluation of Chuanxiong Rhizoma.In this work,harvest period,growing habitat,processing method and storage,which can affect the quality of Chuanxiong Rhizoma,were also discussed.Comprehensive quality control methods should be developed to ensure the safety,quality and efficacy use of Chuanxiong Rhizoma.Herein,we collected and analyzed the literature of Chuanxiong Rhizoma published on CNKI,ScienceDirect,Springer link,Wiley and PubMed in past two decades,and up-to-date information of Chuanxiong Rhizoma was provided in this paper.We suggested ligustilide,butylidenephthalide and total senkyunolides as the chemical markers to evaluate the quality of Chuanxiong Rhizoma.Additionally,the influences of soil conditions and processing methods on Chuanxiong Rhizoma as future research perspectives should also be further assessed.展开更多
文摘Drug abuse is a common problem that all countries in the world face. The most distinguishing characteristic of drug abuse in |apart is that use of stimulants, mostly methamphetamine, accounts for over 80% of the arrests. Abuse of a stimulant called Philopon was widespread after the Second World War in ]apan, but the situation was dramatically improved after 1954 because the Japanese government enacted the Stimulant Control Act and restructured the police system and Japanese society recovered from post-war unrest. The situation of drug abuse in Japan has become less serious compared to the past and to the situation in many other countries, because we are taking comprehensive and nationwide measures, including proactive disclosure of the situation, control, drug abuse prevention class, and introduction of partial suspension of sentence. On the other hand, as in many countries, the rapid spread of new psychoactive substances (NPS) in recent years became a serious social issue. The situation of NPS has been rapidly improving due to comprehensive and government-wide measures, but the means of acquisition is quickly shifting to the Internet. It is necessary to strengthen cyber patrol.
基金supported by the National Key Research and Development Program of China(No.2016YFA0601302)the National Natural Science Foundation of China(No.41676067)+2 种基金the Fundamental Research Funds for the Central Universities(No.201762030)the National Natural Science Foundation for Creative Groups(No.41521064)the‘111’Program of Marine Chemistry(No.B13030)
文摘Fatty acids(FAs) in sediment collected from three different stations in the Yellow Sea and the East China Sea were analyzed for their distributions and to determine evidence of harmful algal blooms in the sediment core.Less diverse FAs were found in the Yellow Sea(YS) station,whereas in the two stations of the East China Sea(ECS) the FAs were more diverse.Concentrations of some FA species in the two ECS stations displayed an occasional surge in their vertical profile.The highest concentration of FAs was found in the surface layer of station QT3(43.28 μg g^(-1)).Monounsaturated FAs were more susceptible to degradation compared to their saturated counterparts,and changes of 16:0,18:2 and 20:5 accounted for the most variability in total concentrations of FAs as those species made up most of the quantified FAs.The origins of the major fraction of FAs were attributed to autotrophic sources,and bacterial FAs accounted for only a small fraction of the total FAs in the region.Nutrient availability was a possible regulating factor controlling bacteria abundances in marine sediments in the ECS and the YS.A principal component analysis(PCA) was applied to analyze the FA dataset and to reveal the principal environmental factors that control the composition of FAs in the sediments.PC2,which explains 15% of the variance,was estimated to reflect the diagenetic effects on the FA compositional changes in sediments influenced by bacterial degradation.
文摘The present study achieves the biochemistry partial characterization of the chitinolytic extract produced by an endophytic Streptomyces sp. strain (A8). This extract was also tested against Anthonomus grandis, the cotton boll weevil aiming its control. The chitinase crude extract from the A8 strain was cultured for five days in a minimum liquid media supplemented with chitin. The extract was partially characterized by standard methods. The chitinolytic extract had an optimum temperature of 66 "C and an optimum pH between 4 to 9 (around 80% of relative activity). We also characterized the temperature and pH stability and measured the effects of enzyme inhibitors. The filtered chitinolytic extract was added to an artificial boll weevil diet. Boll weevil development from the egg stage to the adult stage was prolonged, and the percentage of adults that emerged was approximately 66% less than on control diet. This study showed that the.larval development of A. grandis was inhibited by the presence of characterized chitinolytic extract in artificial diet. This work provides an experimental basis for using the chitinase from an endophytic bacterium Streptomyces sp. as a biocontrol alternativeto controlling the plant pest A. grandis.
基金The 12thinnovation activity plan-of undergraduates in the Shanghai University of Traditional Chinese Medicine(Grant No.2019SHUTCM060)the Natural Science Foundation of Shanghai(Grant No.19ZR1457700)+1 种基金2020 New Agricultural Science Research and Reform Practice Project of the Ministry of Education2020 Key Undergraduate Education Reform Project of Shanghai Colleges。
文摘Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more than 149 compounds in Chuanxiong Rhizoma have been isolated and identified,and some of them have been reported to possess promising biological properties on cardiovascular and central nervous system disorders besides their anti-cancer and antioxidant effects.Modulation of inflammatory mediators and apoptotic factors are believed to contribute to its bioactivities.Analytical methods,such as HPLC,GC and UPLC,are employed for qualitative evaluation of Chuanxiong Rhizoma.In this work,harvest period,growing habitat,processing method and storage,which can affect the quality of Chuanxiong Rhizoma,were also discussed.Comprehensive quality control methods should be developed to ensure the safety,quality and efficacy use of Chuanxiong Rhizoma.Herein,we collected and analyzed the literature of Chuanxiong Rhizoma published on CNKI,ScienceDirect,Springer link,Wiley and PubMed in past two decades,and up-to-date information of Chuanxiong Rhizoma was provided in this paper.We suggested ligustilide,butylidenephthalide and total senkyunolides as the chemical markers to evaluate the quality of Chuanxiong Rhizoma.Additionally,the influences of soil conditions and processing methods on Chuanxiong Rhizoma as future research perspectives should also be further assessed.