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小鼠皮肤移植特异耐受性的获得 被引量:4
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作者 王重庆 李启靖 +2 位作者 关迎辉 彭刚 郭亚迁 《北京大学学报(自然科学版)》 CAS CSCD 北大核心 1998年第4期481-487,共7页
通过2个不同品系小鼠间进行皮肤移植,研究免疫系统产生特异耐受的机制。要获得对异体抗原的特异性耐受,必须包括对外周淋巴器官中免疫效应细胞的特异杀伤,并同时诱导中枢免疫器官将其作为“自我”物质进行识别,导致系列克隆流产。... 通过2个不同品系小鼠间进行皮肤移植,研究免疫系统产生特异耐受的机制。要获得对异体抗原的特异性耐受,必须包括对外周淋巴器官中免疫效应细胞的特异杀伤,并同时诱导中枢免疫器官将其作为“自我”物质进行识别,导致系列克隆流产。以BALB/C鼠为受体,以C57BL/6(简称C57)鼠为供体,用包裹蓖麻毒素蛋白(ricin)的供体淋巴细胞作为“导弹毒剂”,对受体产生的排异供体移植抗原的T,B淋巴细胞进行定向杀伤,并事先用供体淋巴细胞对受体进行胸腺内注射,以使得识别移植抗原的T淋巴细胞的克隆流产。实验组移植皮片平均存活超过60d(天)(对照组为5d),t检验证明差异极其显著。单向混合淋巴细胞培养的MTT比色分析结果为导向毒细胞的定向杀伤功能和供体淋巴细胞胸腺注射的T细胞克隆衰减功能提供了细胞学证据。 展开更多
关键词 皮肤移植 异体移植 特异耐受性
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食物不耐受特异性IgG抗体与肠易激综合征关系的临床研究 被引量:9
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作者 陈兰 吕小平 +3 位作者 詹灵凌 罗虹 梁远 唐国都 《广西医学》 CAS 2015年第2期160-162,共3页
目的探讨食物不耐受特异性Ig G抗体与肠易激综合征(IBS)的关系。方法对128例IBS患者和80例健康体检者,应用酶联免疫吸附法半定量检测血清中14种食物不耐受特异性lg G抗体水平并分为0、+1、+2和+3级;根据检测结果剔除相应食物治疗8周,采... 目的探讨食物不耐受特异性Ig G抗体与肠易激综合征(IBS)的关系。方法对128例IBS患者和80例健康体检者,应用酶联免疫吸附法半定量检测血清中14种食物不耐受特异性lg G抗体水平并分为0、+1、+2和+3级;根据检测结果剔除相应食物治疗8周,采用调查表评分系统对IBS患者的症状进行评分以评价疗效。结果 128例IBS患者中,至少有1种食物不耐受特异性Ig G抗体阳性112例,阳性率为87.5%,明显高于对照组的9.3%(P<0.05)。IBS患者食物不耐受特异性Ig G阳性率以蟹(84.4%)和虾(75.0%)较高。128例IBS患者中Ig G抗体阳性+2以上的患者82例,经剔除相应食物治疗8周后,临床症状明显改善56例(68.3%),症状有所改善16例(19.5%),无效10例(12.2%),总有效率为87.8%(72/82)。结论根据IBS患者血清中食物不耐受特异性Ig G水平,剔除相应食物,能有效地改善IBS的临床症状。 展开更多
关键词 肠易激综合征 食物不耐受特异IgG 饮食治疗 非变应食物过敏症
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Intrathymic inoculation of donor liver specific antigen alleviates rejection of liver allotransplantation 被引量:1
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作者 贾长库 郑树森 章爱斌 《Journal of Zhejiang University Science》 CSCD 2003年第4期485-490,共6页
Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I:syngeneic control (Wistar to Wistar); Group II:acute rejection (SD to Wistar ); Group III: Thym... Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I:syngeneic control (Wistar to Wistar); Group II:acute rejection (SD to Wistar ); Group III: Thymic inoculation of SD rat LSA day 7 before transplantation. The observation of common situation and survival time, rejection grades, NF κB activity of splenocytes and IL 2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients of group II lost body weight progressively. All dead within day 9 to day 13 posttransplantation; median survival time was 10.7 ±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group II( P <0.05). NF κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF κB was detected at all time points in groupII and the low NF κB activity detected in group III was significantly lower than that of group II ( P <0.05). No IL 2mRNA expression was detected at any time point in group I,whereas high level expression was detected at all time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that of group II ( P <0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation immunotolerance. 展开更多
关键词 Liver specific antigen(LSA) Liver transplantation IMMUNOTOLERANCE NF κB
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