To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathichirsutism (IH). Design: Prospective randomized clinical study. Setting: Social Security Agency, Aegean Obstetric...To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathichirsutism (IH). Design: Prospective randomized clinical study. Setting: Social Security Agency, Aegean Obstetrics and Gynecology Teaching Hospital, Department of Reproductive Endocrinology and Infertility, a tertiary referral center. Patient( s): Eighty women with IH who had been admitted to our center. Intervention(s): Patients were randomly and equally assigned to receive flutamide (250 mg/d for the first 10 days of the cycle) and spironolactone plus Diane 35 (spironolactone 100 mg/d; Diane 35 is a combination tablet of 2 mg cyproterone acetate and 35 μ g ethinylestradiol/d) for 9 months. Main Outcome Measure(s): Modified Ferriman-Gallwey (F-G) score and hormonal profile before treatment and at the end of treatment. Result(s): In spite of the fact that there were no statistically significant differences in modified F-G scores in between the two groups, a significant decrease in modified F-G scores was observed in the flutamide (from 19.93 ± 4.31 to 15.58 ± 4.28)-and spironolactone plus Diane 35 (from 18.77 ± 3.76 to 14.54 ± 3.29) groups. There were also no differences between the two groups with respect to hormonal profiles including serum FSH, LH, free T, 17- OH-progesterone, and DHEAS levels. No major side effect, including liver toxicity, was observed in either group. Conclusion(s): Our data suggest that both therapies have similar effectiveness in the treatment of IH.展开更多
In a prospective randomized study 38 women with idiopathic hirsutism or polycystic ovary syndrome (PCOS) received 2.5 mg of finasteride every day or every 3 days. Intermittent lowdose administration of finasteridewas ...In a prospective randomized study 38 women with idiopathic hirsutism or polycystic ovary syndrome (PCOS) received 2.5 mg of finasteride every day or every 3 days. Intermittent lowdose administration of finasteridewas as effective as continuous administration in reducing hirsutism score and was accompanied by a lower incidence of side effects.展开更多
文摘To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathichirsutism (IH). Design: Prospective randomized clinical study. Setting: Social Security Agency, Aegean Obstetrics and Gynecology Teaching Hospital, Department of Reproductive Endocrinology and Infertility, a tertiary referral center. Patient( s): Eighty women with IH who had been admitted to our center. Intervention(s): Patients were randomly and equally assigned to receive flutamide (250 mg/d for the first 10 days of the cycle) and spironolactone plus Diane 35 (spironolactone 100 mg/d; Diane 35 is a combination tablet of 2 mg cyproterone acetate and 35 μ g ethinylestradiol/d) for 9 months. Main Outcome Measure(s): Modified Ferriman-Gallwey (F-G) score and hormonal profile before treatment and at the end of treatment. Result(s): In spite of the fact that there were no statistically significant differences in modified F-G scores in between the two groups, a significant decrease in modified F-G scores was observed in the flutamide (from 19.93 ± 4.31 to 15.58 ± 4.28)-and spironolactone plus Diane 35 (from 18.77 ± 3.76 to 14.54 ± 3.29) groups. There were also no differences between the two groups with respect to hormonal profiles including serum FSH, LH, free T, 17- OH-progesterone, and DHEAS levels. No major side effect, including liver toxicity, was observed in either group. Conclusion(s): Our data suggest that both therapies have similar effectiveness in the treatment of IH.
文摘In a prospective randomized study 38 women with idiopathic hirsutism or polycystic ovary syndrome (PCOS) received 2.5 mg of finasteride every day or every 3 days. Intermittent lowdose administration of finasteridewas as effective as continuous administration in reducing hirsutism score and was accompanied by a lower incidence of side effects.
